This application is for renewal of a grant for funds to support 5 pre-doctoral and 4 post-doctoral trainees in the Immunology Training Program in Denver. Training is performed at three institutions, at the University of Colorado at Denver (UCD) and its associated Barbara Davis Center for Childhood Diabetes, and at National Jewish Health (NJH). All the faculty on this application are primary or secondary members of the Integrated Department of Immunology which, as its name suggests, is shared between UCD and NJH. The interests of the 28 faculty on this application represent modern immunological research ranging from lymphocyte and myeloid cell development and function to studies on infectious disease and autoimmunity in humans. Indeed, in response to changes in the nature of immunological research and the desires of incoming trainees, several physician scientists have been added to the list of trainers in this renewal application. This grant is headed by Dr. Philippa Marrack, a well known expert in T cell biology who has a long career in training pre- and post-doctoral fellows. She will be helped by Dr. Raul Torres, the Director of the Ph.D. training Program in the Immunology Department and a Steering Committee. Trainees will be chosen from pre- and post-doctoral fellows in the laboratories of any of the faculty on the program. Predoctoral fellows will be appointed after their first year in the program, when they have chosen and begun work in their training laboratories. Both pre- and post-doctoral trainees will be selected, by the Steering Committee, for appointment to the grant based on the merit of their work and their record. Trainees will be required to take a formal course in the Ethics and Conduct of Science and to attend and present in weekly "Research in Progress" sessions. Attendance at journal clubs, weekly seminars given by invited speakers from around the world and scientific symposia will be encouraged. Trainee advisory committees will meet with the trainees at least twice per year to provide guidance on research and career direction. This program has a long and distinguished record, with almost all its predoctoral trainees continuing to excellent postdoctoral work and most of its pre- and post-doctoral trainees continuing, once they finish their postdoctoral work, with careers in science. The program has seen increasing recruiting of underrepresented minorities trainees over the years and has been, and continues to be, a major focus for immunological research in the Rocky Mountain region in particular and the USA in general.

Public Health Relevance

Immunity is crucial to human and animal health. Its contribution can be increased with the use of vaccines to prevent infection and treat cancer and immunosuppressants to reduce autoimmunity. Trainees supported by this grant will become the future scientists who will work towards increased understanding of the immune system and better ways to treat human patients.)

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Colorado Denver
Schools of Medicine
United States
Zip Code
Hu, Jiancheng; Oda, Shannon K; Shotts, Kristin et al. (2014) Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response. J Immunol 193:85-95
Teodorovic, Lenka S; Babolin, Chiara; Rowland, Sarah L et al. (2014) Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies. Proc Natl Acad Sci U S A 111:E2797-806
Kirchenbaum, Greg A; St Clair, James B; Detanico, Thiago et al. (2014) Functionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM. Eur J Immunol 44:970-82
Gottlieb, Peter A; Delong, Thomas; Baker, Rocky L et al. (2014) Chromogranin A is a T cell antigen in human type 1 diabetes. J Autoimmun 50:38-41
Baker, Rocky L; Delong, Thomas; Barbour, Gene et al. (2013) Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice. J Immunol 191:3990-4
Friend, Samantha F; Peterson, Lisa K; Kedl, Ross M et al. (2013) SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells. Immunol Res 55:116-24
Pujanauski, Lindsey M; Janoff, Edward N; McCarter, Martin D et al. (2013) Mouse marginal zone B cells harbor specificities similar to human broadly neutralizing HIV antibodies. Proc Natl Acad Sci U S A 110:1422-7
Young, Mary H; U'Ren, Lance; Huang, Shouxiong et al. (2013) MAIT cell recognition of MR1 on bacterially infected and uninfected cells. PLoS One 8:e53789
Wang, Meiqin; Ramirez, Julita; Han, Junyan et al. (2013) The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis. J Allergy Clin Immunol 132:1174-1183.e8
Knowles, Heather; Li, Yuan; Perraud, Anne-Laure (2013) The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation. Immunol Res 55:241-8

Showing the most recent 10 out of 53 publications