The Harvard Medical School-based research training program entitled """"""""Infectious Diseases and Basic Microbiological Mechanisms"""""""" offers a minimum of two years of laboratory-based research training for physicians and postdoctoral PhD scientists.
The aim i s to provide substantive research training experience with relevant supporting course work and thereby to enable the postdoctoral trainee to become an independent investigator in the fields of infectious diseases and microbiology. Training laboratories are in nine major areas: (1) bacteriology, including pathogenesis, genetics, toxins, virulence factors, cell biology, host defense, and vaccine development;(2) virology, including pathogenesis, genetics, cell biology, virulence, host defense, antiviral agents, and retrovirology;(3) parasitology, including pathogenesis, chloroquine resistance of malaria, parasite-cell interactions, and host defense;(4) immunology, including complement, T cells, B cells, and regulation of the antibody response;(5) epidemiology, including pharmacoepidemiology and nosocomial infections;(6) cell biology of eosinophils and basophils;(7) biochemistry of proteins, carbohydrates, and lipids;(8) molecular biology and genetics;and (9) biodefense and emerging infectious diseases. The purpose of this renewal application for this T32 grant is the continuation of this highly successful program, which has been supported by the NIH for the past 30 years. During the past five-year period, approximately 248 trainees completed the program. Of these individuals, 175 now hold positions in academia or work in government service. Sixty hold the rank of assistant professor or higher at 52 colleges, universities and medical schools around the world. An additional 36 have taken positions as scientists in industry. Thirteen are identified as practicing physicians many of whom also hold academic appointments. Although only eight positions per year are supported by this grant, 191 postdoctoral trainees are currently being funded by our, training program in the laboratories of the 51 participating research mentors.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases B Subcommittee (MID)
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Mcsweegan, Edward
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Harvard University
Schools of Medicine
United States
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Carpenter, Stephen M; Nunes-Alves, Cláudio; Booty, Matthew G et al. (2016) A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis. PLoS Pathog 12:e1005380
Martin, Constance J; Carey, Allison F; Fortune, Sarah M (2016) A bug's life in the granuloma. Semin Immunopathol 38:213-20
Absalon, Sabrina; Robbins, Jonathan A; Dvorin, Jeffrey D (2016) An essential malaria protein defines the architecture of blood-stage and transmission-stage parasites. Nat Commun 7:11449
Gohil, Shruti K; Cao, Chenghua; Phelan, Michael et al. (2016) Impact of Policies on the Rise in Sepsis Incidence, 2000-2010. Clin Infect Dis 62:695-703
Rhee, Chanu; Kadri, Sameer; Huang, Susan S et al. (2016) Objective Sepsis Surveillance Using Electronic Clinical Data. Infect Control Hosp Epidemiol 37:163-71
Russo, Brian C; Stamm, Luisa M; Raaben, Matthijs et al. (2016) Intermediate filaments enable pathogen docking to trigger type 3 effector translocation. Nat Microbiol 1:16025
Rhee, Chanu; Kadri, Sameer S; Danner, Robert L et al. (2016) Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes. Crit Care 20:89
Rhee, Chanu; Huang, Susan S; Berríos-Torres, Sandra I et al. (2015) Surgical site infection surveillance following ambulatory surgery. Infect Control Hosp Epidemiol 36:225-8
Inci, Fatih; Filippini, Chiara; Baday, Murat et al. (2015) Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics. Proc Natl Acad Sci U S A 112:E4354-63
Rhee, Chanu; Murphy, Michael V; Li, Lingling et al. (2015) Lactate Testing in Suspected Sepsis: Trends and Predictors of Failure to Measure Levels. Crit Care Med 43:1669-76

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