This competitive renewal proposal for an AIDS Clinical Training Grant from the Division of Geographic Medicine and Infectious Diseases (GMID) at the Tufts-New England Medical Center is submitted as an interactive program with the Brown University School of Medicine/ Miriam Hospital HIV program. Our goal is to continue to train investigators in methods of HIV/AIDS clinical research with an emphasis on the unique strengths of the two programs individually. These include: nutritional and metabolic issues in HIV, cardiovascular risk in HIV, special populations in HIV including women, ethnic minorities, injection drug users, and incarcerated populations, outcomes research and decision analysis, international AIDS research, and clinical studies in HIV/AIDS. By teaching core methods together with mentored clinical research designed and carried out by trainees under the supervision of experienced and able mentors, we expect to train the next generation of AIDS clinical investigators to a level competitive for independent funding, so that their work and the work of the training grant will have a direct impact on and improve clinical practice and outcomes in HIV infected patients. We have requested 4 funded positions per year;each trainee has the option of electing a degree program in public health or in clinical research as well as conducting a mentored research project. Didactic training for trainees, whether they select a degree program, will emphasize basic methodology in study design. The faculty for this training grant is exceptionally well funded and many of the faculty have ongoing, productive collaborations in the form of a Center for AIDS Research (CFAR), a Fogarty International AIDS Training Program (AITRP) and a Center for Drug Abuse and AIDS Research (CDAAR). Through the mentoring system, the Executive Committee of the Grant, which included faculty from both institutions, and each trainee's Research Coordination Committee, again including faculty from both institutions, we intend to individualize and optimize training opportunities for each trainee. An extensive evaluation process, including written reports and presentation of research results to the whole faculty of the training grant will ensure that each trainee is fully supported in his/her career development and that they take full advantage of the depth and breadth of the training opportunities offered.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007438-20
Application #
8320940
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Sharma, Opendra K
Project Start
1992-09-30
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
20
Fiscal Year
2012
Total Cost
$249,851
Indirect Cost
$19,162
Name
Tufts University
Department
Type
DUNS #
079532263
City
Boston
State
MA
Country
United States
Zip Code
02111
Wurcel, Alysse G; Anderson, Jordan E; Chui, Kenneth K H et al. (2016) Increasing Infectious Endocarditis Admissions Among Young People Who Inject Drugs. Open Forum Infect Dis 3:ofw157
Varghese, George M; Janardhanan, Jeshina; Mahajan, Sanjay K et al. (2015) Molecular epidemiology and genetic diversity of Orientia tsutsugamushi from patients with scrub typhus in 3 regions of India. Emerg Infect Dis 21:64-9
Dinh, Duy M; Volpe, Gretchen E; Duffalo, Chad et al. (2015) Intestinal microbiota, microbial translocation, and systemic inflammation in chronic HIV infection. J Infect Dis 211:19-27
Hong, Steven Y; Jonas, Anna; DeKlerk, Michael et al. (2015) Population-based surveillance of HIV drug resistance emerging on treatment and associated factors at sentinel antiretroviral therapy sites in Namibia. J Acquir Immune Defic Syndr 68:463-71
Wurcel, Alysse G; Merchant, Elisabeth A; Clark, Roger P et al. (2015) Emerging and Underrecognized Complications of Illicit Drug Use. Clin Infect Dis 61:1840-9
Krsak, Martin; Kent, David M; Terrin, Norma et al. (2015) Myocardial Infarction, Stroke, and Mortality in cART-Treated HIV Patients on Statins. AIDS Patient Care STDS 29:307-13
Volpe, Gretchen E; Ward, Honorine; Mwamburi, Mkaya et al. (2014) Associations of cocaine use and HIV infection with the intestinal microbiota, microbial translocation, and inflammation. J Stud Alcohol Drugs 75:347-57
Hong, Steven Y; Epstein, Lauren H; Lawrence, Kenneth et al. (2013) Evaluation of programmatic changes to an antimicrobial stewardship program with house officer feedback. J Eval Clin Pract 19:388-92
Rybak, Natasha; Koster, Michael; Gilbert, Elizabeth B et al. (2013) Building international collaborations from the ground up: Brown University partnerships in Haiti and Ukraine. R I Med J (2013) 96:33-7
Lacourse, Sylvia; Rybak, Natasha; Lewis, Carol et al. (2013) Health screening of newly resettled refugees in a primary care setting. R I Med J (2013) 96:28-32

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