This proposal requests funding to continue a program for predoctoral training and initiate a program for postdoctoral training in the immunology and pathogenesis of infectious diseases. The training program is centered in the Department of Microbiology and Immunology of the Wake Forest University School of Medicine. This proposal seeks funding for 4 predoctoral positions and 2 postdoctoral positions per year for 5 years. The goal of the training program is to prepare trainees for careers in research and teaching. Training of predoctoral students consists of a program of coursework and research leading to a Ph.D. in Microbiology and Immunology. Postdoctoral training consists of a program of research, seminars, journal clubs, teaching, and a tutorial covering bioethics, career planning, scientific and grant writing, and public presentation training. The training faculty consists of ten Departmental faculty and two faculty members who hold cross-appointments in the Department. The faculty includes established investigators in the fields of immunology, bacteriology, virology, and viral and bacterial pathogenesis. Attractive features of the training program include: 1) experienced faculty with a high level of extramural funding and a strong commitment to collaborative research;2) extensive faculty participation in the training of each student;and 3) An intensive recruiting strategy that has been highly successful in the recruitment of under-represented minority students and has maintained the overall high quality of matriculating students. The success of the training program is evidenced by the very strong publication record of the trainees and the very high quality of their subsequent postdoctoral positions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007401-19
Application #
7787040
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
1991-09-01
Project End
2012-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
19
Fiscal Year
2010
Total Cost
$172,686
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
McKay, Jerome T; Haro, Marcela A; Daly, Christina A et al. (2017) PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism. J Immunol 199:2020-2029
Keyes, Jeremiah D; Parsonage, Derek; Yammani, Rama D et al. (2017) Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals. Free Radic Biol Med 112:534-543
Ferguson, Daniel; Zhang, Jun; Davis, Matthew A et al. (2017) The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis. J Lipid Res 58:420-432
Wren, John T; Blevins, Lance K; Pang, Bing et al. (2017) Pneumococcal Neuraminidase A (NanA) Promotes Biofilm Formation and Synergizes with Influenza A Virus in Nasal Colonization and Middle Ear Infection. Infect Immun 85:
Holbrook, Beth C; D'Agostino Jr, Ralph B; Parks, Griffith D et al. (2016) Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model. Vaccine 34:4712-4717
Holbrook, Beth C; Kim, Jong R; Blevins, Lance K et al. (2016) A Novel R848-Conjugated Inactivated Influenza Virus Vaccine Is Efficacious and Safe in a Neonate Nonhuman Primate Model. J Immunol 197:555-64
McKay, Jerome T; Egan, Ryan P; Yammani, Rama D et al. (2015) PD-1 suppresses protective immunity to Streptococcus pneumoniae through a B cell-intrinsic mechanism. J Immunol 194:2289-99
Turner, Roberta L; Groitl, Peter; Dobner, Thomas et al. (2015) Adenovirus replaces mitotic checkpoint controls. J Virol 89:5083-96
Holbrook, Beth C; Hayward, Sarah L; Blevins, Lance K et al. (2015) Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection. Virology 476:124-33
Murrah, Kyle A; Turner, Roberta L; Pang, Bing et al. (2015) Replication of type 5 adenovirus promotes middle ear infection by Streptococcus pneumoniae in the chinchilla model of otitis media. Pathog Dis 73:1-8

Showing the most recent 10 out of 70 publications