The proposed training program will continue to provide predoctoral trainees with a solid academic background in molecular pathogenesis, with a particular emphasis on host-pathogen interactions. Training will include relevant course work, regularly scheduled seminars and journal clubs, and rigorous laboratory training with the goal of preparing our students for careers in research in pathogenesis. Faculty recruitment efforts have resulted in the formation of a critical mass of established investigators in the broad area of microbial pathogenesis, and with it an integrated training program for predoctoral students in host-pathogen interactions has been established. In addition to their common research interests, many of the faculty have evidence of collaborative interactions. Faculty research interests encompass areas including regulation of virulence gene expression, host-pathogen interactions, molecular immunology and immune defense, molecular virology and parasitology. The program currently consists of 9 faculty, all of whom are current NIH grant holders and who, as a group, have had a substantial training history and enjoy national and international recognition in their respective fields. The training faculty represents a broad range of departmental affiliations, including the Departments of Microbiology and Medicine at Boston University School of Medicine, and the Department of Molecular and Cell Biology in the Boston University Goldman School of Dental Medicine. We expect the members of the training faculty to increase over the next several years as recruiting for the National Emerging Infections Disease Laboratory at Boston University School of Medicine begins. The training opportunities for predoctoral fellows in this program will also increase during this same period of time. The major goal of the program will be to 1) recruit and enroll students of this highest quality, including underrepresented minorities;2) provide these trainees with a multidisciplinary background in molecular pathogenesis coupled with intensive laboratory training in a particular research topic;3) to teach the trainees critical thinking skills and to ask relevant and feasible research questions;4) to instill these trainees with a sense of ethical behavior;5) to help develop effective written and oral communication skills among the trainees;and 6) to facilitate collaborative interactions among both students and faculty of the host-pathogen interaction training program.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Boston University
Schools of Medicine
United States
Zip Code
Bushkin, G Guy; Motari, Edwin; Carpentieri, Andrea et al. (2013) Evidence for a structural role for acid-fast lipids in oocyst walls of Cryptosporidium, Toxoplasma, and Eimeria. MBio 4:e00387-13
Tremaglio, Chadene Z; Noton, Sarah L; Deflube, Laure R et al. (2013) Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter. J Virol 87:3196-207
Hanley, Timothy M; Viglianti, Gregory A (2011) Nuclear receptor signaling inhibits HIV-1 replication in macrophages through multiple trans-repression mechanisms. J Virol 85:10834-50
Hanley, Timothy M; Blay Puryear, Wendy; Gummuluru, Suryaram et al. (2010) PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection. PLoS Pathog 6:e1000981
Dan, Jennifer M; Levitz, Stuart M (2006) Prospects for development of vaccines against fungal diseases. Drug Resist Updat 9:105-10
Lam, Jennifer S; Mansour, Michael K; Specht, Charles A et al. (2005) A model vaccine exploiting fungal mannosylation to increase antigen immunogenicity. J Immunol 175:7496-503