The genomic revolution originated in the study of infectious agents, and it is destined to alter the way we diagnose, manage and prevent infectious diseases. This proposal presents a plan to train M.D., M.D./Ph.D. and Ph.D. scholars as researchers in the pathogenesis, immunology, therapeutics and prevention of infectious diseases through the use of genomics. We propose to prepare all trainees-irrespective of whether they intend to conduct their research at the bench or from the bedside, in fundamentals of both genomics and applied clinical investigation, with the goal of enhancing the translation of scientific discoveries into clinical practice. Ph.D. candidates who have completed their thesis work and M.D. candidates who have completed their clinical training will be evaluated by the Program's Steering Committee and offered admission on the basis of exceptional academic record, faculty interviews, and interest in, and aptitude for research. Every effort will be made to attract minority candidates. The training program will be interdisciplinary, involving faculty from Infectious Diseases, Biochemistry, Bioengineering, Chemical Engineering, Gastroenterology, Genetics, Health Research and Policy, Medical Informatics, Microbiology &Immunology, Pathology, and Pediatrics. All fellows will train for at least two years. Each trainee will be encouraged to take courses in clinical research and in basic sciences related to genomics. Additionally, each trainee will complete a two-year interdisciplinary core curriculum in applied genomics of infectious diseases. Beginning in the first year, each fellow will embark on an in-depth research project supervised by one or more of the Program's faculty;in many cases, joint-mentoring will involve faculty from different disciplines. In this way, many research projects will be cross-disciplinary. Quarterly seminars by trainees and an annual research retreat will be held to promote interactions between program participants. Four postdoctoral fellows are to be supported by the Program. While support from the Training grant will be for one year, a minimum of two years of support is guaranteed for each trainee using funds from the faculty mentor;all fellows will be encouraged to seek independent support after the first year. The program intends to meet a recognized need for clinician-scientists in Infectious Diseases who are trained in functional and applied genomics - a recognized strength at Stanford University School of Medicine. Trainees are expected to graduate to academic faculty appointments or to research-oriented positions in Federal or State government, public health or the biotechnology sector.

Public Health Relevance

The purpose of this proposal is to prepare qualified postdoctoral trainees in Infectious Diseases for careers that will have a significant impact on the health-related research needs of the Nation. The training program will exploit the world-class resources and leadership at the host institution in the field of genomics. Graduating trainees from this program will be unusually well-prepared to enhance the public health through the application of this powerful field of science.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
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Stanford University
Internal Medicine/Medicine
Schools of Medicine
United States
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Andermann, Tessa M; Rezvani, Andrew; Bhatt, Ami S (2016) Microbiota Manipulation With Prebiotics and Probiotics in Patients Undergoing Stem Cell Transplantation. Curr Hematol Malig Rep 11:19-28
Waldron, Paul Ravi; Belitskaya-Lévy, Ilana; Chary, Aarthi et al. (2016) Genetic Variation in the IL-6 and HLA-DQB1 Genes Is Associated with Spontaneous Clearance of Hepatitis C Virus Infection. J Immunol Res 2016:6530436
Schanz, Julie (2016) Helpful Tool or Oversimplification? Concept of the Monosomal Karyotype from the Clinical and Cytogenetic Point of View. Biol Blood Marrow Transplant 22:191-2
Tan, Susanna K; Waggoner, Jesse J; Pinsky, Benjamin A (2015) Cytomegalovirus load at treatment initiation is predictive of time to resolution of viremia and duration of therapy in hematopoietic cell transplant recipients. J Clin Virol 69:179-83
Bekerman, Elena; Einav, Shirit (2015) Response—Applying antibiotics lessons to antivirals. Science 348:1437
Kovackova, Sona; Chang, Lei; Bekerman, Elena et al. (2015) Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents. J Med Chem 58:3393-410
Waggoner, Jesse J; Sahadeo, Nikita S D; Brown, Arianne et al. (2015) Improved serotype-specific dengue virus detection in Trinidad and Tobago using a multiplex, real-time RT-PCR. Diagn Microbiol Infect Dis 81:105-6
Bekerman, Elena; Einav, Shirit (2015) Infectious disease. Combating emerging viral threats. Science 348:282-3
Waldron, Paul Ravi; Holodniy, Mark (2015) Peripheral Blood Mononuclear Cell Gene Expression Remains Broadly Altered Years after Successful Interferon-Based Hepatitis C Virus Treatment. J Immunol Res 2015:958231
Neveu, Gregory; Ziv-Av, Amotz; Barouch-Bentov, Rina et al. (2015) AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets. J Virol 89:4387-404

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