This renewal application requests funds to continue a Program for graduate training in Immunology and Pathogenesis. Four predoctoral positions are requested. The majority of the faculty members in the Training Program are centered in the Department of Microbiology and Immunology, but this has been expanded to include training opportunities in areas of Immunology and Pathogenesis that are integral to lipid sciences and inflammation, cancer biology, biochemistry, genomics and aging. The goal of the training program is to prepare trainees for productive careers in academia, industry, or other science-related careers. This long standing T32 Program in Immunology and Pathogenesis has clear strengths that enhance predoctoral training, including: 1) innovative mechanisms such as the Trainee Career Development Workshops which enhance and add value to graduate training above that which is normally found in a graduate program, 2) a diverse training faculty which draws from a number of research programs throughout the Institution, 3) a flexible mechanism to expand the pool of available Training Faculty and outstanding Trainees, in order to respond to new collaborative training opportunities, 4) a history of success and new initiatives in the recruitment of URM students. The success of the Training Program is evidenced by the very strong publication record and very high quality of their subsequent postdoctoral and career positions.

Public Health Relevance

This renewal application requests funds to continue a predoctoral Program for graduate training in Immunology and Pathogenesis. The goal of this long standing Program is provide value added training to prepare students for productive careers in academia, industry, or other science-related careers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI007401-21
Application #
8337559
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
1991-09-01
Project End
2017-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
21
Fiscal Year
2012
Total Cost
$155,806
Indirect Cost
$8,929
Name
Wake Forest University Health Sciences
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
McKay, Jerome T; Haro, Marcela A; Daly, Christina A et al. (2017) PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism. J Immunol 199:2020-2029
Grayson, Kristina M; Blevins, Lance K; Oliver, Melissa B et al. (2017) Activation-dependent modulation of Streptococcus pneumoniae-mediated death in human lymphocytes. Pathog Dis 75:
Ferguson, Daniel; Zhang, Jun; Davis, Matthew A et al. (2017) The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis. J Lipid Res 58:420-432
Goldman, Jason D; Gallaher, Amelia; Jain, Rupali et al. (2017) Infusion-Compatible Antibiotic Formulations for Rapid Administration to Improve Outcomes in Cancer Outpatients With Severe Sepsis and Septic Shock: The Sepsis STAT Pack. J Natl Compr Canc Netw 15:457-464
Wren, John T; Blevins, Lance K; Pang, Bing et al. (2017) Pneumococcal Neuraminidase A (NanA) Promotes Biofilm Formation and Synergizes with Influenza A Virus in Nasal Colonization and Middle Ear Infection. Infect Immun 85:
Keyes, Jeremiah D; Parsonage, Derek; Yammani, Rama D et al. (2017) Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals. Free Radic Biol Med 112:534-543
Holbrook, Beth C; D'Agostino Jr, Ralph B; Parks, Griffith D et al. (2016) Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model. Vaccine 34:4712-4717
Holbrook, Beth C; Kim, Jong R; Blevins, Lance K et al. (2016) A Novel R848-Conjugated Inactivated Influenza Virus Vaccine Is Efficacious and Safe in a Neonate Nonhuman Primate Model. J Immunol 197:555-64
McKay, Jerome T; Egan, Ryan P; Yammani, Rama D et al. (2015) PD-1 suppresses protective immunity to Streptococcus pneumoniae through a B cell-intrinsic mechanism. J Immunol 194:2289-99
Turner, Roberta L; Groitl, Peter; Dobner, Thomas et al. (2015) Adenovirus replaces mitotic checkpoint controls. J Virol 89:5083-96

Showing the most recent 10 out of 72 publications