This revised renewal application seeks five years of continued funding for a training program in Basic Microbiology and Infectious Diseases (BMID) to support 7 predoctoral trainees with the aim of producing independent investigators capable of sustaining productive research programs studying molecular mechanisms of infectious disease. This program has been active for 27 years. The program comprises 16 faculty preceptors from 7 departments (Molecular Genetics &Microbiology, Biochemistry &Molecular Biology, Infectious Diseases and Pathology, Oral Biology, Pediatrics, Pathology, Immunology &Laboratory Medicine, and Medicine) within the Colleges of Medicine, Dentistry and Veterinary Medicine in the Health Science Center at the University of Florida. The program faculty include bacteriologists (Brown, Gulig, Morris, Progulske-Fox and Southwick), virology (Bloom, Berns, Byrne, Condit, Flanegan, Goodenow, Moyer, McFadden, and Muzyczka), and mycology (Lewin and Nguyen). The program faculty have expertise in genetics, cell biology, pathogenesis, immunology, epidemiology and molecular biology. The program faculty also includes clinician scientists (Berns, Byrne, Morris and Southwick), thus reinforcing the clinical relevance and application of microbiology and infectious disease. Predoctoral trainees are recruited and initially trained in collaboration with the College of Medicine's Interdisciplinary Program in biomedical Sciences (IDP). The pool of trainee candidates averages 53 per year, they come from throughout the US, and they average combined verbal and quantitative GRE scores of 1250 and GPAs of 3.5. The IDP provides comprehensive classroom training, an introductory laboratory, laboratory rotations, and advanced course work in specialized disciplines. Subsequent training focuses on independent laboratory research supplemented with program-specific activities stressing communications skills. Predoctoral training requires a total of approximately 5 years. This training program provides a strong interdisciplinary infrastructure for enhancing the training of scientists in the area of infectious disease. This will increase the number of researchers trained to study the molecular mechanisms of the pathogenesis of disease and develop therapies for diseases of humans caused by a wide range of microbial agents.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases B Subcommittee (MID)
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Mcsweegan, Edward
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University of Florida
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United States
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Moye, Zachary D; Son, Minjun; Rosa-Alberty, Ariana E et al. (2016) Effects of Carbohydrate Source on Genetic Competence in Streptococcus mutans. Appl Environ Microbiol 82:4821-34
Feldman, Emily R; Kara, Mehmet; Oko, Lauren M et al. (2016) A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency. mSphere 1:
Spear, Allyn; Ogram, Sushma A; Morasco, B Joan et al. (2015) Viral precursor protein P3 and its processed products perform discrete and essential functions in the poliovirus RNA replication complex. Virology 485:492-501
Wang, Xiaomei; Su, Jin; Sherman, Alexandra et al. (2015) Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells. Blood 125:2418-27
Jones, Melissa K; Grau, Katrina R; Costantini, Veronica et al. (2015) Human norovirus culture in B cells. Nat Protoc 10:1939-47
Messer, Harald G P; Jacobs, Derek; Dhummakupt, Adit et al. (2015) Inhibition of H3K27me3-specific histone demethylases JMJD3 and UTX blocks reactivation of herpes simplex virus 1 in trigeminal ganglion neurons. J Virol 89:3417-20
Rogers, Geoffrey L; Herzog, Roland W (2015) Gene therapy for hemophilia. Front Biosci (Landmark Ed) 20:556-603
Biswas, Moanaro; Sarkar, Debalina; Kumar, Sandeep R P et al. (2015) Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4+CD25+FoxP3+ Treg. Blood 125:2937-47
Sack, B K; Wang, X; Sherman, A et al. (2015) Immune responses to human factor IX in haemophilia B mice of different genetic backgrounds are distinct and modified by TLR4. Haemophilia 21:133-9
Rogers, Geoffrey L; Suzuki, Masataka; Zolotukhin, Irene et al. (2015) Unique Roles of TLR9- and MyD88-Dependent and -Independent Pathways in Adaptive Immune Responses to AAV-Mediated Gene Transfer. J Innate Immun 7:302-14

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