The Harvard Medical School-based research training program entitled "Infectious Diseases and Basic Microbiological Mechanisms" offers a minimum of two years of laboratory-based research training for physicians and postdoctoral PhD scientists.
The aim i s to provide substantive research training experience with relevant supporting course work and thereby to enable the postdoctoral trainee to become an independent investigator in the fields of infectious diseases and microbiology. Training laboratories are in nine major areas: (1) bacteriology, including pathogenesis, genetics, toxins, virulence factors, cell biology, host defense, and vaccine development;(2) virology, including pathogenesis, genetics, cell biology, virulence, host defense, antiviral agents, and retrovirology;(3) parasitology, including pathogenesis, chloroquine resistance of malaria, parasite-cell interactions, and host defense;(4) immunology, including complement, T cells, B cells, and regulation of the antibody response;(5) epidemiology, including pharmacoepidemiology and nosocomial infections;(6) cell biology of eosinophils and basophils;(7) biochemistry of proteins, carbohydrates, and lipids;(8) molecular biology and genetics;and (9) biodefense and emerging infectious diseases. The purpose of this renewal application for this T32 grant is the continuation of this highly successful program, which has been supported by the NIH for the past 30 years. During the past five-year period, approximately 248 trainees completed the program. Of these individuals, 175 now hold positions in academia or work in government service. Sixty hold the rank of assistant professor or higher at 52 colleges, universities and medical schools around the world. An additional 36 have taken positions as scientists in industry. Thirteen are identified as practicing physicians many of whom also hold academic appointments. Although only eight positions per year are supported by this grant, 191 postdoctoral trainees are currently being funded by our, training program in the laboratories of the 51 participating research mentors.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
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Harvard University
Schools of Medicine
United States
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An, Dingding; Oh, Sungwhan F; Olszak, Torsten et al. (2014) Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell 156:123-33
Shenoy, Erica S; Noubary, Farzad; Kim, Jiyeon et al. (2014) Concordance of PCR and culture from nasal swabs for detection of methicillin-resistant Staphylococcus aureus in a setting of concurrent antistaphylococcal antibiotics. J Clin Microbiol 52:1235-7
Yi, Chae-ryun; Allen, John E; Russo, Brian et al. (2014) Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins. J Biol Chem 289:30101-13
Shenoy, Erica S; Paras, Molly L; Noubary, Farzad et al. (2014) Natural history of colonization with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE): a systematic review. BMC Infect Dis 14:177
Muhammed, Maged; Anagnostou, Theodora; Desalermos, Athanasios et al. (2013) Fusarium infection: report of 26 cases and review of 97 cases from the literature. Medicine (Baltimore) 92:305-16
Mitsuma, S F; Mansour, M K; Dekker, J P et al. (2013) Promising new assays and technologies for the diagnosis and management of infectious diseases. Clin Infect Dis 56:996-1002
Mansour, Michael K; Tam, Jenny M; Khan, Nida S et al. (2013) Dectin-1 activation controls maturation of *-1,3-glucan-containing phagosomes. J Biol Chem 288:16043-54
Robins, William P; Faruque, Shah M; Mekalanos, John J (2013) Coupling mutagenesis and parallel deep sequencing to probe essential residues in a genome or gene. Proc Natl Acad Sci U S A 110:E848-57
Seshadri, Chetan; Turner, Marie T; Lewinsohn, David M et al. (2013) Lipoproteins are major targets of the polyclonal human T cell response to Mycobacterium tuberculosis. J Immunol 190:278-84
Shenoy, Erica S; Kim, Jiyeon; Rosenberg, Eric S et al. (2013) Discontinuation of contact precautions for methicillin-resistant staphylococcus aureus: a randomized controlled trial comparing passive and active screening with culture and polymerase chain reaction. Clin Infect Dis 57:176-84

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