The sustained global impact of the HIV pandemic and the challenges to the management and prevention of HIV disease will require a new generation of talented researchers. Since 1990 we have had an AIDS post-doctoral training program at UCSD designed to generate young investigators capable of conducting independent and productive research in an important area of HIV biology, pathogenesis or translational research. This proposal represents an attempt to renew this training program by a faculty of 14 who all have active, productive research programs in this area and who also have an extensive history of collaborative interactions. This faculty is committed to identifying an even mix of talented and committed M.D. and Ph.D. trainees and to provide the environment and opportunities that will result in young independent investigators in the areas of medically relevant basic research and scientifically oriented clinical research. The UCSD AIDS training grant has had remarkable success in generating new productive investigators in HIV research over the years. We have strengthened this already successful program by adding outstanding new faculty and by substantially improving our success in recruiting underrepresented minorities enhanced our long-standing success in training women investigators.

Public Health Relevance

(provided by the applicant): The long-term need of addressing the numerous unsolved challenges posed by HIV will require a next generation of talented young investigators. The UCSD AIDS training grant has had remarkable success in training productive investigators in HIV research over the years. We have strengthened the design and oversight of the program to improve further the past successes in recruitment of women and underrepresented minorities with the objective of training our excellent candidates to become the next generation of productive investigators who will address the continuing challenges of the HIV epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007384-24
Application #
8672194
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Sharma, Opendra K
Project Start
1990-08-01
Project End
2016-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
24
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Pathology
Type
Schools of Medicine
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Gianella, Sara; Chaillon, Antoine; Mutlu, Ece A et al. (2017) Effect of cytomegalovirus and Epstein-Barr virus replication on intestinal mucosal gene expression and microbiome composition of HIV-infected and uninfected individuals. AIDS 31:2059-2067
Polonskaya, Zinaida; Deng, Shenglou; Sarkar, Anita et al. (2017) T cells control the generation of nanomolar-affinity anti-glycan antibodies. J Clin Invest 127:1491-1504
Graves, Susannah K; Little, Susan J; Hoenigl, Martin (2017) Risk profile and HIV testing outcomes of women undergoing community-based testing in San Diego 2008-2014. Sci Rep 7:42183
Morris, Sheldon R; Zhao, Mitchell; Smith, Davey M et al. (2017) Longitudinal Viral Dynamics in Semen During Early HIV Infection. Clin Infect Dis 64:428-434
Oliveira, Michelli F; Chaillon, Antoine; Nakazawa, Masato et al. (2017) Early Antiretroviral Therapy Is Associated with Lower HIV DNA Molecular Diversity and Lower Inflammation in Cerebrospinal Fluid but Does Not Prevent the Establishment of Compartmentalized HIV DNA Populations. PLoS Pathog 13:e1006112
da Silva Antunes, Ricardo; Paul, Sinu; Sidney, John et al. (2017) Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses. PLoS One 12:e0169086
Vitomirov, Andrej; Ramirez-Gaona, Miguel; Mehta, Sanjay R et al. (2017) Random shearing as an alternative to digestion for mitochondrial DNA processing in droplet digital PCR. Mitochondrion 32:16-18
Chaillon, Antoine; Nakazawa, Masato; Wertheim, Joel O et al. (2017) No Substantial Evidence for Sexual Transmission of Minority HIV Drug Resistance Mutations in Men Who Have Sex with Men. J Virol 91:
Akrami, Kevan; Coletta, Joelle; Mehta, Sanjay et al. (2017) Gordonia sternal wound infection treated with ceftaroline: case report and literature review. JMM Case Rep 4:e005113
Gianella, Sara; Taylor, Jeff; Brown, Timothy R et al. (2017) Can research at the end of life be a useful tool to advance HIV cure? AIDS 31:1-4

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