The multidisciplinary UAB Immunology Training Program, """"""""Immunologic Diseases and Basic Immunology"""""""", is focused on training highly motivated pre-doctoral students and PhD and MD graduates in the fields of translational and fundamental immunology. A major strength of the program is the broad expertise and research interests of its faculty, encompassing stem cell and lymphocyte differentiation;cellular immunology;molecular immunology;gene organization, structure and function of immunoglobulins, T cell receptors, Fc receptors, complement, and lymphokines;secretory immunity;transgenic models of immune function;immunogenetics;host responses to infectious diseases, mucosal immunology, transplantation immunology, neuroimmunology, and bioinformatics. Ten predoctoral trainees are selected from the graduate students enrolled in the interdisciplinary Cellular and Molecular Biology Program or the recently established Graduate Biomedical Sciences Program following successful completion of their first year of graduate study. Their training will last up to five years. This population includes students in the Medical Scientist Training Program. Five, now three, postdoctoral trainees with a MD, PhD or equivalent terminal degree are selected on the basis of prior academic and research performance, letters of recommendation, and personal interviews. Their training will last up to three years. In the 35 years since its inception, more than 150 trainees have participated in this training program with more than two-thirds of these individuals continuing to pursue scientific careers in academia, biotechnology, and at other research institutions. Over the last five years, 39 trainees, 16 postdoctoral and 23 pre-doctoral, have been supported by this training program. Of these, 36 (92%) are continuing in biomedical research, administration or research staff (academic staff), teaching and/or training, with 21 still pursuing PhD or post-graduate training at UAB. Our trainees have published 110 peer-reviewed manuscripts over the past five years. Eleven of the twelve pre-docs who have earned their PhDs are pursuing postgraduate training, with the remaining trainee working as a research associate outside UAB. Of the twelve post-docs who have completed their training, five (42%) have achieved faculty positions. Over the past five years, the composition of our trainees has been 41% male and 59% female;and has included 18% under- represented minorities (15% African American, 3% Native American). Because a large number of the faculty are involved in the care of patients with immunologic diseases in addition to their research programs, the program provides an interface between basic and applied immunology. Opportunities directly related to human diseases are available in autoimmune diseases, bioinformatics, vaccine development, immunodeficiencies, neoplastic diseases, immune-complex diseases, host-defense defects, dental caries, microbial pathogenesis, and transplantation immunology.

Public Health Relevance

The multidisciplinary UAB Immunology Training Program, Immunologic Diseases and Basic Immunology, is focused on training highly motivated pre-doctoral students and PhD and MD graduates in the fields of translational and fundamental immunology. Our trainees are selected for their commitment to research and academic medicine. The success of their future investigator-initiated studies, which are best represented by R01-caliber projects, requires the development of skilled creativity and the ability to identify and achieve scientific goals of significance to the biomedical research enterprise.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Transplantation Biology &Immunology-2 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Gibson, Sara A; Yang, Wei; Yan, Zhaoqi et al. (2017) Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation. J Immunol 198:4244-4254
Owusu, Benjamin Y; Zimmerman, Kurt A; Murphy-Ullrich, Joanne E (2017) The role of the endoplasmic reticulum protein calreticulin in mediating TGF-?-stimulated extracellular matrix production in fibrotic disease. J Cell Commun Signal :
Rowse, Amber L; Gibson, Sara A; Meares, Gordon P et al. (2017) Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cells. J Neurooncol 132:219-229
Hamilton, Jennie A; Wu, Qi; Yang, PingAr et al. (2017) Cutting Edge: Endogenous IFN-? Regulates Survival and Development of Transitional B Cells. J Immunol 199:2618-2623
Evonuk, Kirsten S; Prabhu, Sumanth D; Young, Martin E et al. (2017) Myocardial ischemia/reperfusion impairs neurogenesis and hippocampal-dependent learning and memory. Brain Behav Immun 61:266-273
Pham-Hua, Dana; Padgett, Lindsey E; Xue, Bing et al. (2017) Islet encapsulation with polyphenol coatings decreases pro-inflammatory chemokine synthesis and T cell trafficking. Biomaterials 128:19-32
González-Juarbe, Norberto; Shen, Haiqian; Bergman, Molly A et al. (2017) YopE specific CD8+ T cells provide protection against systemic and mucosal Yersinia pseudotuberculosis infection. PLoS One 12:e0172314
Seleme, Maria C; Kosmac, Kate; Jonjic, Stipan et al. (2017) Tumor Necrosis Factor Alpha-Induced Recruitment of Inflammatory Mononuclear Cells Leads to Inflammation and Altered Brain Development in Murine Cytomegalovirus-Infected Newborn Mice. J Virol 91:
Wang, Yuge; Hwangpo, Tracy; Martin, Maureen P et al. (2016) Killer cell immunoglobulin-like receptors are associated with common variable immune deficiency pathogenesis. J Allergy Clin Immunol 138:1495-1498
Pegues, Melissa A; McWilliams, Ian L; Szalai, Alexander J (2016) C-reactive protein exacerbates renal ischemia-reperfusion injury: are myeloid-derived suppressor cells to blame? Am J Physiol Renal Physiol 311:F176-81

Showing the most recent 10 out of 217 publications