The purpose of our NIH-sponsored training program in immunology and virology, which has just completed its 23rd year, is to recruit talented, well-trained, and well-motivated graduate students and give them first rate preparation for competitive careers in academic research and industry. This training program is sponsored by the University of Massachusetts Medical School's (UMMS) Interdepartmental Immunology and Microbiology Program (IMP) Committee. This group fosters immunology and virology research and training at UMMS and offers a PhD specialization in Immunology and Microbiology as part of a larger school-wide graduate program overseen by the Graduate School of Biomedical Sciences (GSBS). The training faculty is a subset of the IMP faculty and consists of 24 preceptors representing 6 UMMS Departments. As of 8/1/13 there were 49 predoctoral students committed to or enrolled in the IMP. We previously have been funded for 4 predoctoral and one postdoctoral fellow and are now seeking stipends for 5 predoctoral fellows, as we discontinue our Training Grant-sponsored postdoctoral training program. Research training in the IMP is an interdisciplinary, cooperative undertaking, which depends upon and has contributed to regular interaction among students and faculty from different clinical and basic science departments. It is characterized by a structured curriculum, by intense faculty involvement, and by a formalized emphasis on developing skills in hypothesis-driven research, in sophisticated molecular screening approaches, and in research communication. Strengths of this program include combining sophisticated molecular and cellular immunology approaches and intense collaborative research in the areas of 1. viral (including influenza and HIV) immunology, biodefense, and vaccine design;2. toll receptor signaling and innate immunity;3. transplantation and development of humanized mouse models;and 4. gene therapy, with an eye toward translating this basic research into the clinic. This NIH supported Immunology Training Grant has been an integral part of our program for the past 23 years, and we are requesting another 5 years of support.

Public Health Relevance

This is an application to recruit talented, well-trained, and well-motivated graduate students and give them first rate preparation for competitive careers in academic research and industry in the areas of immunology and virology.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Allergy & Clinical Immunology-1 (AITC)
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Prograis, Lawrence J
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University of Massachusetts Medical School Worcester
Schools of Medicine
United States
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Rittershaus, Emily S C; Baek, Seung-Hun; Krieger, Inna V et al. (2018) A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis. Cell Chem Biol 25:1495-1505.e3
Devarajan, Priyadharshini; Jones, Michael C; Kugler-Umana, Olivia et al. (2018) Pathogen Recognition by CD4 Effectors Drives Key Effector and Most Memory Cell Generation Against Respiratory Virus. Front Immunol 9:596
Marshall, Nikki B; Vong, Allen M; Devarajan, Priyadharshini et al. (2017) NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection. J Immunol 198:1142-1155
Mishra, Bibhuti B; Lovewell, Rustin R; Olive, Andrew J et al. (2017) Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol 2:17072
Watkin, Levi B; Mishra, Rabinarayan; Gil, Anna et al. (2017) Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion. J Allergy Clin Immunol 140:1206-1210
Che, Jenny W; Daniels, Keith A; Selin, Liisa K et al. (2017) Heterologous Immunity and Persistent Murine Cytomegalovirus Infection. J Virol 91:
Aslan, Nuray; Watkin, Levi B; Gil, Anna et al. (2017) Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires. MBio 8:
Devarajan, Priyadharshini; Bautista, Bianca; Vong, Allen M et al. (2016) New Insights into the Generation of CD4 Memory May Shape Future Vaccine Strategies for Influenza. Front Immunol 7:136
Smith, Clare M; Proulx, Megan K; Olive, Andrew J et al. (2016) Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype. MBio 7:
Conley, James M; Gallagher, Michael P; Berg, Leslie J (2016) T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells. Front Immunol 7:76

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