The primary goals of the proposed training program are first to recruit talented and highly-motivated graduate students and second to provide them with first-rate training that will prepare them for careers in academic research as competitive, independent investigators. The program faculty's research interests span a wide range of questions regarding host-microbe interactions and related topics in pathogenesis, which allows the entering trainee a considerable breadth of choice of experimental systems, approaches, and research topics. Training options include animal and human systems, thus enhancing our ability to attract and train Ph.D. and M.D./Ph.D. students for research careers. Another strength of the proposed training grant is the quality of the research programs of the participating faculty. This proposal includes 19 well-funded program faculty members who have productive, timely, and energetic research efforts in numerous areas of current interest. Particular areas of strength are molecular genetics of bacterial, parasitic, and viral pathogenesis;cellular and immunobiology of parasites;B cell activation and interaction with T helper cells and lymphokines;mucosal immune responses;signaling events in host-pathogen interactions;involvement of various immune mechanisms in resistance to infectious diseases including those caused by bacteria, fungi, parasites and retroviruses such as HIV and mouse AIDS (MAIDS) virus;immunotherapeutics and vaccine design. These areas are pursued using the full range of modern genetic, immunblogic, biochemical, and molecular biologic techniques. We have outstanding facilities and resources to facilitate the application of these techniques, including new or renovated laboratories. The proposal also benefits from the presence of strong existing graduate programs leading to the Ph.D. degree. Training in molecular pathogenesis spans six departments that encompass two graduate programs - Molecular and Cellular Biology and Program in Experimental and Molecular Medicine - with the former containing the majority of the participating faculty and students. Consistent with this organization, graduate training in molecular pathogenesis at Dartmouth is an interdisciplinary approach that is nurtured by a highly interactive environment in which the trainees are regularly exposed to diverse areas of faculty expertise, from clinical to basic science studies, in a variety of forums, including a number of advanced courses, weekly seminar series and journal clubs, and retreats.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
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Dartmouth College
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Fox, Barbara A; Rommereim, Leah M; Guevara, Rebekah B et al. (2016) The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection. MBio 7:
Parker, Zachary M; Pasieka, Tracy Jo; Parker, George A et al. (2016) Immune- and Nonimmune-Compartment-Specific Interferon Responses Are Critical Determinants of Herpes Simplex Virus-Induced Generalized Infections and Acute Liver Failure. J Virol 90:10789-10799
Rommereim, Leah M; Bellini, Valeria; Fox, Barbara A et al. (2016) Phenotypes Associated with Knockouts of Eight Dense Granule Gene Loci (GRA2-9) in Virulent Toxoplasma gondii. PLoS One 11:e0159306
Kowalski, Caitlin H; Beattie, Sarah R; Fuller, Kevin K et al. (2016) Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence. MBio 7:
Gao, Yang; Hauke, Caitlyn A; Marles, Jarrad M et al. (2016) Effects of tcpB Mutations on Biogenesis and Function of the Toxin-Coregulated Pilus, the Type IVb Pilus of Vibrio cholerae. J Bacteriol 198:2818-28
Cooley, Richard B; Smith, T Jarrod; Leung, Wilfred et al. (2016) Cyclic Di-GMP-Regulated Periplasmic Proteolysis of a Pseudomonas aeruginosa Type Vb Secretion System Substrate. J Bacteriol 198:66-76
Bahl, Christopher D; Hvorecny, Kelli L; Morisseau, Christophe et al. (2016) Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif. Biochemistry 55:788-97
Rosato, Pamela C; Katzenell, Sarah; Pesola, Jean M et al. (2016) Neuronal IFN signaling is dispensable for the establishment of HSV-1 latency. Virology 497:323-7
Hollomon, Jeffrey M; Grahl, Nora; Willger, Sven D et al. (2016) Global Role of Cyclic AMP Signaling in pH-Dependent Responses in Candida albicans. mSphere 1:
Parker, Zachary M; Murphy, Aisling A; Leib, David A (2015) Role of the DNA Sensor STING in Protection from Lethal Infection following Corneal and Intracerebral Challenge with Herpes Simplex Virus 1. J Virol 89:11080-91

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