This is the fifth renewal application seeking support for our Molecular Microbial Pathogenesis Training Program (MMPTP) conducted by an interdisciplinary group of faculty at Meharry Medical College (MMC) and Vanderbilt University (VU) to provide Ph.D. training in the molecular basis of infectious diseases. The program will provide opportunities for four African-Americans and other URM committed to infectious diseases careers. Highly interactive MMC and VU mentors who conduct cutting-edge research in molecular microbial pathogenesis will participate in the training. The Program offers trainees opportunities for new discoveries and breakthroughs in the study ofthe pathogen-host interactions of microbes causing disease including biodefense agents. The innovative features of this program are grounded on cutting-edge science and molecular approaches to study the pathogenesis of microbe-host cell interactions in the following areas: (i) Microbial attachment to receptors, invasion and replication;(ii) Functional genomics and systems biology of microbial infections;(iii) Cell host signaling evoked by pathogens including toxins;(iv) Unique pathogen target genes required for survival;(v) Structural biology and function of new microbial virulent factors;and (vi) Interactions of novel immune molecules with pathogens. The PD and co-PD will be assisted by internal and external advisory committees consisting of MMC and VU training faculty and external leaders in thefield.Trainee Committees on Instruction will include MMC and VU mentors. Trainees will take the program flagship course "Cell Host Microbe Interaction", at least one didactic course at VU and participate in training there as needed. All trainees and faculty will participate in Journal Clubs, Works-In-Progress, the Seminar Series including presentations by MMPTP faculty and students, MMPTP seminars with external speakers, the "Annual Research Sjmiposium", and the annual retreat. This is a strong training program administered at an institution with an excellent record of recruiting and retaining Ph.D. minority students. The program goals are enhanced by the increased collaborative research and training programs at MMC and VU resulting from the MMC-VU alliance. The support requested will address the shortage of research in critical areas of infectious disease and of minority scientists in this discipline.
This unique training program in the molecular basis of infectious diseases offered by Meharry and Vanderbilt faculty will train talented African-Americans and other URMs in infectious diseases and will foster their career development consistent with the NIAID mission. The program will train a new generation of infectious disease minority scientists who will address the national ethic under-representation in biomedical research.
|Kinlock, Ballington L; Wang, Yudi; Turner, Tiffany M et al. (2014) Transcytosis of HIV-1 through vaginal epithelial cells is dependent on trafficking to the endocytic recycling pathway. PLoS One 9:e96760|
|Wang, Yudi; Kinlock, Ballington L; Shao, Qiujia et al. (2014) HIV-1 Vif inhibits G to A hypermutations catalyzed by virus-encapsidated APOBEC3G to maintain HIV-1 infectivity. Retrovirology 11:89|
|Hamilton, Vanae; Singha, Ujjal K; Smith, Joseph T et al. (2014) Trypanosome alternative oxidase possesses both an N-terminal and internal mitochondrial targeting signal. Eukaryot Cell 13:539-47|
|Radin, Jana N; Gonzalez-Rivera, Christian; Frick-Cheng, Arwen E et al. (2014) Role of connexin 43 in Helicobacter pylori VacA-induced cell death. Infect Immun 82:423-32|
|Duncan, Melanie R; Fullerton, Marjorie; Chaudhuri, Minu (2013) Tim50 in Trypanosoma brucei possesses a dual specificity phosphatase activity and is critical for mitochondrial protein import. J Biol Chem 288:3184-97|
|Timmons, Christine L; Shao, Qiujia; Wang, Chenliang et al. (2013) GB virus type C E2 protein inhibits human immunodeficiency virus type 1 assembly through interference with HIV-1 gag plasma membrane targeting. J Infect Dis 207:1171-80|
|Radin, Jana N; Gaddy, Jennifer A; Gonzalez-Rivera, Christian et al. (2013) Flagellar localization of a Helicobacter pylori autotransporter protein. MBio 4:e00613-12|
|Chambers, Melissa G; Pyburn, Tasia M; González-Rivera, Christian et al. (2013) Structural analysis of the oligomeric states of Helicobacter pylori VacA toxin. J Mol Biol 425:524-35|
|Hall 3rd, Mack; Misra, Smita; Chaudhuri, Minu et al. (2011) Peptide aptamer mimicking RAD51-binding domain of BRCA2 inhibits DNA damage repair and survival in Trypanosoma brucei. Microb Pathog 50:252-62|
|Rana, Tanu; Misra, Smita; Mittal, Mukul K et al. (2011) Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania. J Biol Chem 286:6614-26|
Showing the most recent 10 out of 25 publications