Over the past 30 years, dramatic advances in the understanding of HIV infection and its therapy have transformed HIV into a highly treatable, chronic disease. With this evolution, critical questions have arisen about how basic research and clinical trials relate to clinical epidemiology and outcomes research, both in the U.S. and internationally. The goal of the Program for AIDS Clinical Research Training (PACRT), which has successfully trained leading HIV clinical investigators for the past 20 years, is to provide training in quantitative research methodologies with a focus on HIV clinical research to predoctoral PhD students and physicians at formative stages in their careers. This training has prepared both groups: to conduct clinical research of the highest quality and of direct relevance to the prevention and treatment of HIV infection. They will make important contributions to the scientific literature and successfully develop as independent investigators. In the next grant cycle, the PACRT candidates will receive two years of research training under the close supervision and mentorship of one or more of the 14 experienced program faculty members. Trainees will receive didactic training at Harvard School of Public Health or other Harvard University sites. Primary performance sites for the five post-doctoral fellows will be the Massachusetts General Hospital, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Children's Hospital Boston and Harvard Medical School. The primary site for the two predoctoral fellows will be the Harvard School of Public Health. This program has three specific aims for its trainees: 1) To acquire a sufficient body of knowledge of quantitative methods to conduct independent research in: clinical epidemiology, clinical trials, cost-effectiveness analysis, outcomes research, and/or implementation science. 2) To foster the creation of important scientific contributions with the close and longitudinal mentorship of program faculty. 3) To develop a primary research focus and a broad understanding of the various aspects of HIV disease for novel interdisciplinary research. Relevance: PACRT has a clearly defined and unique direction among HIV T32 programs, with its focus on clinical outcomes research, and how that research interfaces with translational research, clinical trials, and health policy. This program will play a crucial role in training the next generation of highly successful investigators to address the complex issues arising today in HIV clinical research.

Public Health Relevance

The Program for AIDS Clinical Research Training (PACRT) continues to develop and launch a new cadre of independent scientists studying a broad array of clinical and public health issues in HIV disease using the tools of clinical epidemiology, outcomes research, and cost-effectiveness analysis. These young investigators focus time, energy and training on critical and evolving questions at the forefront of HIV clinical management throughout the world.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007433-24
Application #
8851501
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Lawrence, Diane M
Project Start
1992-09-30
Project End
2016-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
24
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Harvard University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
Marx, Florian M; Yaesoubi, Reza; Menzies, Nicolas A et al. (2018) Tuberculosis control interventions targeted to previously treated people in a high-incidence setting: a modelling study. Lancet Glob Health 6:e426-e435
Shapiro, Adrienne E; Hong, Ting; Govere, Sabina et al. (2018) C-reactive protein as a screening test for HIV-associated pulmonary tuberculosis prior to antiretroviral therapy in South Africa. AIDS 32:1811-1820
Ngonzi, Joseph; Bebell, Lisa M; Bazira, Joel et al. (2018) Risk Factors for Vaginal Colonization and Relationship between Bacterial Vaginal Colonization and In-Hospital Outcomes in Women with Obstructed Labor in a Ugandan Regional Referral Hospital. Int J Microbiol 2018:6579139
Drain, Paul K; Parker, Robert A; Robine, Marion et al. (2018) Global migration of clinical research during the era of trial registration. PLoS One 13:e0192413
Cudahy, Patrick G T; Andrews, Jason R; Bilinski, Alyssa et al. (2018) Spatially targeted screening to reduce tuberculosis transmission in high-incidence settings. Lancet Infect Dis :
Murray, Eleanor J; Caniglia, Ellen C; Swanson, Sonja A et al. (2018) Patients and investigators prefer measures of absolute risk in subgroups for pragmatic randomized trials. J Clin Epidemiol 103:10-21
Rough, Kathryn; Huybrechts, Krista F; Hernandez-Diaz, Sonia et al. (2018) Using prescription claims to detect aberrant behaviors with opioids: comparison and validation of 5 algorithms. Pharmacoepidemiol Drug Saf :
Mohareb, Amir M; Ivers, Louise C (2018) Disease and Famine as Weapons of War in Yemen. N Engl J Med :
Ngonzi, Joseph; Bebell, Lisa M; Fajardo, Yarine et al. (2018) Incidence of postpartum infection, outcomes and associated risk factors at Mbarara regional referral hospital in Uganda. BMC Pregnancy Childbirth 18:270
Kaida, Angela; Dietrich, Janan J; Laher, Fatima et al. (2018) A high burden of asymptomatic genital tract infections undermines the syndromic management approach among adolescents and young adults in South Africa: implications for HIV prevention efforts. BMC Infect Dis 18:499

Showing the most recent 10 out of 198 publications