Abstract

The Harvard Medical School-based research training program entitled """"""""Infectious Diseases and Basic Microbiological Mechanisms"""""""" offers a minimum of 2 years of laboratory-based research training for physicians and postdoctoral Ph.D. scientists.
The aim i s to provide substantive research training experience with relevant supporting course work and thereby to enable the postdoctoral trainee to become an independent investigator in the fields of infectious diseases and microbiology. Training laboratories are available in eight major areas (1) virology, (2) bacteriology, (3) parasitology, (4) immunology, (5) molecular biology and genetics, (6) cell biology, (7) epidemiology, and (8) biochemistry. The purpose of this renewal application is the continuation of this highly successful program, which has been supported by the NIH for the past 25 years During the past 5-year period, approximately 176 trainees completed the program. Of these individuals, 131 now hold university faculty positions or work in government service. An additional 37 have taken positions as scientists in industry. Although only eight positions per year are supported by this grant, 175 postdoctoral trainees are currently being funded by our training program in the laboratories of the 39 participating research mentors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007061-30
Application #
7272829
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Garges, Susan
Project Start
1976-07-01
Project End
2008-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
30
Fiscal Year
2007
Total Cost
$390,666
Indirect Cost

  Institution

Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Midani, Firas S; Weil, Ana A; Chowdhury, Fahima et al. (2018) Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection. J Infect Dis 218:645-653
Bourque, Daniel L; Bhuiyan, Taufiqur Rahman; Genereux, Diane P et al. (2018) Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways. Infect Immun 86:
Pacheco, Alline R; Lazarus, Jacob E; Sit, Brandon et al. (2018) CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection. MBio 9:
Bhattacharyya, Roby P; Thakku, Sri Gowtham; Hung, Deborah T (2018) Harnessing CRISPR Effectors for Infectious Disease Diagnostics. ACS Infect Dis 4:1278-1282
Brennan-Krohn, Thea; Pironti, Alejandro; Kirby, James E (2018) Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant Enterobacteriaceae. Antimicrob Agents Chemother 62:
Kamareddine, Layla; Robins, William P; Berkey, Cristin D et al. (2018) The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism. Cell Metab 28:449-462.e5
Brennan-Krohn, Thea; Yoon, Edward; Nishino, Michiya et al. (2018) Arthroconidia in lung tissue: an unusual histopathological finding in pulmonary coccidioidomycosis. Hum Pathol 71:55-59
Clark, Lars E; Mahmutovic, Selma; Raymond, Donald D et al. (2018) Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. Nat Commun 9:1884
Mou, Xiangyu; Souter, Skye; Du, Juan et al. (2018) Synthetic bottom-up approach reveals the complex interplay of Shigella effectors in regulation of epithelial cell death. Proc Natl Acad Sci U S A 115:6452-6457
Kanjilal, Sanjat; Sater, Mohamad R Abdul; Thayer, Maile et al. (2018) Trends in Antibiotic Susceptibility in Staphylococcus aureus in Boston, Massachusetts, from 2000 to 2014. J Clin Microbiol 56:

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