The UCSF Immunology Training Program encompasses 46 laboratories engaged in molecular, cellular, and in vivo immunology and actively training ~250 graduate and postdoctoral scientists. Areas of active research include many areas of contemporary immunology such as lymphocyte cell surface receptor function and mechanisms of signaling;mechanisms of innate immune recognition;lymphocyte and leukocyte cell biology, adhesion and migration;cytokine expression and in vivo function;CD4 T cell effector and regulatory function;cytotoxic T cell and NK cell function;microRNA regulation of immune cell function, lymphocyte development, hematopoiesis and their relationship to leukemia and lymphoma;in vivo mechanisms of autoimmunity, allergy, and inflammatory diseases;human immunodeficiency;and immune defense against infectious agents including malaria, Histoplasma, Tuberculosis, and HIV. Over the past 29 years, a vital graduate training program leading to the Ph.D. has been developed by the immunology program faculty and has been supported by this training grant for the past 25 years. This program is designed to provide a solid background in genetics, cell biology, molecular biology, and mammalian tissue and organ biology as well as thorough training in modern immunology. The interdisciplinary nature of this training is enhanced by the affiliation of the Immunology Program with the UCSF Biomedical Sciences Program (BMS), an interdisciplinary program that also includes the study of infectious agents and inflammatory processes as well as other aspects of mammalian tissue/organ development, function, and disease. In addition to formal coursework and thesis research, the Immunology Program includes an active weekly seminar series of outside immunology speakers, both Immunology and BMS student-faculty journal clubs, an annual Immunology Program Retreat (held jointly with UC Berkeley immunologists), and seminar courses on advanced immunological topics. These activities provide an excellent training environment for postdoctoral fellows as well as for graduate students. Postdoctoral training is additionally enhanced by a postdoc research-in-progress seminar series and a recently developed postdoctoral mentoring program.
Immunology is the study of the immune system, the major natural purpose of which is to defend us against infections. Additionally, it has been found that the immune system protects us from cancer, but when dysregulated causes tissue damage in autoimmune, allergic, and inflammatory diseases, and contributes importantly to the tissue damage and loss of function in a number of chronic diseases including atherosclerosis (heart disease and stroke), type 2 diabetes, and probably several degenerative neurological diseases such as Alzheimer's disease. This training program trains the next generation of scientists to study the immune system and develop new therapeutic approaches for its modulation as needed to ameliorate disease.
|Lam, Viola C; Lanier, Lewis L (2017) NK cells in host responses to viral infections. Curr Opin Immunol 44:43-51|
|Laidlaw, Brian J; Schmidt, Timothy H; Green, Jesse A et al. (2017) The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells. J Exp Med 214:639-649|
|Hsu, Lih-Yun; Cheng, Debra A; Chen, Yiling et al. (2017) Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. J Exp Med 214:833-849|
|Huizar, John; Tan, Corey; Noviski, Mark et al. (2017) Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells. Immunohorizons 1:188-197|
|Trang, Karen; Raposo, Rui André; Lowe, Margaret M et al. (2017) Relative mRNA Expression Levels of Restriction Factors and Antiviral Genes in Fetal and Adult Human Monocytes and Monocyte-Derived Macrophages. Viral Immunol 30:142-148|
|Fontana, Mary F; de Melo, Gabrielly L; Anidi, Chioma et al. (2017) Correction: Macrophage Colony Stimulating Factor Derived from CD4+ T Cells Contributes to Control of a Blood-Borne Infection. PLoS Pathog 13:e1006192|
|Anderton, Brittany; Camarda, Roman; Balakrishnan, Sanjeev et al. (2017) MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer. EMBO Rep 18:569-585|
|Bronevetsky, Yelena; Burt, Trevor D; McCune, Joseph M (2016) Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-? Signaling. J Immunol 197:4344-4350|
|Ali, Ibraheem; Conrad, Ryan J; Ott, Melanie (2016) Retrovirus Integration: Some Assembly Required? Cell Host Microbe 20:702-704|
|Van Dyken, Steven J; Nussbaum, Jesse C; Lee, Jinwoo et al. (2016) A tissue checkpoint regulates type 2 immunity. Nat Immunol 17:1381-1387|
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