. The Molecular Mechanisms of Viral Pathogenesis Training Program at The Scripps Research Institute has provided advanced training for Postdoctoral Fellows in areas relevant for the study of viral pathogenesis for the past 25 years. The Program has functioned under the expectation that training of the next generation of scientists will require mentoring in a broad-base of relevant, cutting edge disciplines and technologies; this training will allow the Trainees to become independent and outstanding scientists, which will be needed to address the crucial scientific and medical questions of the 21 century. To accomplish our goal, the 18 Training Faculty have a broad range of scientific research expertise and members hail from the departments of Chemistry, Chemical Physiology, Integrative Structural and Computational Biology, Immunology and Microbial Science, Molecular and Experimental Medicine, and Molecular Therapeutics, all united under a common philosophy: to provide strong mentor-based training to Postdoctoral Fellows in a scientifically dynamic, highly collaborative, and interactive scientific environment. A T32-supported and initiated individual development plan (IDP) will guide and enrich the training experience. Moreover, it is a primary goal of the Training Program to best equip the Trainees to undertake responsible, unbiased, and innovative basic and/or clinical research, be it in an academic, biotechnology, or in a pharmaceutical industry setting. Trainees also receive training in the ethics of research, grant writing, scientific communication and the ethical and proper use of animals, and human stem cells, cells, and tissues in research. All Training Faculty have a distinguished record of training Postdoctoral Fellows, and have active research programs in virology, viral pathogenesis, structural biology, immunology, chemical biology, molecular genetics, or viral-mediated oncogenesis. Seven new Mentors have been added to replace the departing Training Faculty. Training is supported for a minimum of 2 years, with encouragement to obtain alternative support after year 2.

Public Health Relevance

Training of the next generation of scientists is needed to address the crucial scientific and medical questions of the 21 century. The Molecular Mechanisms of Viral Pathogenesis Training Program at the Scripps Research Institute has for 24 years mentored young scientists to undertake responsible, unbiased, and innovative basic and/or clinical research, be it in an academic, biotechnology, or in an industrial setting. We are asking for 5 years of funding to continue our training program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007354-28
Application #
9526393
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
1989-09-30
Project End
2021-08-31
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
28
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Kessing, Cari F; Spudich, Serena; Valcour, Victor et al. (2017) High Number of Activated CD8+ T Cells Targeting HIV Antigens Are Present in Cerebrospinal Fluid in Acute HIV Infection. J Acquir Immune Defic Syndr 75:108-117
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Kessing, Cari F; Nixon, Christopher C; Li, Chuan et al. (2017) In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a ""Block-and-Lock"" Strategy for HIV-1 Treatment. Cell Rep 21:600-611
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Marro, Brett S; Ware, Brian C; Zak, Jaroslav et al. (2017) Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-? signaling. Proc Natl Acad Sci U S A 114:3708-3713
Takata, Hiroshi; Buranapraditkun, Supranee; Kessing, Cari et al. (2017) Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection. Sci Transl Med 9:
Moyer, Crystal L; Besser, Eli S; Nemerow, Glen R (2016) A Single Maturation Cleavage Site in Adenovirus Impacts Cell Entry and Capsid Assembly. J Virol 90:521-32
Kirchdoerfer, Robert N; Abelson, Dafna M; Li, Sheng et al. (2015) Assembly of the Ebola Virus Nucleoprotein from a Chaperoned VP35 Complex. Cell Rep 12:140-149
Routh, Andrew; Chang, Max W; Okulicz, Jason F et al. (2015) CoVaMa: Co-Variation Mapper for disequilibrium analysis of mutant loci in viral populations using next-generation sequence data. Methods 91:40-47

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