In the past decade, dramatic advances in the understanding of HIV and its therapy have transformed HIV into a chronic, treatable disease. These advances, however, raise critical and complex questions linking basic research, clinical epidemiology, clinical trials, and outcomes research. The goal of the Harvard Program for AIDS Clinical Research Training (PACRT), which has successfully trained clinical investigators for 14 years, is to provide br6ad training in quantitative research methodologies and a closely supervised """"""""'research experience to infectious disease and other physicians at an early stage in their careers, as well as to pre-doctoral PhD students whose focus is on HIV clinical research. This training will prepare both groups to conduct clinical research of the highest quality and of direct relevance to the prevention and treatment of HIV infection, and it will prepare them for the next phase of development as independent investigators. The post-doctoral candidates will receive two years of research training under the close supervision of one or more of the 15 program faculty members. Program faculty include internationally recognized investigators in the fields of clinical virology, epidemiology, clinical trials, decision-analysis, cost-effectiveness analysis, outcomes research, and medical anthropology. Both pre-doctoral and post-doctoral trainees will receive didactic training through coursework at Harvard School of Public Health or other Harvard University sites. Primary performance sites for the post-doctoral fellows will be the Massachusetts General Hospital, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, and Harvard Medical School. In its first 14 years, this program has helped develop and launch a new cadre of independent investigators studying a broad array of clinical research issues in HIV. It's trainees have published over 100 peer reviewed manuscripts, and the success of its fellows in obtaining continued NIH support places it among the top programs in the country. The proposed continuation will allow the PACRT to help train the next generation of highly successful investigators to address the complex and evolving issues arising today in HIV clinical research.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
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Rosario, Joana A
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Harvard University
Public Health & Prev Medicine
Schools of Public Health
United States
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Dugdale, Caitlin; Brown, Sarah; Davila, Carine et al. (2017) Out of Sight: Culture-Negative Endocarditis and Endophthalmitis. Am J Med 130:e51-e53
Velásquez, Gustavo E; Calderon, Roger I; Mitnick, Carole D et al. (2017) Erratum for Velásquez et al., Pyrazinamide Resistance Assays and Two-Month Sputum Culture Status in Patients with Multidrug-Resistant Tuberculosis. Antimicrob Agents Chemother 61:
Campbell, Jeffrey I; Aturinda, Isaac; Mwesigwa, Evans et al. (2017) The Technology Acceptance Model for Resource-Limited Settings (TAM-RLS): A Novel Framework for Mobile Health Interventions Targeted to Low-Literacy End-Users in Resource-Limited Settings. AIDS Behav 21:3129-3140
McCormick, Alethea W; Abuelezam, Nadia N; Fussell, Thomas et al. (2017) Displacement of sexual partnerships in trials of sexual behavior interventions: A model-based assessment of consequences. Epidemics 20:94-101
Ramirez-Avila, Lynn; Regan, Susan; Cloete, Christie et al. (2017) Adolescent Linkage to Care After a Large-scale Transfer From a Hospital-based HIV Clinic to the Public Sector in South Africa. Pediatr Infect Dis J 36:311-313
Bebell, Lisa M; Ayebare, Arnold; Boum 2nd, Yap et al. (2017) Prevalence and correlates of MRSA and MSSA nasal carriage at a Ugandan regional referral hospital. J Antimicrob Chemother 72:888-892
Rough, Kathryn; Sun, Jenny W; Seage 3rd, George R et al. (2017) Zidovudine use in pregnancy and congenital malformations. AIDS 31:1733-1743
Escudero, Daniel J; Lurie, Mark N; Mayer, Kenneth H et al. (2017) The risk of HIV transmission at each step of the HIV care continuum among people who inject drugs: a modeling study. BMC Public Health 17:614
Zanoni, Brian C; Sibaya, Thobekile; Cairns, Chelline et al. (2017) Higher retention and viral suppression with adolescent-focused HIV clinic in South Africa. PLoS One 12:e0190260
Mundkur, Mallika L; Rough, Kathryn; Huybrechts, Krista F et al. (2017) Patterns of opioid initiation at first visits for pain in United States primary care settings. Pharmacoepidemiol Drug Saf :

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