This Is a competing continuation for our current training program in immunology that has been continuously funded since 1984. The program is a combined pre- and postdoctoral training program in immunology. Predoctoral students will receive the Ph.D. at the end of the training. Since the faculty have increased we believe that we have both the applicant pool and the training opportunity to support 5 predocs. In addition we are requesting 1 additional slot, to be funded at NC A&T. This training program is primarily based in the Department of Microbiology and Immunology and laboratories are located in the Lineberger Comprehensive Cancer Center, the Department of Dermatology, Department of Neurology, the Dental Research Center (Oral Biology Program), Genetics and Molecular Biology, the Neurosciences Center and the Department of Medicine. The training for both pre- and postdoctoral fellows will take place in those laboratories. This training program is particularly strong in the areas of immunogenetics and regulation of the immune response. The research costs of the trainees are born by the research grants of the training faculty and research performed by the trainees normally appears as a joint author with the training faculty members. Physicians, veterinarians, and Ph.D.s in other disciplines will be recruited as postdoctoral trainees. Serious effort will be made to attract physician trainees by publicity among training programs in internal medicine, and in rheumatology. Postdoctoral training will be individual and, depending on the trainee, may consist of a combination of course work as well as laboratory research. Training may occur in more than a single laboratory.

Public Health Relevance

We are requesting funds to continue training of immunologists. A unique feature of this proposal is the close partnership with NC A&T for the recruitment of minority scientists into PhD programs. This program will aid in not only development of the next generation of scientists and furthers the future diversity of science.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007273-28
Application #
8320170
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
1984-07-01
Project End
2015-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
28
Fiscal Year
2012
Total Cost
$309,262
Indirect Cost
$21,444
Name
University of North Carolina Chapel Hill
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Monteith, Andrew J; Vincent, Heather A; Kang, SunAh et al. (2018) mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a. J Immunol 201:371-382
Kroger, Charles J; Clark, Matthew; Ke, Qi et al. (2018) Therapies to Suppress ? Cell Autoimmunity in Type 1 Diabetes. Front Immunol 9:1891
Cheng, Ning; Watkins-Schulz, Rebekah; Junkins, Robert D et al. (2018) A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1-insensitive models of triple-negative breast cancer. JCI Insight 3:
Allard, Denise E; Wang, Yan; Li, Jian Joel et al. (2018) Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment. J Clin Invest 128:4727-4741
Junkins, Robert D; Gallovic, Matthew D; Johnson, Brandon M et al. (2018) A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination. J Control Release 270:1-13
Hagar, Jon A; Edin, Matthew L; Lih, Fred B et al. (2017) Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock. J Immunol 199:3634-3643
Swanson, Karen V; Junkins, Robert D; Kurkjian, Cathryn J et al. (2017) A noncanonical function of cGAMP in inflammasome priming and activation. J Exp Med 214:3611-3626
Taylor, Nicholas A; Vick, Sarah C; Iglesia, Michael D et al. (2017) Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer. J Clin Invest 127:3472-3483
Manzoor, Fatima; Johnson, Mark C; Li, Chengwen et al. (2017) ?-cell-specific IL-35 therapy suppresses ongoing autoimmune diabetes in NOD mice. Eur J Immunol 47:144-154
Clark, Matthew; Kroger, Charles J; Tisch, Roland M (2017) Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response. Front Immunol 8:1898

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