This proposal requests support for renewal of the long-standing pre-and postdoctoral Training in Virology T32 at the University of Pennsylvania. Over the past 20 years hundreds of PhD and postdoctoral trainees have been mentored in viral research by our faculty. This training program currently includes 21 laboratories directed by well- established and well-funded investigators at the University of Pennsylvania, the Wistar Institute, and CHOP selected from over 40 NIH-funded laboratories studying viruses on the contiguous campus that houses these institutions. Addition of new trainers including George Shaw, Matt Weitzman, Sara Cherry, Kyong-Mi Chang and Carolina Lopez has strengthened an already outstanding cadre of mentors. The primary goal of the Virology Program is to identify, mentor and develop the careers of future leaders dedicated to biomedical research in the field of virology. Toward this end, we crafted a well-organized training program that includes outstanding mentors, an exceptional pool of candidates, outstanding institutional support and facilities, and training activities comprised of formal coursework in virology and immunology, an invited scientist speaker series, a student and postdoc research in progress seminar series, and a career development/Alumni day. New initiatives include Individualized Development Plans for all trainees, a UPenn Virology LinkedIn group to track and network with former trainees, a well described set of metrics to gauge success, and fellowship preparation instruction for incoming PhD students. Penn continues to provide direct and tangible institutional commitment to training in the biomedical sciences by supporting predoctoral trainees for their first 21 months of graduate school and funding the Biomedical Postdoctoral Programs office. Over the past five year funding period, this Virology T32 directly supported a total of 27 trainees including 19 predoctoral trainees (12 PhD, 6 MD/PhD, 1 VMD/PhD, 9 men, 10 women, 1 under-represented minority) and eight postdoctoral fellows (2 men, 6 women, 1 under-represented minority). These 27 trainees worked in the labs of 15 different trainers. Success of this program is exemplified by the former trainees who developed into independent scientists studying viral biology including Carolyn Coyne, Blossom Damnia, Anthony Nicola, Andy Pekosz, and Matt Weitzman among others. In following the review recommendations, we propose supporting four pre-doctoral and three postdoctoral trainees per year.

Public Health Relevance

The enclosed revised application is for renewal for a long-standing Training Program in Virology based at the University of Pennsylvania. This Training Program will support the development of four predoctoral and three PhD postdoctoral trainees per year in one of 21 laboratories directed by well-established principle investigators. The training experience will enable a talented group of trainees to further our understanding of and address the increasing public health problem of viral diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI007324-21A1
Application #
8550945
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
1989-07-01
Project End
2018-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
21
Fiscal Year
2013
Total Cost
$296,934
Indirect Cost
$14,808
Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Han, Ziying; Bart, Stephen M; Ruthel, Gordon et al. (2016) Ebola virus mediated infectivity is restricted in canine and feline cells. Vet Microbiol 182:102-7
Birdwell, L Dillon; Zalinger, Zachary B; Li, Yize et al. (2016) Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon. J Virol 90:3160-72
Molleston, Jerome M; Sabin, Leah R; Moy, Ryan H et al. (2016) A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation. Genes Dev 30:1658-70
Bradley, William P; Boyer, Mark A; Nguyen, Hieu T et al. (2016) Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages. Infect Immun 84:998-1015
Ocwieja, Karen E; Sherrill-Mix, Scott; Liu, Changchun et al. (2015) A reverse transcription loop-mediated isothermal amplification assay optimized to detect multiple HIV subtypes. PLoS One 10:e0117852
Vande Burgt, Nathan H; Kaletsky, Rachel L; Bates, Paul (2015) Requirements within the Ebola Viral Glycoprotein for Tetherin Antagonism. Viruses 7:5587-602
Zalinger, Zachary B; Elliott, Ruth; Rose, Kristine M et al. (2015) MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus. J Virol 89:12330-40
Drake, Mary Jane; Bates, Paul (2015) Application of gene-editing technologies to HIV-1. Curr Opin HIV AIDS 10:123-7
Mitchell, Angela M; Stone, Amy E L; Cheng, Linling et al. (2015) Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver. MBio 6:e02510
Stoddard, Mark B; Li, Hui; Wang, Shuyi et al. (2015) Identification, molecular cloning, and analysis of full-length hepatitis C virus transmitted/founder genotypes 1, 3, and 4. MBio 6:e02518

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