PI: GOLDBERG, DANIEL E Project: 2T32AI007172-31 Title: Infectious Diseases-Basic Microbial Pathogenic Mechanisms Accession Number: 12157149 ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM APPLICATION AND HAS NOT BEEN PROOFED BY AN SRA.WHEN THERE ARE PROBLEMS WITH THE APPLICATION SCANNING PROCESS, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE. ================== This is an application to renew the Infectious Diseases/Basic Microbial Pathogenesis Training Grant from Washington University. With the advent of generally available antibiotic therapy about 50 years ago, many physicians and scientists predicted the end of infectious diseases as a major area of health concern. Subsequent events have proven this prediction wrong, and the past decades have seen the emergence of many newly identified infectious diseases, including Lyme Disease, eriichiosis, SARS, West Nile encephalitis, avian/swine influenza and HIV, as major health problems. The reemergence of old infectious diseases, such as malaria and bacterial infections, in new more virulent and more antibiotic resistant forms also has increased public attention on the health problems posed by infectious diseases. The threat of microbial bioterrorism has also come to the forefront. It is rare that a week goes by without some troubling headline concerning new infectious disease outbreaks. Thus, far from gradual disappearance as a health concern, infectious diseases have emerged in the past decade as being of even greater importance to the health concerns of the nation than previously. The emerging antibiotic resistance of current pathogens, the discovery of new disease agents, and the specter of bioterrorism have made clear the necessity of increased fundamental scientific investigation into all aspects of infectious diseases. The purpose of the Washington University Training Program in Infectious Diseases/Basic Microbial Pathogenesis is to help fulfill this need by recruiting promising young investigators to this field and training them in outstanding research programs with preeminent investigators who collaborate across multiple disciplines (or who function in interdisciplinary teams) to perform infectious disease research. Our Training Program, which has had NIH support for the past 30 years, integrates faculty from four departments: Medicine, Pediatrics, Molecular Microbiology and Pathology &Immunology. The program provides training to M.D., Ph.D., and M.D./Ph.D. postdoctoral fellows, and to Ph.D. and M.D./Ph.D. students, in disciplines related to pathogenesis and host defense in Infectious Diseases. The laboratories of the program preceptors use tools of molecular biology, biochemistry, genetics, genomics, immunology, cell biology and translational medicine. Thus, the program trains young investigators to be able to answer the important questions of microbial pathogenesis, from studies of basic biology through application to the bedside.
Old infectious diseases are re-emerging in resistant form and new infectious diseases are being identified at an alarming rate. The goal of this grant is to train a new generation of researchers to develop new strategies to combat the infectious scourges of mankind.
|Bauckman, Kyle A; Owusu-Boaitey, Nana; Mysorekar, Indira U (2015) Selective autophagy: xenophagy. Methods 75:120-7|
|Westergard, Laura; True, Heather L (2014) Wild yeast harbour a variety of distinct amyloid structures with strong prion-inducing capabilities. Mol Microbiol 92:183-93|
|Beck, Josh R; Muralidharan, Vasant; Oksman, Anna et al. (2014) PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes. Nature 511:592-5|
|Hsiao, Ansel; Ahmed, A M Shamsir; Subramanian, Sathish et al. (2014) Members of the human gut microbiota involved in recovery from Vibrio cholerae infection. Nature 515:423-6|
|Cortez, Victor S; Fuchs, Anja; Cella, Marina et al. (2014) Cutting edge: Salivary gland NK cells develop independently of Nfil3 in steady-state. J Immunol 192:4487-91|
|Cortez, Victor S; Cervantes-Barragan, Luisa; Song, Christina et al. (2014) CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection. J Exp Med 211:623-33|
|Bobo, Linda D; El Feghaly, Rana E; Chen, Yee-Shiuan et al. (2013) MAPK-activated protein kinase 2 contributes to Clostridium difficile-associated inflammation. Infect Immun 81:713-22|
|Lazear, Helen M; Pinto, Amelia K; Ramos, Hilario J et al. (2013) Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the central nervous system. J Virol 87:11401-15|
|Schuessler, Andrea; Funk, Anneke; Lazear, Helen M et al. (2012) West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response. J Virol 86:5708-18|
|McNulty, Samantha N; Fischer, Kerstin; Mehus, Joseph O et al. (2012) Absence of Wolbachia endobacteria in Chandlerella quiscali, an avian filarial parasite. J Parasitol 98:382-7|
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