This ongoing training program prepares graduate students and postdoctoral fellows for biostatistical and epidemiological research directed against the HIV epidemic. The program emphasizes strong training in statistical methodology, epidemiology, and related biologic areas. Students majoring in Biostatistics minor in Epidemiology and vice versa. Strong courses are also available in related fields such as virology, biology, health policy, population sciences, or behavioral science. The overall objective of the training program is to combine strong methodologic training with an extensive practical exposure to relevant problems and an introduction to specialized research on problems important to combating the HIV epidemic. The presence of expertise in virology, microbiology, and health care issues at the School adds to the unique environment for this training program. The Biostatistics and Epidemiology faculties are extensively involved in methodologic and collaborative research in HIV-related problems. Members of the Biostatistics Department form the Statistical Center for the AIDS Clinical Trials Group within the Center for Biostatistics in AIDS Research, and are closely involved with the Harvard School of Public Health AIDS Initiative. Members of the Departments of Epidemiology and Biostatistics are jointly involved in epidemiological studies in Botswana, Tanzania, and Thailand as well as the national AIDS research program. This provides the trainees with a very rich environment to pursue their research. Further, the department houses the McGoldrick fellows program where a small number of researchers from sub-Saharan countries (Uganda, Kenya, Botswana, Malawi and South Africa, initially) spend a term in the department being introduced to modern research methods in biostatistics and epidemiology as applied to HIV/AIDS. Interaction with these McGoldrick fellows provides students on this Training Grant a more global perspective. To facilitate student participation in these research activities, the Department of Biostatistics sponsors faculty- wide "working groups" which meet biweekly to discuss ongoing research. During the 2013-2014 academic year, there are separate working groups in adaptive trials, big data, causal inference, computational biology, brain health, environmental statistics, HIV, neurostatistics, quantitative genomics, and quantitative issues in cancer research.
The impact of the HIV/AIDS pandemic has been devastating for almost half a century ago, especially in the developing world. Wonderful advances have been made in treating the disease, but there is still much work that needs to be done in controlling, preventing and treating the disease. This grant is requesting funds to train biostatisticians and epidemiologists to continue to contribute in a coordinated fight against this virus on all fronts, from prevention and education to treatment.
|Hund, Lauren; Pagano, Marcello (2014) Extending cluster lot quality assurance sampling designs for surveillance programs. Stat Med 33:2746-57|
|Stephens, Alisa; Tchetgen Tchetgen, Eric; De Gruttola, Victor (2014) Locally efficient estimation of marginal treatment effects when outcomes are correlated: is the prize worth the chase? Int J Biostat 10:59-75|
|Anderson, Jeffrey P; Tchetgen Tchetgen, Eric J; Lo Re 3rd, Vincent et al. (2014) Antiretroviral therapy reduces the rate of hepatic decompensation among HIV- and hepatitis C virus-coinfected veterans. Clin Infect Dis 58:719-27|
|Sudfeld, Christopher R; Isanaka, Sheila; Mugusi, Ferdinand M et al. (2013) Weight change at 1 mo of antiretroviral therapy and its association with subsequent mortality, morbidity, and CD4 T cell reconstitution in a Tanzanian HIV-infected adult cohort. Am J Clin Nutr 97:1278-87|
|Izu, Alane; Cohen, Ted; Degruttola, Victor (2013) Bayesian estimation of mixture models with prespecified elements to compare drug resistance in treatment-naive and experienced tuberculosis cases. PLoS Comput Biol 9:e1002973|
|Sudfeld, Christopher R; Giovannucci, Edward L; Isanaka, Sheila et al. (2013) Vitamin D status and incidence of pulmonary tuberculosis, opportunistic infections, and wasting among HIV-infected Tanzanian adults initiating antiretroviral therapy. J Infect Dis 207:378-85|
|Sudfeld, Christopher R; Hewett, Paul C; Abuelezam, Nadia N et al. (2013) Herpes simplex virus type 2 cross-sectional seroprevalence and the estimated rate of neonatal infections among a cohort of rural Malawian female adolescents. Sex Transm Infect 89:561-7|
|Sudfeld, Christopher R; Isanaka, Sheila; Aboud, Said et al. (2013) Association of serum albumin concentration with mortality, morbidity, CD4 T-cell reconstitution among tanzanians initiating antiretroviral therapy. J Infect Dis 207:1370-8|
|Sudfeld, Christopher R; Duggan, Christopher; Histed, Alex et al. (2013) Effect of multivitamin supplementation on measles vaccine response among HIV-exposed uninfected Tanzanian infants. Clin Vaccine Immunol 20:1123-32|
|Manjourides, Justin; Lin, Hsien-Ho; Shin, Sonya et al. (2012) Identifying multidrug resistant tuberculosis transmission hotspots using routinely collected data. Tuberculosis (Edinb) 92:273-9|
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