In the current funding period of this long-standing training grant, four students were funded and two ol these have completed their Ph.D. In the past 10 years, 10 students have received their Ph.D. with the help oi funding from this grant. Overall, since its inception in 1971, the Immunology Graduate Program at UConn Health Center has awarded 70 Ph.D. degrees. Our graduates have obtained high quality positions in academic clinical, industrial and governmental research settings. The Training Grant Faculty is comprised of 14 members providing expertise in teaching and in highly relevant research areas of immunology, including microbia immunity, cancer immunology and immunotherapy, vaccine development, autoimmunity. mucosa immunology, immunoregulation and lymphocyte development. Furthermore, the facilities at UCIIC for application to research projects and for student training in modern techniques are state-of-the-art. Thus, our institution and our faculty can provide the breadth and depth in immunology research required to train anc produce successful scientists. As in the past, the central focus of our program will be to train students to become independent investigators and educators who will contribute importantly to expanding knowledge in the areas of basic and/or applied immunology. This goal will be achieved by formal coursework, research seminars, supervised thesis research, individualized instruction and guidance, formal presentations at journal clubs, biannual progress reports, attendance at scientific meetings and writing manuscripts. The training obtained through this tested program with the help of this training grant not only will give the student a strong foundation in modern laboratory techniques, but will help to develop his/her ability to conceive and solve experimental problems, to critically evaluate data, and to effectively communicate information verbally and in writing.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
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University of Connecticut
Schools of Medicine
United States
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Hammond, Matthew D; Taylor, Roslyn A; Mullen, Michael T et al. (2014) CCR2+ Ly6C(hi) inflammatory monocyte recruitment exacerbates acute disability following intracerebral hemorrhage. J Neurosci 34:3901-9
Bose, Tina O; Colpitts, Sara L; Pham, Quynh-Mai et al. (2014) CD11a is essential for normal development of hematopoietic intermediates. J Immunol 193:2863-72
Bose, Tina O; Pham, Quynh-Mai; Jellison, Evan R et al. (2013) CD11a regulates effector CD8 T cell differentiation and central memory development in response to infection with Listeria monocytogenes. Infect Immun 81:1140-51
St Rose, Marie-Clare; Taylor, Roslyn A; Bandyopadhyay, Suman et al. (2013) CD134/CD137 dual costimulation-elicited IFN-? maximizes effector T-cell function but limits Treg expansion. Immunol Cell Biol 91:173-83
McNamara, Jeffrey T; Schramm, Craig M; Singh, Anurag et al. (2012) Phenotypic changes to the endogenous antigen-specific CD8+ T cell response correlates with the development and resolution of allergic airway disease. Am J Pathol 180:1991-2000
Obar, Joshua J; Jellison, Evan R; Sheridan, Brian S et al. (2011) Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation. J Immunol 187:4967-78
Housley, William J; Adams, Catherine O; Nichols, Frank C et al. (2011) Natural but not inducible regulatory T cells require TNF-alpha signaling for in vivo function. J Immunol 186:6779-87
Blair, David A; Turner, Damian L; Bose, Tina O et al. (2011) Duration of antigen availability influences the expansion and memory differentiation of T cells. J Immunol 187:2310-21
Housley, William J; Adams, Catherine O; Vang, Amanda G et al. (2011) Peroxisome proliferator-activated receptor gamma is required for CD4+ T cell-mediated lymphopenia-associated autoimmunity. J Immunol 187:4161-9
McAleer, Jeremy P; Saris, Christiaan J M; Vella, Anthony T (2011) The WSX-1 pathway restrains intestinal T-cell immunity. Int Immunol 23:129-37

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