The program will provide pre- and post doctoral trainees with a solid academic background in cellular and molecular immunology, including relevant coursework, regularly scheduled seminars and journal clubs, and rigorous laboratory training with the goal of preparing our students for careers in immunology research. The 24 Immunology Training Program (ITP) faculty represent a broad range of departmental affiliations and research interests but most have either primary or secondary appointments in the Departments of Microbiology, Pathology, and/or Medicine. Predoctoral students will be jointly admitted to one of these departments where they will follow a modified curriculum specifically designed for students in the ITP. However, the major focus for both pre- and postdoctoral students will be an innovative, challenging and focused research experience. This will be accomplished by coupling research training in the laboratory of one of the training faculty with supportive advisory input from other ITP members. The diverse research interests of our faculty provide trainees with a wide range of opportunities in both basic and translational research. Particular areas of faculty expertise include regulation of B cell development and function, transcriptional regulation of gene activity, mechanisms of lymphocyte transformation, immune responses to microbial infections, factors predisposing to autoimmune disease, cytokine biology, cell activation and apoptosis, immunotherapy and vaccine development, toll-like receptors, and innate immunity. We intend to support 8 predoctoral and 3 postdoctoral students each year. Trainees will be selected based on their academic record and previous evidence of commitment and talent for basic research. Special efforts will be made to recruit minority and MD/PhD candidates. The major goals of the program will be: (1) to recruit students of the highest quality, including underrepresented minorities;(2) to provide these trainees with a multidisciplinary background in the immunological sciences, coupled with intensive laboratory training in a particular research topic;(3) to teach the trainees how to ask relevant and feasible research questions;(4) to instill these trainees with a sense of ethical behavior;(5) to develop effective written and oral communication skills among the trainees, and (6) to facilitate collaborative interactions among both students and faculty of the ITP.

Public Health Relevance

The immune response is critical for defense against pathogens and malignancies but an overexuberant response can lead to a range of autoimmune diseases. This program is intended to train the next generation of basic and translational investigators to develop novel treatments for immunologically based diseases and new strategies for vaccine development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007309-24
Application #
8319626
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
1988-09-15
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
24
Fiscal Year
2012
Total Cost
$371,804
Indirect Cost
$21,426
Name
Boston University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Kijewski, Suzanne D G; Akiyama, Hisashi; Feizpour, Amin et al. (2016) Access of HIV-2 to CD169-dependent dendritic cell-mediated trans infection pathway is attenuated. Virology 497:328-36
Nazari, Banafsheh; Rice, Lisa M; Stifano, Giuseppina et al. (2016) Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90. Am J Pathol 186:2650-64
Ip, Blanche; Cilfone, Nicholas A; Belkina, Anna C et al. (2016) Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production. Obesity (Silver Spring) 24:102-12
Christmann, Romy B; Wooten, Alicia; Sampaio-Barros, Percival et al. (2016) miR-155 in the progression of lung fibrosis in systemic sclerosis. Arthritis Res Ther 18:155
Mathes, Allison L; Rice, Lisa; Affandi, Alsya J et al. (2015) CpGB DNA activates dermal macrophages and specifically recruits inflammatory monocytes into the skin. Exp Dermatol 24:133-9
Chiswick, Evan L; Mella, Juan R; Bernardo, John et al. (2015) Acute-Phase Deaths from Murine Polymicrobial Sepsis Are Characterized by Innate Immune Suppression Rather Than Exhaustion. J Immunol 195:3793-802
Duffau, Pierre; Menn-Josephy, Hanni; Cuda, Carla M et al. (2015) Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model. Arthritis Rheumatol 67:3146-57
Watkins, Amanda A; Yasuda, Kei; Wilson, Gabriella E et al. (2015) IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis. J Immunol 194:1467-79
Hilliard, Kristie L; Allen, Eri; Traber, Katrina E et al. (2015) The Lung-Liver Axis: A Requirement for Maximal Innate Immunity and Hepatoprotection during Pneumonia. Am J Respir Cell Mol Biol 53:378-90
Ip, Blanche C; Hogan, Andrew E; Nikolajczyk, Barbara S (2015) Lymphocyte roles in metabolic dysfunction: of men and mice. Trends Endocrinol Metab 26:91-100

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