The Mechanism of Virus-Host Interactions Training Grant is a multidisciplinary training program designed to train and educate pre-doctoral and post-doctoral trainees in the broad discipline of Virology. This proposal requests continued support for the Virology training program. The faculty is derived from two research institutions, the Mount Sinai School of Medicine (MSSM) and the NYU School of Medicine (NYUSM). The research training emphasis is directed toward teaching pre-doctoral and post-doctoral trainees the theory and experimental approaches required for independent scientific investigations. Students learn the molecular mechanisms involved in virus replication and host responses to viral infections. Research training areas also include novel approaches for antiviral strategies and vaccine development against medically relevant viruses. Our trainees are highly successful in attaining independent research positions, peer-reviewed publications, and extramural research funding. Accordingly, six pre-doctoral and six post-doctoral positions are requested.
The specific aim of the program is to recruit and provide rigorous training to high caliber students and fellows. The continued support of this program will aid trainees in all phases of their development including understanding scientific method, interpretation of results, presentation of data and conclusions, research ethics, and career guidance. By combining the strengths of an outstanding group of virologists, we have created a world-class virology training program. This program is built upon existing collaborations, including research grants, and joint publications between faculty members at MSSM and NYUSM. Accordingly, our collaborative training effort has "added value" over single institution or individual based initiatives. The program faculty consists of twenty-eight outstanding virologists who use a diverse array of experimental strategies to study the molecular, cellular, biochemical and immunological interactions of viruses with their hosts.

Public Health Relevance

The Mechanism of Virus-Host Interactions Training Grant is vital to the development of the next generation of virologists. These trainees will be leaders in the field of Virology developing strategies to prevent and limit virus pathogenesis.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Icahn School of Medicine at Mount Sinai
Schools of Medicine
New York
United States
Zip Code
Morris, Lee; Kouya, Francine; Kwalar, Rene et al. (2014) Factors associated with inconsistent condom use in adolescents with negative or unknown HIV status in Northwest Cameroon. AIDS Care 26:1440-5
Krammer, Florian; Margine, Irina; Hai, Rong et al. (2014) H3 stalk-based chimeric hemagglutinin influenza virus constructs protect mice from H7N9 challenge. J Virol 88:2340-3
Krammer, Florian; Hai, Rong; Yondola, Mark et al. (2014) Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets. J Virol 88:3432-42
Hubbard-Lucey, Vanessa M; Shono, Yusuke; Maurer, Katie et al. (2014) Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells. Immunity 41:579-91
Kim, Ju Youn; Shiflett, Lora A; Linderman, Jessica A et al. (2014) Using homogeneous primary neuron cultures to study fundamental aspects of HSV-1 latency and reactivation. Methods Mol Biol 1144:167-79
Mercer, Frances; Khaitan, Alka; Kozhaya, Lina et al. (2014) Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors. J Immunol 193:1047-54
Alvarez, Raymond A; Hamlin, Rebecca E; Monroe, Anthony et al. (2014) HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells. J Virol 88:6031-46
Krammer, Florian; Albrecht, Randy A; Tan, Gene S et al. (2014) Divergent H7 immunogens offer protection from H7N9 virus challenge. J Virol 88:3976-85
McKinney, Caleb; Zavadil, Jiri; Bianco, Christopher et al. (2014) Global reprogramming of the cellular translational landscape facilitates cytomegalovirus replication. Cell Rep 6:9-17
Leyva-Grado, Victor H; Hai, Rong; Fernandes, Fiona et al. (2014) Modulation of an ectodomain motif in the influenza A virus neuraminidase alters tetherin sensitivity and results in virus attenuation in vivo. J Mol Biol 426:1308-21

Showing the most recent 10 out of 66 publications