Vaccination is one of the most cost-effective approaches in preventive medicine. Over the past 3 decades, new techniques in recombinant DNA and biotechnology have offered unprecedented opportunities for developing new vaccines. Many training opportunities exist to prepare individuals for research in immunology, molecular genetics, infectious diseases, and other specific aspects of vaccine development, but few training programs offer broad exposure to both laboratory and clinical trial aspects of vaccinology as a cohesive discipline. For the past 37 years, the Center for Vaccine Development of the University of Maryland School of Medicine has been involved in all aspects of vaccine development, from basic laboratory studies involving genetic construction of recombinant vaccines to Phase 1 through Phase 4 clinical trials. We propose to continue a formal training program in which individuals with M.D. or Ph.D. (or equivalent) degrees can be prepared specifically for careers in vaccinology, either to pursue basic vaccine development research or to conduct investigative clinical trials and translational research. Two new trainees will join the training program in each of the five years and training for each trainee will ensue fr 3 (sometimes 4) years. Support only for years 1 and 2 is requested in this proposal;support for the 3rd and possible 4th years will come from fellowships, research grants, or other sources. The Training Program in Vaccinology offers to all trainees a broad exposure to both the laboratory and clinical trial phases of vaccinology. Beyond this broad exposure, the program has two tracks to provide each trainee with intensive experience in either the laboratory aspects or the clinical phases of vaccinology, depending upon which track they choose. The Laboratory Track allows the training of basic scientists and physician-scientists in vaccine development laboratory research, particularly in the use of recombinant DNA technology to prepare new vaccine candidates and the use of modern immunological techniques to study the human humoral and cellular immune response to vaccines. The Clinical Track trains clinicians (internists or pediatricians) in trial design, protocol development, regulatory and ethical clearances, performance of clinical trials, data analysis and clinical translational research. The ultimate goal of this training program is to provide a well-trained cadre of individuals who can fully exploit the unprecedented opportunities now available in vaccine development.

Public Health Relevance

Vaccines developed during the past few decades have been able to protect children and adults from infectious diseases that caused suffering and death in past generations. The tools of modern science allow new vaccines to be designed and tested and made available to protect the health of our population. We propose to continue our Training Program that trains scientists in how to develop new vaccines and doctors in how to test the candidate new vaccines in step-wise fashion to the point where we are sure of their safety and their ability to protect the public against infectious diseases that were not previously preventable.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases B Subcommittee (MID)
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Robbins, Christiane M
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University of Maryland Baltimore
Internal Medicine/Medicine
Schools of Medicine
United States
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Boyd, Mary Adetinuke; Tennant, Sharon M; Saague, Venant A et al. (2014) Serum bactericidal assays to evaluate typhoidal and nontyphoidal Salmonella vaccines. Clin Vaccine Immunol 21:712-21
Simon, Raphael; Tennant, Sharon M; Galen, James E et al. (2011) Mouse models to assess the efficacy of non-typhoidal Salmonella vaccines: revisiting the role of host innate susceptibility and routes of challenge. Vaccine 29:5094-106
Simon, Raphael; Tennant, Sharon M; Wang, Jin Y et al. (2011) Salmonella enterica serovar enteritidis core O polysaccharide conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with S. enteritidis. Infect Immun 79:4240-9
Tennant, Sharon M; Wang, Jin-Yuan; Galen, James E et al. (2011) Engineering and preclinical evaluation of attenuated nontyphoidal Salmonella strains serving as live oral vaccines and as reagent strains. Infect Immun 79:4175-85
Gat, Orit; Galen, James E; Tennant, Sharon et al. (2011) Cell-associated flagella enhance the protection conferred by mucosally-administered attenuated Salmonella Paratyphi A vaccines. PLoS Negl Trop Dis 5:e1373
Chen, Wilbur H; Basu, Subhendu; Bhattacharjee, Apurba K et al. (2010) Enhanced antibody responses to a detoxified lipopolysaccharide-group B meningococcal outer membrane protein vaccine are due to synergistic engagement of Toll-like receptors. Innate Immun 16:322-32
Chen, Wilbur H; Kang, Tae Jin; Bhattacharjee, Apurba K et al. (2008) Intranasal administration of a detoxified endotoxin vaccine protects mice against heterologous Gram-negative bacterial pneumonia. Innate Immun 14:269-78
Lombardo, Mary-Jane; Michalski, Jane; Martinez-Wilson, Hector et al. (2007) An in vivo expression technology screen for Vibrio cholerae genes expressed in human volunteers. Proc Natl Acad Sci U S A 104:18229-34
Buckles, Eric L; Bahrani-Mougeot, Farah K; Molina, Anita et al. (2004) Identification and characterization of a novel uropathogenic Escherichia coli-associated fimbrial gene cluster. Infect Immun 72:3890-901
Campbell, James D; Lagos, Rosanna; Levine, Myron M et al. (2002) Standard and alternative regimens of Haemophilus influenzae type b conjugate vaccine (polyribosylribitol phosphate-tetanus toxoid conjugate vaccine) elicit comparable antibody avidities in infants. Pediatr Infect Dis J 21:822-6

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