Support for a third funding cycle of the predoctoral training Program entitled "Molecular and Cell Biology of Infectious Diseases". The training Program will be based in the Department of Molecular Genetics and Microbiology at Stony Brook University, 8 of whose faculty are proposed mentors. With an additional 12 outstanding faculty mentors from other University Departments, and nearby Brookhaven National Laboratories, the Program will train predoctoral students for a productive career in infectious disease research. Training will consist of lecture and laboratory courses in Genetics, Biochemistry, Molecular Biology, Cell Biology, Immunology, Microbial Pathogenesis and Scientific Ethics that will prepare students for thesis research. Students who show the most promise, based on their undergraduate academic performance and their achievements In graduate course work, laboratory rotations and qualifying exams, will be admitted to the Program beginning in the third year of graduate school for a 2- to 3-year period. All faculty mentors have a common interest in teaching and investigating the pathogenesis of infectious diseases at the molecular and cellular levels. All faculty mentors in the Program have individual NIH grants or other forms of support. The areas of thesis research training available to students include: a) bacterial pathogenesis;b) fungal virulence mechanisms;c) viral pathogenesis and replication;d) regulation of pathogen gene and protein expression;e) control of viral packaging and capsid assembly;f) development of diagnostics, drugs and vaccines against pathogens, g) innate immune responses to pathogens, and h) pathogenesis of Category A agents. The Program is overseen by a Director and Executive Committee and has a strong record of collaboration among faculty and students. The Program includes a robust mechanism for evaluating and improving all aspects of the training environment and for tracking the success of previous trainees for a period of up to 10 years. Nine of 10 trainees that have completed the Program since its inception remain in research/teaching positions and trainees generated 28 research publications during the period of support. The application requests support for 5 years, with 4 trainees requested in years 1-2, and 5 in years 3-5.

Public Health Relevance

The MCBID Program will provide high-quality training in research and career development for predoctoral scientists. The ultimate goal is to foster the development of the future leaders in the field of infectious disease research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007539-14
Application #
8301676
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
1998-09-30
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
14
Fiscal Year
2012
Total Cost
$175,673
Indirect Cost
$10,733
Name
State University New York Stony Brook
Department
Genetics
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Cieniewicz, Brandon; Carpino, Nicholas; Krug, Laurie T (2014) Enhanced response of T cells from murine gammaherpesvirus 68-infected mice lacking the suppressor of T cell receptor signaling molecules Sts-1 and Sts-2. PLoS One 9:e90196
Bublitz, DeAnna C; Wright, Patricia C; Bodager, Jonathan R et al. (2014) Epidemiology of pathogenic enterobacteria in humans, livestock, and peridomestic rodents in rural Madagascar. PLoS One 9:e101456
Khan, Shaukat; Toyoda, Hidemi; Linehan, Melissa et al. (2014) Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation. J Gen Virol 95:1668-76
DelGiorno, Kathleen E; Tam, Jason W; Hall, Jason C et al. (2014) Persistent salmonellosis causes pancreatitis in a murine model of infection. PLoS One 9:e92807
Guimet, Diana; Hearing, Patrick (2013) The adenovirus L4-22K protein has distinct functions in the posttranscriptional regulation of gene expression and encapsidation of the viral genome. J Virol 87:7688-99
Thomas-Charles, Cindy A; Zheng, Huaixin; Palmer, Lance E et al. (2013) FeoB-mediated uptake of iron by Francisella tularensis. Infect Immun 81:2828-37
Wu, Kai; Guimet, Diana; Hearing, Patrick (2013) The adenovirus L4-33K protein regulates both late gene expression patterns and viral DNA packaging. J Virol 87:6739-47
Rasmussen, John W; Tam, Jason W; Okan, Nihal A et al. (2012) Phenotypic, morphological, and functional heterogeneity of splenic immature myeloid cells in the host response to tularemia. Infect Immun 80:2371-81
Karen, Kasey A; Hearing, Patrick (2011) Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection. J Virol 85:4135-42
Nelson, Lindsay D; Chiantia, Salvatore; London, Erwin (2010) Perfringolysin O association with ordered lipid domains: implications for transmembrane protein raft affinity. Biophys J 99:3255-63

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