This Training Grant, now entering its 31st year, provides support for a unique interdisciplinary pre-doctoral training program in Immunology at the Johns Hopkins University School of Medicine. The Training Grant is the core source of funding for the Immunology Training Program. The mission of this interdepartmental program is to provide students with training in cellular, biochemical, and genetic approaches to the biology of the immune response. We seek to provide trainees with the ability to identify significant research questions in immunology, to find solutions to these questions, to think broadly and creatively about biological problems, and to communicate ideas effectively to others. There are 38 faculty members who participate in the program and provide a broad range of training opportunities for trainees. These areas include genetic and cellular aspects of immune development, antigen recognition, immune regulation, tolerance, structural biology of immune proteins, innate immunity, autoimmunity, immune cell signaling, cancer immunology, IgE-mediated immunologic reactions and the host response to infection. In these areas, the training environment is enhanced by institutional strength in relevant areas of basic science and/or clinical medicine. Cross-fertilization between basic research and clinical disease studies is an important aspect of the training environment. The pre-doctoral program places emphasis on rigorous training in basic biochemistry and molecular and cellular biology in addition to immunology. Progress of trainees throughout the didactic and research progress is monitored closely through multiple mechanisms. An extensive and successful program for recruiting minority students has been implemented.

Public Health Relevance

Immune-mediated mechanisms are involved in a striking variety of human diseases, both common and rare. Diseases that involve the immune system affect up to 20% of North Americans, Europeans and Japanese. The goal of the Immunology Training Program is to train the next generation of Immunologists who, through active scholarship contribute to the generation of new knowledge on the basic mechanisms of the immune system and the application of this knowledge to the understanding and treatment of disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007247-32
Application #
8711158
Study Section
Transplantation Biology &Immunology-2 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
1982-09-01
Project End
2018-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
32
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Jackson, Christopher M; Kochel, Christina M; Nirschl, Christopher J et al. (2016) Systemic Tolerance Mediated by Melanoma Brain Tumors Is Reversible by Radiotherapy and Vaccination. Clin Cancer Res 22:1161-72
Alme, Angela K B; Karir, Beerinder S; Faltas, Bishoy M et al. (2016) Blocking immune checkpoints in prostate, kidney, and urothelial cancer: An overview. Urol Oncol 34:171-81
Manivannan, Sivabalan; Baxter, Victoria K; Schultz, Kimberly L W et al. (2016) Protective Effects of Glutamine Antagonist 6-Diazo-5-Oxo-l-Norleucine in Mice with Alphavirus Encephalomyelitis. J Virol 90:9251-62
Hamblet, Corinne E; Makowski, Stefanie L; Tritapoe, Julia M et al. (2016) NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3. J Immunol 196:2614-26
Wasilewski, Lisa N; El-Diwany, Ramy; Munshaw, Supriya et al. (2016) A Hepatitis C Virus Envelope Polymorphism Confers Resistance to Neutralization by Polyclonal Sera and Broadly Neutralizing Monoclonal Antibodies. J Virol 90:3773-82
Kouo, Theodore; Huang, Lanqing; Pucsek, Alexandra B et al. (2015) Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells. Cancer Immunol Res 3:412-23
Walker-Sperling, Victoria E K; Cohen, Valerie J; Tarwater, Patrick M et al. (2015) Reactivation Kinetics of HIV-1 and Susceptibility of Reactivated Latently Infected CD4+ T Cells to HIV-1-Specific CD8+ T Cells. J Virol 89:9631-8
Schultz, Kimberly L W; Vernon, Patty S; Griffin, Diane E (2015) Differentiation of neurons restricts Arbovirus replication and increases expression of the alpha isoform of IRF-7. J Virol 89:48-60
El-Diwany, Ramy; Wasilewski, Lisa N; Witwer, Kenneth W et al. (2015) Acute Hepatitis C Virus Infection Induces Consistent Changes in Circulating MicroRNAs That Are Associated with Nonlytic Hepatocyte Release. J Virol 89:9454-64
Bruns, Heiko; Bessell, Catherine; Varela, Juan Carlos et al. (2015) CD47 Enhances In Vivo Functionality of Artificial Antigen-Presenting Cells. Clin Cancer Res 21:2075-83

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