Support is requested for continuation of a postdoctoral training program in emerging infectious diseases and biodefense that would support 6 trainees annually and prepare them for clinical, epidemiological, applied or basic research careers in this field. Training will be provided by 21 Program Faculty and 15 Associate Program Faculty in the departments of Pathology, Internal Medicine, Microbiology and Immunology, Pediatrics, Biochemistry and Molecular Biology and Preventive Medicine and Community Health at the University of Texas Medical Branch (UTMB). Faculty include a number ot former trainees. Other resources available at UTMB for the training program include the Center for Biodefense and Emerging Infectious Diseases, the Western Regional Center for Biodefense and Emerging Infectious Diseases, the Institute for Human Infections and Immunity, the Center for Hepatitis Research, the Sealy Center for Vaccine Development, the Keck Center for Virus Imaging, the Sealy Center for Structural Biology, the Galveston National Laboratory, the WHO/PAHO Collaborating Center for Tropical Diseases, and the Galveston Global Health Consortium. There is currently a shortage of trained research scientists with the knowledge and experience necessary to work with emerging infectious disease agents or NIAID category A, B, and C priority pathogens. UTMB now has a critical mass of outstanding faculty and support personnel working the this area, including state-of-the-art containment facilities needed to work with highly pathogenic organisms. The program's goal is leverage the rich and vibrant research environment at UTMB to enable trainees to become independent investigators within the broad field of emerging infectious diseases and biodefense.

Public Health Relevance

Emerging infections and biodefense are important areas of research and there are not enough trained investigators in these fields. This grant will address this shortage by training outstanding.investigators in a dynamic training environment.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
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University of Texas Medical Br Galveston
Internal Medicine/Medicine
Schools of Medicine
United States
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Milligan, Gregg N; Sarathy, Vanessa V; White, Mellodee M et al. (2017) A lethal model of disseminated dengue virus type 1 infection in AG129 mice. J Gen Virol 98:2507-2519
Nishiyama, Shoko; Slack, Olga A L; Lokugamage, Nandadeva et al. (2016) Attenuation of pathogenic Rift Valley fever virus strain through the chimeric S-segment encoding sandfly fever phlebovirus NSs or a dominant-negative PKR. Virulence 7:871-881
Phoenix, Inaia; Nishiyama, Shoko; Lokugamage, Nandadeva et al. (2016) N-Glycans on the Rift Valley Fever Virus Envelope Glycoproteins Gn and Gc Redundantly Support Viral Infection via DC-SIGN. Viruses 8:
Vittor, Amy Y; Armien, Blas; Gonzalez, Publio et al. (2016) Epidemiology of Emergent Madariaga Encephalitis in a Region with Endemic Venezuelan Equine Encephalitis: Initial Host Studies and Human Cross-Sectional Study in Darien, Panama. PLoS Negl Trop Dis 10:e0004554
Opata, Michael M; Carpio, Victor H; Ibitokou, Samad A et al. (2015) Early effector cells survive the contraction phase in malaria infection and generate both central and effector memory T cells. J Immunol 194:5346-54
Whiteman, Melissa C; Popov, Vsevolod; Sherman, Michael B et al. (2015) Attenuated West Nile virus mutant NS1130-132QQA/175A/207A exhibits virus-induced ultrastructural changes and accumulation of protein in the endoplasmic reticulum. J Virol 89:1474-8
Sarathy, Vanessa V; White, Mellodee; Li, Li et al. (2015) A lethal murine infection model for dengue virus 3 in AG129 mice deficient in type I and II interferon receptors leads to systemic disease. J Virol 89:1254-66
Santiago, Felix W; Halsey, Eric S; Siles, Crystyan et al. (2015) Long-Term Arthralgia after Mayaro Virus Infection Correlates with Sustained Pro-inflammatory Cytokine Response. PLoS Negl Trop Dis 9:e0004104
Sarathy, Vanessa V; Infante, Ernesto; Li, Li et al. (2015) Characterization of lethal dengue virus type 4 (DENV-4) TVP-376 infection in mice lacking both IFN-?/? and IFN-? receptors (AG129) and comparison with the DENV-2 AG129 mouse model. J Gen Virol 96:3035-48
Ikegami, Tetsuro; Hill, Terence E; Smith, Jennifer K et al. (2015) Rift Valley Fever Virus MP-12 Vaccine Is Fully Attenuated by a Combination of Partial Attenuations in the S, M, and L Segments. J Virol 89:7262-76

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