The multidisciplinary UAB Immunology Training Program, Immunologic Diseases and Basic Immunology, is focused on training highly motivated pre-doctoral students and PhD and MD graduates in the fields of translational and fundamental immunology. A major strength of the program is the broad expertise and research interests of its faculty, encompassing stem cell and lymphocyte differentiation; cellular immunology; molecular immunology; gene organization, structure and function of immunoglobulins, T cell receptors, Fc receptors, complement, and lymphokines; secretory immunity; transgenic models of immune function; immunogenetics; host responses to infectious diseases, mucosal immunology, transplantation immunology, neuroimmunology, and bioinformatics. Ten predoctoral trainees are selected from the graduate students enrolled in the interdisciplinary Cellular and Molecular Biology Program or the recently established Graduate Biomedical Sciences Program following successful completion of their first year of graduate study. Their training will last up to five years. This population includes students in the Medical Scientist Training Program. Five, now three, postdoctoral trainees with a MD, PhD or equivalent terminal degree are selected on the basis of prior academic and research performance, letters of recommendation, and personal interviews. Their training will last up to three years. In the 35 years since its inception, more than 150 trainees have participated in this training program with more than two-thirds of these individuals continuing to pursue scientific careers in academia, biotechnology, and at other research institutions. Over the last five years, 39 trainees, 16 postdoctoral and 23 pre-doctoral, have been supported by this training program. Of these, 36 (92%) are continuing in biomedical research, administration or research staff (academic staff), teaching and/or training, with 21 still pursuing PhD or post-graduate training at UAB. Our trainees have published 110 peer-reviewed manuscripts over the past five years. Eleven of the twelve pre-docs who have earned their PhDs are pursuing postgraduate training, with the remaining trainee working as a research associate outside UAB. Of the twelve post-docs who have completed their training, five (42%) have achieved faculty positions. Over the past five years, the composition of our trainees has been 41% male and 59% female; and has included 18% under- represented minorities (15% African American, 3% Native American). Because a large number of the faculty are involved in the care of patients with immunologic diseases in addition to their research programs, the program provides an interface between basic and applied immunology. Opportunities directly related to human diseases are available in autoimmune diseases, bioinformatics, vaccine development, immunodeficiencies, neoplastic diseases, immune-complex diseases, host-defense defects, dental caries, microbial pathogenesis, and transplantation immunology.

Public Health Relevance

The multidisciplinary UAB Immunology Training Program, 'Immunologic Diseases and Basic Immunology', is focused on training highly motivated pre-doctoral students and PhD and MD graduates in the fields of translational and fundamental immunology. Our trainees are selected for their commitment to research and academic medicine. The success of their future investigator-initiated studies, which are best represented by R01-caliber projects, requires the development of skilled creativity and the ability to identify and achieve scientific goals of significance to the biomedical research enterprise.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
4T32AI007051-39
Application #
9034523
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Gondre-Lewis, Timothy A
Project Start
1976-07-01
Project End
2018-05-31
Budget Start
2016-06-01
Budget End
2017-05-31
Support Year
39
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Boppana, Sushma; Goepfert, Paul (2018) Understanding the CD8 T-cell response in natural HIV control. F1000Res 7:
Gibson, Sara A; Yang, Wei; Yan, Zhaoqi et al. (2018) CK2 Controls Th17 and Regulatory T Cell Differentiation Through Inhibition of FoxO1. J Immunol 201:383-392
Owusu, Benjamin Y; Zimmerman, Kurt A; Murphy-Ullrich, Joanne E (2018) The role of the endoplasmic reticulum protein calreticulin in mediating TGF-?-stimulated extracellular matrix production in fibrotic disease. J Cell Commun Signal 12:289-299
DiToro, Daniel; Winstead, Colleen J; Pham, Duy et al. (2018) Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. Science 361:
Yan, Zhaoqi; Gibson, Sara A; Buckley, Jessica A et al. (2018) Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases. Clin Immunol 189:4-13
Ergen, Elizabeth N; Yusuf, Nabiha (2018) Inhibition of interleukin-12 and/or interleukin-23 for the treatment of psoriasis: What is the evidence for an effect on malignancy? Exp Dermatol 27:737-747
Hamilton, Jennie A; Wu, Qi; Yang, PingAr et al. (2018) Cutting Edge: Intracellular IFN-? and Distinct Type I IFN Expression Patterns in Circulating Systemic Lupus Erythematosus B Cells. J Immunol 201:2203-2208
Pham-Hua, Dana; Padgett, Lindsey E; Xue, Bing et al. (2017) Islet encapsulation with polyphenol coatings decreases pro-inflammatory chemokine synthesis and T cell trafficking. Biomaterials 128:19-32
González-Juarbe, Norberto; Shen, Haiqian; Bergman, Molly A et al. (2017) YopE specific CD8+ T cells provide protection against systemic and mucosal Yersinia pseudotuberculosis infection. PLoS One 12:e0172314
Pham, Duy (2017) A Method to In Vitro Differentiate Th9 Cells from Mouse Naïve CD4+ T Cells. Methods Mol Biol 1585:51-57

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