PI: CAMPBELL, LEE ANN Project: 2T32AI007509-11A1 Title: Diseases of Public Health Importance Accession Number: 12156281 ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM APPLICATION AND HAS NOT BEEN PROOFED BY AN SRA.WHEN THERE ARE PROBLEMS WITH THE APPLICATION SCANNING PROCESS, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE. ================== The specific objectives of the training program are to train graduate students and postdoctoral fellows in the application of principles and theories of modern biotechnology to specific disease problems. The Pathobiology program provides a link between molecular approaches and public health. This is supported by the course requirements in our graduate program which include core courses in Pathobiology emphasizing disease concepts, and courses in epidemiology, immunology, and molecular biology. The multiple research collaborations melding our laboratory-based training with other Public Health Disciplines offer unique opportunities to conduct multidisciplinary studies on diseases in human populations. There are several aspects that distinguish our training program: 1) A focus on pathogens with relevance to global health;2) An interdisciplinary approach to genetic or infectious contributors to chronic disease;3) A relevance to maternal prevention and intervention;4) An emphasis on emerging and re-emerging global health issues;5) A focus on new tools for prevention and intervention;and 6) A focus on identification of biomarkers. The Pathobiology training program has 41 training faculty members. The predoctoral training program in Pathobiology was approved by the University of Washington Graduate School in 1990 and received Interdisciplinary Program Status in 2006. We have graduated 70 PhDs since 1990. Of these 70, 45 have received ther PhD degreee since 2001. Since 1970, our faculty have trained over 470 postdoctoral fellows. The proposed training program will train 3 predoctoral and 3 postdoctoral trainees per year. The combination of diverse research and classroom environments provide a strong integrated approach to enable trainees to prepare for and deal most effectively with the impact of disease on global Public Health.

Public Health Relevance

;The specific objective our training program "Diseases of Public Health Importance" is to provide interdisciplinary training in basic sciences related to the etiology, pathogenesis, prevention, and cure of globally important diseases. The ultimate goal is to equip our future basic scientists to effectively combat infectious disease challenges through innovative research to find solutions toward global health needs

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Public Health & Prev Medicine
Schools of Medicine
United States
Zip Code
Kalidas, Savitha; Cestari, Igor; Monnerat, Severine et al. (2014) Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei. Eukaryot Cell 13:504-16
Bouchut, Anne; Geiger, Jennifer A; DeRocher, Amy E et al. (2014) Vesicles bearing Toxoplasma apicoplast membrane proteins persist following loss of the relict plastid or Golgi body disruption. PLoS One 9:e112096
Brownell, Jessica; Bruckner, Jacob; Wagoner, Jessica et al. (2014) Direct, interferon-independent activation of the CXCL10 promoter by NF-*B and interferon regulatory factor 3 during hepatitis C virus infection. J Virol 88:1582-90
Graham, Jessica B; Da Costa, Andreia; Lund, Jennifer M (2014) Regulatory T cells shape the resident memory T cell response to virus infection in the tissues. J Immunol 192:683-90
Zhang, Zhongsheng; Ojo, Kayode K; Vidadala, Ramasubbarao et al. (2014) Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. ACS Med Chem Lett 5:40-44
Austin, Laura S; Kaushansky, Alexis; Kappe, Stefan H I (2014) Susceptibility to Plasmodium liver stage infection is altered by hepatocyte polyploidy. Cell Microbiol 16:784-95
Ronen, Keshet; McCoy, Connor O; Matsen, Frederick A et al. (2013) HIV-1 superinfection occurs less frequently than initial infection in a cohort of high-risk Kenyan women. PLoS Pathog 9:e1003593
Cestari, Igor; Stuart, Kenneth (2013) A spectrophotometric assay for quantitative measurement of aminoacyl-tRNA synthetase activity. J Biomol Screen 18:490-7
Gamez, Beatriz; Rodriguez-Carballo, Edgardo; Bartrons, Ramon et al. (2013) MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability. J Biol Chem 288:14264-75
Davenport, Thaddeus M; Guttman, Miklos; Guo, Wenjin et al. (2013) Isolate-specific differences in the conformational dynamics and antigenicity of HIV-1 gp120. J Virol 87:10855-73

Showing the most recent 10 out of 48 publications