The goal of this research training program in molecular virology is to produce highly qualified scientists committed to careers in biomedical research related to the molecular biology of human viral infections. The biological sciences have undergone remarkable changes made possible by the advances in molecular technologies. The era of molecular medicine has arrived. The young scientists being trained now must be well-versed in molecular and cellular biology concepts and technologies to contribute meaningful research in the future. Our proposed training program provides trainees with thorough foundations in fundamental virology and molecular biology concepts and techniques, primarily through coursework and laboratory research experience. Program enhancement is provided through trainee participation in the Molecular Virology Lecture Series, journal clubs, and attendance and presentation at national meetings, plus the wealth of seminars available throughout the Texas Medical Center. Funds are requested to establish a new training program in Molecular Virology. Support is requested for 4 predoctoral and 2 postdoctoral trainee positions. Trainees are selected competitively on the basis of past performance (academic record, test scores, laboratory experience) and on evidence of motivation and enthusiasm for research (recommendations, interviews). Seven participating faculty are from the Division of Molecular Virology and are complemented by four additional participating virologist faculty who are rostered in other Baylor College of Medicine departments; Biochemistry (2), Human and Molecular Genetics (1), and Microbiology (1). The proposed program is rigorous; its success is documented by the productivity of present trainees and the success of previous trainees in various scientific settings. The training program will be based in the Division of Molecular Virology at Baylor College of Medicine. The division has newly renovated and equipped laboratory and support space, has recently expanded its faculty by five, and is currently recruiting additional faculty. The College has recently completed an endowment campaign for support of research development and has re-organized the Graduate School so that it provides new support for departments and programs. The Texas Medical Center, location of Baylor College of Medicine, contains 40 member institutions engaged in health-related activities. Research is facilitated by a general willingness for cooperation among faculty, within Baylor and throughout the Medical Center. This dynamic setting is ideal for state-of-the-art research training in molecular virology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007471-04
Application #
2886221
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Quackenbush, Robert L
Project Start
1996-04-01
Project End
2001-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Stanton, Jeffrey J; Nofs, Sally A; Zachariah, Arun et al. (2014) Detection of elephant endotheliotropic herpesvirus infection among healthy Asian elephants (Elephas maximus) in South India. J Wildl Dis 50:279-87
Miller, Amber D; Blutt, Sarah E; Conner, Margaret E (2014) FoxP3+ regulatory T cells are not important for rotavirus clearance or the early antibody response to rotavirus. Microbes Infect 16:67-72
Gaines, David N; Operario, Darwin J; Stroup, Suzanne et al. (2014) Ehrlichia and spotted fever group Rickettsiae surveillance in Amblyomma americanum in Virginia through use of a novel six-plex real-time PCR assay. Vector Borne Zoonotic Dis 14:307-16
Nofs, Sally A; Atmar, Robert L; Keitel, Wendy A et al. (2013) Prenatal passive transfer of maternal immunity in Asian elephants (Elephas maximus). Vet Immunol Immunopathol 153:308-11
Stanton, Jeffrey J; Zong, Jian-Chao; Eng, Crystal et al. (2013) Kinetics of viral loads and genotypic analysis of elephant endotheliotropic herpesvirus-1 infection in captive Asian elephants (Elephas maximus). J Zoo Wildl Med 44:42-54
Reineke, Lucas C; Lloyd, Richard E (2013) Diversion of stress granules and P-bodies during viral infection. Virology 436:255-67
Gingaras, Cosmina; Danielson, Bryan P; Vigil, Karen J et al. (2012) Absence of XMRV in peripheral blood mononuclear cells of ARV-treatment naive HIV-1 infected and HIV-1/HCV coinfected individuals and blood donors. PLoS One 7:e31398
Reineke, Lucas C; Dougherty, Jon D; Pierre, Philippe et al. (2012) Large G3BP-induced granules trigger eIF2? phosphorylation. Mol Biol Cell 23:3499-510
Chiang, Karen; Rice, Andrew P (2012) MicroRNA-mediated restriction of HIV-1 in resting CD4+ T cells and monocytes. Viruses 4:1390-409
Blutt, S E; Miller, A D; Salmon, S L et al. (2012) IgA is important for clearance and critical for protection from rotavirus infection. Mucosal Immunol 5:712-9

Showing the most recent 10 out of 52 publications