Support is requested for continuation of a postdoctoral training program in emerging infectious diseases and biodefense that would support 6 trainees annually and prepare them for clinical, epidemiological, applied or basic research careers in this field. Training will be provided by 21 Program Faculty and 15 Associate Program Faculty in the departments of Pathology, Internal Medicine, Microbiology and Immunology, Pediatrics, Biochemistry and Molecular Biology and Preventive Medicine and Community Health at the University of Texas Medical Branch (UTMB). Faculty include a number ot former trainees. Other resources available at UTMB for the training program include the Center for Biodefense and Emerging Infectious Diseases, the Western Regional Center for Biodefense and Emerging Infectious Diseases, the Institute for Human Infections and Immunity, the Center for Hepatitis Research, the Sealy Center for Vaccine Development, the Keck Center for Virus Imaging, the Sealy Center for Structural Biology, the Galveston National Laboratory, the WHO/PAHO Collaborating Center for Tropical Diseases, and the Galveston Global Health Consortium. There is currently a shortage of trained research scientists with the knowledge and experience necessary to work with emerging infectious disease agents or NIAID category A, B, and C priority pathogens. UTMB now has a critical mass of outstanding faculty and support personnel working the this area, including state-of-the-art containment facilities needed to work with highly pathogenic organisms. The program's goal is leverage the rich and vibrant research environment at UTMB to enable trainees to become independent investigators within the broad field of emerging infectious diseases and biodefense.

Public Health Relevance

Emerging infections and biodefense are important areas of research and there are not enough trained investigators in these fields. This grant will address this shortage by training outstanding.investigators in a dynamic training environment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007536-15
Application #
8462193
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
1998-08-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
15
Fiscal Year
2013
Total Cost
$367,060
Indirect Cost
$31,861
Name
University of Texas Medical Br Galveston
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Vittor, Amy Y; Armien, Blas; Gonzalez, Publio et al. (2016) Epidemiology of Emergent Madariaga Encephalitis in a Region with Endemic Venezuelan Equine Encephalitis: Initial Host Studies and Human Cross-Sectional Study in Darien, Panama. PLoS Negl Trop Dis 10:e0004554
Phoenix, Inaia; Nishiyama, Shoko; Lokugamage, Nandadeva et al. (2016) N-Glycans on the Rift Valley Fever Virus Envelope Glycoproteins Gn and Gc Redundantly Support Viral Infection via DC-SIGN. Viruses 8:
Sarathy, Vanessa V; Infante, Ernesto; Li, Li et al. (2015) Characterization of lethal dengue virus type 4 (DENV-4) TVP-376 infection in mice lacking both IFN-α/β and IFN-γ receptors (AG129) and comparison with the DENV-2 AG129 mouse model. J Gen Virol 96:3035-48
Yun, Tatyana; Park, Arnold; Hill, Terence E et al. (2015) Efficient reverse genetics reveals genetic determinants of budding and fusogenic differences between Nipah and Hendra viruses and enables real-time monitoring of viral spread in small animal models of henipavirus infection. J Virol 89:1242-53
Whiteman, Melissa C; Popov, Vsevolod; Sherman, Michael B et al. (2015) Attenuated West Nile virus mutant NS1130-132QQA/175A/207A exhibits virus-induced ultrastructural changes and accumulation of protein in the endoplasmic reticulum. J Virol 89:1474-8
Sarathy, Vanessa V; Milligan, Gregg N; Bourne, Nigel et al. (2015) Mouse models of dengue virus infection for vaccine testing. Vaccine 33:7051-60
Opata, Michael M; Carpio, Victor H; Ibitokou, Samad A et al. (2015) Early effector cells survive the contraction phase in malaria infection and generate both central and effector memory T cells. J Immunol 194:5346-54
Milligan, Gregg N; Sarathy, Vanessa V; Infante, Ernesto et al. (2015) A Dengue Virus Type 4 Model of Disseminated Lethal Infection in AG129 Mice. PLoS One 10:e0125476
Pitcher, Trevor J; Sarathy, Vanessa V; Matsui, Kiyohiko et al. (2015) Functional analysis of dengue virus (DENV) type 2 envelope protein domain 3 type-specific and DENV complex-reactive critical epitope residues. J Gen Virol 96:288-93
Santiago, Felix W; Halsey, Eric S; Siles, Crystyan et al. (2015) Long-Term Arthralgia after Mayaro Virus Infection Correlates with Sustained Pro-inflammatory Cytokine Response. PLoS Negl Trop Dis 9:e0004104

Showing the most recent 10 out of 95 publications