This revised application seeks continued support at the pre-doctoral and post-doctoral level for a Training Program in Molecular Mechanisms of Microbial Pathogenesis (MMMP) at the University of Michigan. In the MMMP Ph.D. training program, students select thesis advisors from among a number of trainers whose research covers broad aspects of infection and immunity. Trainers are bacteriologists, virologists, immunologists, cell biologists and biochemists who use a range of tools to study microbial pathogenesis and the host response. An interdisciplinary Ph.D. curriculum covers basic topics such as biochemistry, genetics and cell biology and other elective courses, as well as required courses in bacterial and viral pathogenesis, pathology, and immunology. All trainees (both pre- and post-doctoral) participate in a research seminar course (Microbiology and Immunology 812) and an MMMP Program-specific course called """"""""Science in the Clinics"""""""", which correlates the molecular and cellular mechanisms of pathogenesis with pathophysiology and symptomology of infectious disease. Attendance at ID Grand Rounds is included in this course. A Program-sponsored seminar series entitled """"""""Young Investigators in Pathogenesis"""""""" brings investigators from other institutions to Michigan to present their work and discuss their career paths with MMMP trainees. MMMP pre-doctoral candidates are recruited from the larger pool of graduate applicants to the University of Michigan, based on their background and interest in pathogenesis. Before the end of their first year at Michigan, MMMP Program trainees will join the comprehensive program of coursework and research leading to a Ph.D. The vast majority of MMMP trainees obtain their Ph.D. in Microbiology and Immunology, although a small number obtain their degrees in cognate disciplines such as Cell and Molecular Biology or Epidemiology. Post-doctoral candidates will be recruited to the program through two mechanisms: i) by identifying graduate students elsewhere who are publishing in the field of microbial pathogenesis and inviting them to visit Michigan to consider post-doctoral work in the MMMP Program and ii) from among those nominated by mentors in the Program.

Public Health Relevance

The trainees in this program constitute the next generation of investigators in the field of microbial pathogenesis. They have the potential to make important contributions by uncovering new knowledge about infectious diseases and/or translating knowledge to new diagnostics and therapeutics, thereby having a significant positive influence on public health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007528-14
Application #
8294624
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
1998-09-30
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
14
Fiscal Year
2012
Total Cost
$351,521
Indirect Cost
$20,554
Name
University of Michigan Ann Arbor
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Abbott, Zachary D; Flynn, Kaitlin J; Byrne, Brenda G et al. (2016) csrT Represents a New Class of csrA-Like Regulatory Genes Associated with Integrative Conjugative Elements of Legionella pneumophila. J Bacteriol 198:553-64
McCarthy, Mary K; Malitz, Danielle H; Molloy, Caitlyn T et al. (2016) Interferon-dependent immunoproteasome activity during mouse adenovirus type 1 infection. Virology 498:57-68
Leslie, Jhansi L; Young, Vincent B (2016) A whole new ball game: Stem cell-derived epithelia in the study of host-microbe interactions. Anaerobe 37:25-8
Todd, Gabrielle C; Duchon, Alice A; Inlora, Jingga et al. (2016) Inhibition of HIV-1 Gag-membrane interactions by specific RNAs. RNA :
Procario, Megan C; McCarthy, Mary K; Levine, Rachael E et al. (2016) Prostaglandin E2 production during neonatal respiratory infection with mouse adenovirus type 1. Virus Res 214:26-32
Menachery, Vineet D; Yount Jr, Boyd L; Sims, Amy C et al. (2016) SARS-like WIV1-CoV poised for human emergence. Proc Natl Acad Sci U S A 113:3048-53
Collins, David R; Lubow, Jay; Lukic, Zana et al. (2015) Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes. PLoS Pathog 11:e1005054
Contreras-Galindo, Rafael; Kaplan, Mark H; Dube, Derek et al. (2015) Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K-Related Sequences. J Virol 89:7187-201
Baxter, Nielson T; Wan, Judy J; Schubert, Alyxandria M et al. (2015) Intra- and interindividual variations mask interspecies variation in the microbiota of sympatric peromyscus populations. Appl Environ Microbiol 81:396-404
McCarthy, Mary K; Procario, Megan C; Wilke, Carol A et al. (2015) Prostaglandin E2 Production and T Cell Function in Mouse Adenovirus Type 1 Infection following Allogeneic Bone Marrow Transplantation. PLoS One 10:e0139235

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