Funds are requested for renewal of a pre-doctoral Emerging and Tropical Infectious Diseases Training Program to support four trainees. Training is provided by 16 Program faculty. Emerging and tropical infectious diseases encompass the broad-based multidisciplinary sciences of microbiology, pathology, immunology, molecular biology, epidemiology, entomology, vertebrate zoology, biochemistry and cell biology, with this proposal focusing on "Vector-borne diseases". The University of Texas Medical Branch (UTMB) at Galveston has made a major commitment to emerging and tropical diseases, including designation as a WHO Collaborating Center for Tropical Diseases, which provides trainees of this program to a very attractive array of research areas and resources highly relevant to emerging and tropical infectious diseases. In addition, the faculty have current federal grant support for research on emerging infections and tropical diseases in the United States, Mexico, South America and Africa. Thus the trainees will have opportunities to undertake a variety of potential research topics from laboratory-based studies at UTMB to field studies in the tropics. Formal course work is completed in the first two years affording the trainee with a comprehensive background in infectious disease concepts;laboratory rotations familiarize the students with state-of-the-art technology and facilities, and orient them to potential future mentors. The students select mentors during the first and early part of the second year and prepare and defend a research dissertation topic in consultation with a research committee. The research is then conducted, culminating in the dissertation and defense. The pre-doctoral trainees have access to state-of-the-art facilities at UTMB including arthropod containment level (ACL) -2, ACL-3, BSL-3, animal BSL-3 and BSL-4. They participate in multiple research seminar series including Frontiers of Infectious Disease and Tropical Medicine, and they present their own research results in the above and other Research-in-Progress seminar series. Most of the former trainees embark on post-doctoral fellowships, and assume positions of responsibility at medical and graduate schools, colleges and as staff of research institutes and industry.

Public Health Relevance

Emerging and Tropical infections are important areas of public health. There are insufficient trained investigators to undertake research in these fields. This grant will address this shortage by training the outstanding investigators of the future in a dynamic training environment.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases Research Committee (MID)
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Robbins, Christiane M
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University of Texas Medical Br Galveston
Schools of Medicine
United States
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Plante, Jessica A; Burkhalter, Kristen L; Mann, Brian R et al. (2014) Co-circulation of West Nile virus variants, Arizona, USA, 2010. Emerg Infect Dis 20:272-5
Henard, Calvin A; Carlsen, Eric D; Hay, Christie et al. (2014) Leishmania amazonensis amastigotes highly express a tryparedoxin peroxidase isoform that increases parasite resistance to macrophage antimicrobial defenses and fosters parasite virulence. PLoS Negl Trop Dis 8:e3000
Willias, Stephan P; Chauhan, Sadhana; Motin, Vladimir L (2014) Functional characterization of Yersinia pestis aerobic glycerol metabolism. Microb Pathog 76:33-43
Mann, Brian R; McMullen, Allison R; Swetnam, Daniele M et al. (2013) Continued evolution of West Nile virus, Houston, Texas, USA, 2002-2012. Emerg Infect Dis 19:1418-27
McMullen, Allison R; Albayrak, Harun; May, Fiona J et al. (2013) Molecular evolution of lineage 2 West Nile virus. J Gen Virol 94:318-25
Rossi, Shannan L; Guerbois, Mathilde; Gorchakov, Rodion et al. (2013) IRES-based Venezuelan equine encephalitis vaccine candidate elicits protective immunity in mice. Virology 437:81-8
Carlsen, Eric D; Hay, Christie; Henard, Calvin A et al. (2013) Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms. Infect Immun 81:3966-74
Mann, Brian R; McMullen, Allison R; Swetnam, Daniele M et al. (2013) Molecular epidemiology and evolution of West Nile virus in North America. Int J Environ Res Public Health 10:5111-29
Wicker, Jason A; Whiteman, Melissa C; Beasley, David W C et al. (2012) Mutational analysis of the West Nile virus NS4B protein. Virology 426:22-33
Heinze, Dar M; Wikel, Stephen K; Thangamani, Saravanan et al. (2012) Transcriptional profiling of the murine cutaneous response during initial and subsequent infestations with Ixodes scapularis nymphs. Parasit Vectors 5:26

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