The landmark lOM report, """"""""Emerging Infections: Microbial Threats to Health in the United States"""""""" highlighted the importance of studying Infectious diseases in natural animal hosts-60% of all human pathogens are directly transmitted from or emergent from animal reservoirs. Understanding the behavior of pathogens in their natural hosts, including mechanisms of persistence, evolution of virulence, acquisition and maintenance of antimicrobial resistance, and genetic change underlying transmission phenotypes, is now widely recognized as critically important to addressing emerging infections. The broad spectrum of microbial pathogens, from small RNA viruses to multicellular parasites, which infect domestic and wild animals, provides a rich opportunity to understand pathogen behavior in their natural hosts both as models for human disease as well as for directly understanding pathogen evolution and transmission to humans. Our program specifically and uniquely addresses this need and integrates clinically trained veterinarians with post-PhD fellows to provide a rigorous and dynamic training environment. Prominent examples of T32 trainee success in the past 10 years include: i) 7 trainees transitioned to individual K08 (post-DVMs) or F32 (post-PhD) awards;ii) 10 post-DVM trainees received the PhD (4 remain in training);and iii) all past trainees continue in research and there is clear evidence of progressive career advancement. The program has two types of trainees: (i) clinically-trained veterinarians, usually with residency training in clinical microbiology, internal medicine, or pathology;and (ii) post-PhD fellows who expand and enhance their research capabilities in infectious diseases. Critically, both groups of trainees are integrated in the laboratory research training phase with shared trainee led research-in-progress seminars, shared trainee led outside speaker seminars, and in the responsible conduct of research progression. This integration significantly enhances the training environment as each type of trainee brings unique strengths. We propose to continue training 5 fellows per year (3 post-DVM;2 post-PhD) with a minimum of 3 years of dedicated laboratory research for the clinically trained fellows and at least 2 years for post-PhD fellows.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007025-33
Application #
8280381
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
1989-09-30
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
33
Fiscal Year
2012
Total Cost
$309,782
Indirect Cost
$21,947
Name
Washington State University
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164
Mosites, Emily; Aol, George; Otiang, Elkanah et al. (2016) Child height gain is associated with consumption of animal-source foods in livestock-owning households in Western Kenya. Public Health Nutr :1-10
Smith, Erin P; Miller, Cheryl N; Child, Robert et al. (2016) Postreplication Roles of the Brucella VirB Type IV Secretion System Uncovered via Conditional Expression of the VirB11 ATPase. MBio 7:
Mosites, Emily; Thumbi, Samuel M; Otiang, Elkanah et al. (2016) Relations between Household Livestock Ownership, Livestock Disease, and Young Child Growth. J Nutr 146:1118-24
Mosites, Emily M; Rabinowitz, Peter M; Thumbi, Samuel M et al. (2015) The Relationship between Livestock Ownership and Child Stunting in Three Countries in Eastern Africa Using National Survey Data. PLoS One 10:e0136686
Brown, Wendy C; Turse, Joshua E; Lawrence, Paulraj K et al. (2015) Loss of Immunization-Induced Epitope-Specific CD4 T-Cell Response following Anaplasma marginale Infection Requires Presence of the T-Cell Epitope on the Pathogen and Is Not Associated with an Increase in Lymphocytes Expressing Known Regulatory Cell Phenot Clin Vaccine Immunol 22:742-53
O'Loughlin, Jason L; Eucker, Tyson P; Chavez, Juan D et al. (2015) Analysis of the Campylobacter jejuni genome by SMRT DNA sequencing identifies restriction-modification motifs. PLoS One 10:e0118533
Ducken, Deirdre R; Brown, Wendy C; Alperin, Debra C et al. (2015) Subdominant Outer Membrane Antigens in Anaplasma marginale: Conservation, Antigenicity, and Protective Capacity Using Recombinant Protein. PLoS One 10:e0129309
O'Loughlin, Jason L; Samuelson, Derrick R; Braundmeier-Fleming, Andrea G et al. (2015) The Intestinal Microbiota Influences Campylobacter jejuni Colonization and Extraintestinal Dissemination in Mice. Appl Environ Microbiol 81:4642-50
Nydam, Seth D; Shah, Devendra H; Call, Douglas R (2014) Transcriptome analysis of Vibrio parahaemolyticus in type III secretion system 1 inducing conditions. Front Cell Infect Microbiol 4:1
Wudiri, George A; Pritchard, Suzanne M; Li, Hong et al. (2014) Molecular requirement for sterols in herpes simplex virus entry and infectivity. J Virol 88:13918-22

Showing the most recent 10 out of 85 publications