Understanding the immune system and how it can be manipulated has formed the basis of new technologies, diagnostic tools, and safer, more effective therapies for many medical conditions. Thus, it is very important to train a new generation of young scientists to understand and harness the power of immunity. This is a competitive renewal application for years 16-21 of a training program supporting students pursuing doctoral studies in basic and translational immunology at The University of Iowa. A diversity of areas of immunology available to students is a strength of the program. The goal of the Interdisciplinary Graduate Program in Immunology is to develop the capabilities of students to become successful independent investigators in a variety of careers in basic and applied immunology. The major focus of training is intensive laboratory research conducted under the guidance and mentorship of outstanding faculty immunologists. Complementary aspects include coursework that stresses hypothesis generation and critical analysis skills, a rigorous research-oriented comprehensive examination, training in ethical issues facing scientists, teaching experience, and ample opportunities to gain proficiency in scientific writing and speaking. Students are selected without regard for any characteristics other than their potential as scientists, and are drawn from pools of applicants seeking the Ph.D. in Immunology, the M.D./Ph.D. combined degree, and initially undecided students who select an area of focus at the end of the first year of graduate study. Thirty-two Program faculty are divided into 4 categories. Experienced Mentor/Mentor faculty are active, productive researchers who have successfully trained Ph.D. students (EM) or have trained fellows, but not yet graduate students (M). New Mentors (NM) are junior faculty with appropriate training, and Resource Faculty (R) do not serve as dissertation advisors, but are valuable to the training program in teaching and committee service. How each of these categories of faculty contribute to the program and participate in graduate training is described in detail in the proposal. Information included documents faculty qualifications, student progress, administrative structure of the program, and the detailed training plan for our students. We continue to revise and optimize our Program to best meet the needs of student scientific careers and the diverse scientific workforce of the future. This grant is critical to support our continuing efforts in training predoctoral students from diverse backgrounds for independent careers as immunologists, and also to providing geographic diversity in graduate training in immunology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007485-20
Application #
8663818
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Program Officer
Prograis, Lawrence J
Project Start
1995-08-01
Project End
2015-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
20
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Iowa
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Itani, Farah R; Sinha, Sushmita; Brate, Ashley A et al. (2017) Suppression of autoimmune demyelinating disease by preferential stimulation of CNS-specific CD8 T cells using Listeria-encoded neuroantigen. Sci Rep 7:1519
Nada, Mohanad H; Wang, Hong; Workalemahu, Grefachew et al. (2017) Enhancing adoptive cancer immunotherapy with V?2V?2 T cells through pulse zoledronate stimulation. J Immunother Cancer 5:9
Gullicksrud, Jodi A; Li, Fengyin; Xing, Shaojun et al. (2017) Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection. J Immunol 199:911-919
Vacaflores, Aldo; Freedman, Samantha N; Chapman, Nicole M et al. (2017) Pretreatment of activated human CD8 T cells with IL-12 leads to enhanced TCR-induced signaling and cytokine production. Mol Immunol 81:1-15
Bangalore-Prakash, Pradeep; Stunz, Laura L; Mambetsariev, Nurbek et al. (2017) The oncogenic membrane protein LMP1 sequesters TRAF3 in B-cell lymphoma cells to produce functional TRAF3 deficiency. Blood Adv 1:2712-2723
Vijay, Rahul; Fehr, Anthony R; Janowski, Ann M et al. (2017) Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling. Proc Natl Acad Sci U S A 114:E5444-E5453
Janowski, Ann M; Colegio, Oscar R; Hornick, Emma E et al. (2016) NLRC4 suppresses melanoma tumor progression independently of inflammasome activation. J Clin Invest 126:3917-3928
Vacaflores, Aldo; Chapman, Nicole M; Harty, John T et al. (2016) Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism. PLoS One 11:e0157175
Mambetsariev, Nurbek; Lin, Wai W; Wallis, Alicia M et al. (2016) TRAF3 deficiency promotes metabolic reprogramming in B cells. Sci Rep 6:35349
Kim, Marie T; Kurup, Samarchith P; Starbeck-Miller, Gabriel R et al. (2016) Manipulating Memory CD8 T Cell Numbers by Timed Enhancement of IL-2 Signals. J Immunol 197:1754-61

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