This renewal application requests funds to continue a Program for graduate training in Immunology and Pathogenesis. Four predoctoral positions are requested. The majority of the faculty members in the Training Program are centered in the Department of Microbiology and Immunology, but this has been expanded to include training opportunities in areas of Immunology and Pathogenesis that are integral to lipid sciences and inflammation, cancer biology, biochemistry, genomics and aging. The goal of the training program is to prepare trainees for productive careers in academia, industry, or other science-related careers. This long standing T32 Program in Immunology and Pathogenesis has clear strengths that enhance predoctoral training, including: 1) innovative mechanisms such as the Trainee Career Development Workshops which enhance and add value to graduate training above that which is normally found in a graduate program, 2) a diverse training faculty which draws from a number of research programs throughout the Institution, 3) a flexible mechanism to expand the pool of available Training Faculty and outstanding Trainees, in order to respond to new collaborative training opportunities, 4) a history of success and new initiatives in the recruitment of URM students. The success of the Training Program is evidenced by the very strong publication record and very high quality of their subsequent postdoctoral and career positions.

Public Health Relevance

This renewal application requests funds to continue a predoctoral Program for graduate training in Immunology and Pathogenesis. The goal of this long standing Program is provide value added training to prepare students for productive careers in academia, industry, or other science-related careers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007401-22
Application #
8476190
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
1991-09-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
22
Fiscal Year
2013
Total Cost
$156,042
Indirect Cost
$8,714
Name
Wake Forest University Health Sciences
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Holbrook, Beth C; Kim, Jong R; Blevins, Lance K et al. (2016) A Novel R848-Conjugated Inactivated Influenza Virus Vaccine Is Efficacious and Safe in a Neonate Nonhuman Primate Model. J Immunol 197:555-64
Holbrook, Beth C; D'Agostino Jr, Ralph B; Parks, Griffith D et al. (2016) Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model. Vaccine 34:4712-7
Kim, Jong R; Holbrook, Beth C; Hayward, Sarah L et al. (2015) Inclusion of Flagellin during Vaccination against Influenza Enhances Recall Responses in Nonhuman Primate Neonates. J Virol 89:7291-303
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McKay, Jerome T; Egan, Ryan P; Yammani, Rama D et al. (2015) PD-1 suppresses protective immunity to Streptococcus pneumoniae through a B cell-intrinsic mechanism. J Immunol 194:2289-99
Holbrook, Beth C; Hayward, Sarah L; Blevins, Lance K et al. (2015) Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection. Virology 476:124-33
Wren, John T; Blevins, Lance K; Pang, Bing et al. (2014) Influenza A virus alters pneumococcal nasal colonization and middle ear infection independently of phase variation. Infect Immun 82:4802-12

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