Penn has a vibrant program in Parasitology and between 1965 and 2004 the Graduate Group in Parasitology awarded approximately 75 Ph.D. degrees and 17 MS degrees. In 2004 a new Graduate Group, the Microbiology, Virology and Parasitology (MVP) program was formed. This has resulted in increased numbers of students with broad interests in Microbiology being exposed to course work devoted to understanding parasitic systems and increased numbers of students graduating from Parasitology laboratories. Members of this T32 program have diverse interests and study at least 11 different parasitic infections. There are several major research themes within this faculty that include immunoparasitology, cell and molecular biology of these organism, as well as their population biology. These form the underlying core of our program. The faculty participants in this proposal have primary appointments in 10 different departments within the Schools of Medicine, Veterinary Medicine and Arts and Sciences. In addition, in the last 10 years our faculty have served as advisors or sponsors for over 100 postdoctoral fellows and 90 graduate students. The majority of these trainees have gone on to successful careers in Parasitology or related disciplines. Each faculty member offers strong research training in a basic science discipline as it relates to Parasitology. As a group, we also offer didactic training in parasitology and provide an environment in which students and post-doctoral fellows will gain an appreciation for broader aspects of parasitic disease research. The goal of this program is to provide pre-doctoral students with strong research training in specific basic science disciplines in combination with broad training in parasitology. While faculty membership has changed over time, these overall goals remain the guiding principle of this training grant.

Public Health Relevance

Half of the world's population live in malaria-endemic areas, two billion people on Earth are infected by soil-transmitted helminths while forgotten parasitic diseases that include leishmaniasis, filariasis, toxoplasmosis, and trypanosomiasis contribute to the public health burden. Despite the recognition that there is a need to study parasitic diseases, opportunities to get a broad education in this topic remain limited. The goal of this program is to provide pre-doctoral students with strong research training in specific basic science disciplines in combination with broad training in parasitology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI007532-16
Application #
8550927
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
1998-09-30
Project End
2018-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
16
Fiscal Year
2013
Total Cost
$227,053
Indirect Cost
$10,893
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Liu, Weimin; Sundararaman, Sesh A; Loy, Dorothy E et al. (2016) Multigenomic Delineation of Plasmodium Species of the Laverania Subgenus Infecting Wild-Living Chimpanzees and Gorillas. Genome Biol Evol 8:1929-39
Beltrame, Marcia Holsbach; Rubel, Meagan A; Tishkoff, Sarah A (2016) Inferences of African evolutionary history from genomic data. Curr Opin Genet Dev 41:159-166
Loy, Dorothy E; Liu, Weimin; Li, Yingying et al. (2016) Out of Africa: origins and evolution of the human malaria parasites Plasmodium falciparum and Plasmodium vivax. Int J Parasitol :
Guggisberg, Ann M; Sundararaman, Sesh A; Lanaspa, Miguel et al. (2016) Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure With Fosmidomycin-Clindamycin. J Infect Dis 214:1085-91
Sundararaman, Sesh A; Plenderleith, Lindsey J; Liu, Weimin et al. (2016) Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria. Nat Commun 7:11078
Menger, David J; Omusula, Philemon; Wouters, Karlijn et al. (2016) Eave Screening and Push-Pull Tactics to Reduce House Entry by Vectors of Malaria. Am J Trop Med Hyg 94:868-78
Monticelli, Laurel A; Buck, Michael D; Flamar, Anne-Laure et al. (2016) Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nat Immunol 17:656-65
Monticelli, Laurel A; Osborne, Lisa C; Noti, Mario et al. (2015) IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions. Proc Natl Acad Sci U S A 112:10762-7
Harms Pritchard, Gretchen; Hall, Aisling O'Hara; Christian, David A et al. (2015) Diverse roles for T-bet in the effector responses required for resistance to infection. J Immunol 194:1131-40
Wojno, E D Tait; Monticelli, L A; Tran, S V et al. (2015) The prostaglandin Dâ‚‚ receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung. Mucosal Immunol 8:1313-23

Showing the most recent 10 out of 96 publications