This renewal application requests funds to continue a Program for graduate training in Immunology and Pathogenesis. Four predoctoral positions are requested. The majority of the faculty members in the Training Program are centered in the Department of Microbiology and Immunology, but this has been expanded to include training opportunities in areas of Immunology and Pathogenesis that are integral to lipid sciences and inflammation, cancer biology, biochemistry, genomics and aging. The goal of the training program is to prepare trainees for productive careers in academia, industry, or other science-related careers. This long standing T32 Program in Immunology and Pathogenesis has clear strengths that enhance predoctoral training, including: 1) innovative mechanisms such as the Trainee Career Development Workshops which enhance and add value to graduate training above that which is normally found in a graduate program, 2) a diverse training faculty which draws from a number of research programs throughout the Institution, 3) a flexible mechanism to expand the pool of available Training Faculty and outstanding Trainees, in order to respond to new collaborative training opportunities, 4) a history of success and new initiatives in the recruitment of URM students. The success of the Training Program is evidenced by the very strong publication record and very high quality of their subsequent postdoctoral and career positions.

Public Health Relevance

This renewal application requests funds to continue a predoctoral Program for graduate training in Immunology and Pathogenesis. The goal of this long standing Program is provide value added training to prepare students for productive careers in academia, industry, or other science-related careers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI007401-21
Application #
8337559
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
1991-09-01
Project End
2017-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
21
Fiscal Year
2012
Total Cost
$155,806
Indirect Cost
$8,929
Name
Wake Forest University Health Sciences
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Murrah, Kyle A; Turner, Roberta L; Pang, Bing et al. (2015) Replication of type 5 adenovirus promotes middle ear infection by Streptococcus pneumoniae in the chinchilla model of otitis media. Pathog Dis 73:8-Jan
Rosch, Jason W; Iverson, Amy R; Humann, Jessica et al. (2014) A live-attenuated pneumococcal vaccine elicits CD4+ T-cell dependent class switching and provides serotype independent protection against acute otitis media. EMBO Mol Med 6:141-54
Perez, Antonia C; Pang, Bing; King, Lauren B et al. (2014) Residence of Streptococcus pneumoniae and Moraxella catarrhalis within polymicrobial biofilm promotes antibiotic resistance and bacterial persistence in vivo. Pathog Dis 70:280-8
Blevins, Lance K; Wren, John T; Holbrook, Beth C et al. (2014) Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8? T cell response. J Immunol 193:5076-87
Turner, Roberta L; Wilkinson, John C; Ornelles, David A (2014) E1B and E4 oncoproteins of adenovirus antagonize the effect of apoptosis inducing factor. Virology 456-457:205-19
Crump, Katie E; Langston, P Kent; Rajkarnikar, Sujana et al. (2013) Antioxidant treatment regulates the humoral immune response during acute viral infection. J Virol 87:2577-86
Conover, Matt S; Redfern, Crystal J; Ganguly, Tridib et al. (2012) BpsR modulates Bordetella biofilm formation by negatively regulating the expression of the Bps polysaccharide. J Bacteriol 194:233-42
Juneau, Richard A; Pang, Bing; Weimer, Kristin E D et al. (2011) Nontypeable Haemophilus influenzae initiates formation of neutrophil extracellular traps. Infect Immun 79:431-8
Armbruster, Chelsie E; Pang, Bing; Murrah, Kyle et al. (2011) RbsB (NTHI_0632) mediates quorum signal uptake in nontypeable Haemophilus influenzae strain 86-028NP. Mol Microbiol 82:836-50
Conover, Matt S; Mishra, Meenu; Deora, Rajendar (2011) Extracellular DNA is essential for maintaining Bordetella biofilm integrity on abiotic surfaces and in the upper respiratory tract of mice. PLoS One 6:e16861

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