This renewal application requests continued support of our post-doctoral training program in Pediatric Infectious Diseases at Columbia University Medical Center. Pediatric Infectious Diseases continues to be a critically important discipline as it seeks to increase our understanding of the pathogenesis and treatment of infectious diseases in infants, children, and adolescents. Our program has been funded since 1998 and has graduated 14 physicians in pediatric ID, all of whom are now engaged in academic endeavors. Three additional post-doctoral trainees are currently in training. Our trainees have performed basic, translational, clinical, and epidemiologic research in host-pathogen interactions;virulence factors;emerging pathogens;molecular epidemiology;safety and efficacy of vaccines;antimicrobial resistance and antimicrobial stewardship;and healthcare-associated infections. The objective of our program continues to be to train physician-scientists for careers in basic, translational, clinical, and epidemiologic research in academic settings and/or in the public health sector. In this proposed project period the research activities of the training program will reflect three complementary areas of research related to host-pathogen interactions which will include: bacterial/ viral pathogenesis;safety and effectiveness of vaccines;and public health and healthcare delivery. Thus, the faculty mentors described on this training grant are highly interdisciplinary and reflect the outstanding academic resources available at Columbia University Medical Center. Our faculty mentors are from the Departments of Pediatrics, Medicine, Microbiology &Immunology, Pathology &Cell Biology, Obstetrics &Gynecology, Pharmacology, and Psychiatry as well as the School of Nursing and the Mailman School of Public Health. Our training program in Pediatric Infectious Diseases lasts for 3 years. In this renewal application, we are requesting 5 more years of funding for 3 post-doctoral fellow trainees per year: one 1st year, one 2nd year, and one 3rd year trainee each year. During the 3-year program, the trainees engage in scholarly research guided by an experienced mentor. The trainees also acquire clinical expertise in Pediatric Infectious Diseases and are eligible to be board certified in this discipline at the end of their training. Thanks to this training grant and he strong program we have developed, we continue to recruit outstanding applicants who have completed their pediatric residencies, seek to develop their research skills in Pediatric Infectiou Diseases, and have the goal of pursuing academic endeavors in university or public health settings upon completion of their training.

Public Health Relevance

The discipline of pediatric infectious diseases is critically important to increase our understanding of the care of infants, children and adolescents with infections caused by bacteria, viruses, or fungi or who are at risk of getting an infectious disease. This program trains pediatricians to perform basic, clinical, and/or epidemiologic research in human-pathogen interactions;safety and effectiveness of vaccines;and public health including emerging infectious agents, resistance to antibiotics, and healthcare- associated infections.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases Research Committee (MID)
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Robbins, Christiane M
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Columbia University (N.Y.)
Schools of Medicine
New York
United States
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Zucker, Jason; Neu, Natalie; Chiriboga, Claudia A et al. (2017) Zika Virus-Associated Cognitive Impairment in Adolescent, 2016. Emerg Infect Dis 23:1047-1048
Anderson, Brett R; Blancha, Victoria L; Duchon, Jennifer M et al. (2017) The effects of postoperative hematocrit on shunt occlusion for neonates undergoing single ventricle palliation. J Thorac Cardiovasc Surg 153:947-955
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Zachariah, Philip; Stockwell, Melissa S (2016) Measles vaccine: Past, present, and future. J Clin Pharmacol 56:133-40
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Sen, Anita I; Balzer, Krystal; Mangino, Diane et al. (2016) Electronic surveillance for catheter-associated urinary tract infections at a university-affiliated children's hospital. Am J Infect Control 44:599-601
Subramony, Anupama; Zachariah, Philip; Krones, Ariella et al. (2016) Impact of Multiplex Polymerase Chain Reaction Testing for Respiratory Pathogens on Healthcare Resource Utilization for Pediatric Inpatients. J Pediatr 173:196-201.e2
Zachariah, Philip; Newland, Jason G; Gerber, Jeffrey S et al. (2016) Costs of Antimicrobial Stewardship Programs at US Children's Hospitals. Infect Control Hosp Epidemiol 37:852-4
Neu, Natalie; Duchon, Jennifer; Zachariah, Philip (2015) TORCH infections. Clin Perinatol 42:77-103, viii

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