This is a second revised application for competitive renewal for the UCSF Biology of Infectious Diseases Training Program to train physician-scientists for productive careers in fundamental scientific investigations of infectious diseases. Infectious diseases are the third most common cause of death in the United States, despite widespread availability of antibiotics, vaccines, and high standards of public health. Worldwide, infectious diseases are the leading cause of death. Emergence of new pathogens, re-emergence of old ones, increasing resistance to antimicrobials, and pressures of globalization have broken down barriers and contributed to the spread of infectious diseases. Strategies to contain and control the spread of infectious diseases increasingly will rely on strong epidemiologic and population-based approaches and advances in basic research resulting from applications of discoveries in the fields of genomics, microbial pathogenesis, and immunology. The UCSF Biology of Infectious Diseases Training Program, which is modeled according to Infectious Diseases Society of America guidelines and recommendations, features two training tracks, a Basic Investigator Track and a Clinical Investigator Track. These two tracks provide the structural framework for acquisition and translation of research tools, skills, and experiences and for cultivating the scientific creativity that are essential for a successful research-oriented career. The two-track structure also affords the opportunity for interdisciplinary exchange and interactions. The program benefits from a well-established didactic infrastructure and an interactive faculty who direct research programs offering a rich and diversified training environment of exceptional depth and quality. Training is focused on MD and MD-PhD applicants, but PhD post-doctoral candidates are also accepted. In existence for only five years, the program has had considerable success in transitioning trainees to independent sources of research funding and starting them on promising career trajectories. This revised application features an innovative plan to recruit underrepresented minority trainees into the program;viewed as the weakness of the previous version, we believe this plan represents a major strength of the revised proposal. Relevance: The proposed training program is highly relevant to public health, a major concern of which is the control of infectious diseases. We will be training the next generation of medical scientists who will have responsibility for public health and devising strategies to contain the threats posed by infectious agents, scientists who will conduct the studies needed to identify new agents, and those who will discover approaches and therapies to overcome them.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007641-10
Application #
8101963
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2000-08-01
Project End
2012-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
10
Fiscal Year
2011
Total Cost
$207,088
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Publicover, Jean; Gaggar, Anuj; Jespersen, Jillian M et al. (2018) An OX40/OX40L interaction directs successful immunity to hepatitis B virus. Sci Transl Med 10:
Patel, Rena C; Leddy, Anna M; Odoyo, Josephine et al. (2018) What motivates serodiscordant couples to prevent HIV transmission within their relationships: findings from a PrEP implementation study in Kenya. Cult Health Sex 20:625-639
Brown, Lillian; Langelier, Charles; Reid, Michael J A et al. (2017) Antimicrobial Resistance: A Call to Action! Clin Infect Dis 64:106-107
Langelier, Charles; Christenson, Stephanie A (2016) An Expression of Clinical Significance: Exploring the Human Genome to Understand the Variable Response to Rhinovirus. Am J Respir Crit Care Med 193:710-2
Solomon, Marc M; Schechter, Mauro; Liu, Albert Y et al. (2016) The Safety of Tenofovir-Emtricitabine for HIV Pre-Exposure Prophylaxis (PrEP) in Individuals With Active Hepatitis B. J Acquir Immune Defic Syndr 71:281-6
Sserwanga, Asadu; Sears, David; Kapella, Bryan K et al. (2015) Anti-malarial prescription practices among children admitted to six public hospitals in Uganda from 2011 to 2013. Malar J 14:331
Rosenberg, Oren S; Dovala, Dustin; Li, Xueming et al. (2015) Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell 161:501-512
Hagey, Jill M; Akama, Eliud; Ayieko, James et al. (2015) Barriers and facilitators adolescent females living with HIV face in accessing contraceptive services: a qualitative assessment of providers' perceptions in western Kenya. J Int AIDS Soc 18:20123
Woolston, Sophie; Cohen, Stephanie E; Fanfair, Robyn Neblett et al. (2015) A Cluster of Ocular Syphilis Cases - Seattle, Washington, and San Francisco, California, 2014-2015. MMWR Morb Mortal Wkly Rep 64:1150-1
Sears, David; Mpimbaza, Arthur; Kigozi, Ruth et al. (2015) Quality of inpatient pediatric case management for four leading causes of child mortality at six government-run Ugandan hospitals. PLoS One 10:e0127192

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