This application represents the second competitive renewal for our Training in HIV Pathogenesis T32 program that supports 6 predoctoral and 3 postdoctoral trainees per year. Our program is based at the University of Pennsylvania School of Medicine, the Children's Hospital of Philadelphia and the Wistar Institute, which occupy a single, contiguous campus in west Philadelphia. Together, these institutions have one of the largest HIV/AIDS research programs in the country, with a funding base of >$40 million as determined by the NIH Office of AIDS Research. This level of funding enabled our Center for AIDS Research (CFAR) to successfully apply for Tier-2 NIH funding (i.e. $2.25 million annually) in both 2004 and 2009. Amongst the many individuals who study HIV/AIDS on our campus, a highly select group of 15 trainers are associated with this program. Because we are intent on having a well-focused training program in which our trainees benefit from our facilities and trainers, we place special emphasis on collaborative science and a commitment to training students and postdoctoral fellows. The cohesive nature of our training program is demonstrated by the fact that all 15 trainers have published papers with other trainers, that 11 of the trainers have significant involvement (>50K per year in direct costs) with jointly funded NIH grants with other trainers (a total of 11 funded grants, not counting the CFAR grant), that there are many joint lab meetings, and that our trainers participate in programmatic activities and minority-recruitment efforts. To date, a total of 42 trainees from 17 different laboratories have been supported by this T32, including 22 Ph.D. students, 4 M.D./Ph.D. students, and 15 Ph.D. postdoctoral fellows. Of our trainees, 49% have been women and 20% under-represented minorities. Of the 9 postdoctoral fellows who have completed their training and left Penn, two are in academics, 6 are working scientists in industry, including two in Merck's HIV integrase program and one in Merck's vaccine program. One former postdoctoral trainee leads a TB vaccine program at the AERAS Foundation. Of the 26 predoctoral trainees, 11 are still in training at Penn, 10 are doing postdocs in virology and infectious diseases at institutions that include Harvard (2 trainees), Emory, NIH (2 trainees), and UCSF, 1 is interviewing for a postdoctoral position, 1 is a scientist in industry, 1 has entered an MPH program due to a strong interest in global health, 1 is in law school and 1 left the program for medical reasons.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Sharma, Opendra K
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University of Pennsylvania
Schools of Medicine
United States
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Chehoud, Christel; Dryga, Anatoly; Hwang, Young et al. (2016) Transfer of Viral Communities between Human Individuals during Fecal Microbiota Transplantation. MBio 7:e00322
Wu, Gary D; Compher, Charlene; Chen, Eric Z et al. (2016) Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production. Gut 65:63-72
Pinzone, Marilia Rita; Graf, Erin; Lynch, Lindsay et al. (2016) Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size. J Virol 90:10436-10445
Cadena, Cristhian; Stavrou, Spyridon; Manzoni, Tomaz et al. (2016) The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model. Retrovirology 13:45
Lauder, Abigail P; Roche, Aoife M; Sherrill-Mix, Scott et al. (2016) Comparison of placenta samples with contamination controls does not provide evidence for a distinct placenta microbiota. Microbiome 4:29
Langer, Simon M; Hopfensperger, Kristina; Iyer, Shilpa S et al. (2015) A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1. PLoS One 10:e0142118
McGuire, Jennifer L; Gill, Alexander J; Douglas, Steven D et al. (2015) Central and peripheral markers of neurodegeneration and monocyte activation in HIV-associated neurocognitive disorders. J Neurovirol 21:439-48
Ocwieja, Karen E; Sherrill-Mix, Scott; Liu, Changchun et al. (2015) A reverse transcription loop-mediated isothermal amplification assay optimized to detect multiple HIV subtypes. PLoS One 10:e0117852
Elliott, Sarah T C; Wetzel, Katherine S; Francella, Nicholas et al. (2015) Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV. J Virol 89:9252-61
Pardi, Norbert; Tuyishime, Steven; Muramatsu, Hiromi et al. (2015) Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes. J Control Release 217:345-51

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