Research in Virology requires more than a focused understanding of human pathogens. It requires comprehensive knowledge of viruses that infect hosts ranging from simple eukaryotes to complex multicellular organisms. A more comprehensive understanding ofthe breadth of Virology promises to provide the tools needed to control perplexing and devastating diseases in humans, as well as animals and plants. Substantive steps in knowledge acquisition require programs that prepare students to synthesize data from diverse systems, including model systems. The systems studied by University of Maryland Virology Program members include such important human pathogens as HIV, influenza, papillomavirus, poxvirus. West Nile, caliciviruses, as well as prions, viroids, fungal hypoviruses, and the model plant viruses Tobacco mosaic virus and Turnip crinkle virus. At the core of our training program are 14 well-funded investigators recognized as leaders in their fields from the Department of Cell Biology and Molecular Genetics, Maryland-Virginia Regional Vet Medicine, University of Maryland Biotechnology Institute Center for Biosystems Research, NIH, NCI, and USDA. Our faculty bring an extraordinarily broad range of expertise, from cellular and molecular biology to genomics and evolution, and from biochemistry to nanotechnology and vaccine development Trainees progress through innovative rotations, advanced courses in molecular and cellular biology, signal transduction, virology, and pathogenesis, journal clubs, attend monthly group meetings and a yearly retreat This training, along with state-of-the-art research projects, prepare trainees for careers centered on combating current and emerging viruses that threaten human health. This renewal application requests financial support for five graduate student traineeships. By combining this support with funds available through grants and intramural funds, over 20 pre-doctoral students will be trained in a five year period. The requested support will focus on attracting incoming students and students in their final years. We are committed to offering this exceptional training experience to highly-motivated students, with a special outreach to minorities, who will greatly enrich the potential for a global public health impact.

Public Health Relevance

Viruses infect nearly all life forms, are responsible for some human cancers, and are devastative disease agents that can cause world-wide pandemics. When properly harnessed, viruses can also be powerful research tools for dissecting cellular processes. This training proposal seeks continued support for training virologists prepared to meet research challenges common to all viruses- which include developing strategies to protect humans, animals, and niants from viral di.seases to imnrovfi the nualitv nf nennle's lives.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI051967-10
Application #
8484338
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
2002-08-01
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
10
Fiscal Year
2013
Total Cost
$168,047
Indirect Cost
$10,893
Name
University of Maryland College Park
Department
Anatomy/Cell Biology
Type
Schools of Earth Sciences/Natur
DUNS #
790934285
City
College Park
State
MD
Country
United States
Zip Code
20742
Collum, Tamara D; Padmanabhan, Meenu S; Hsieh, Yi-Cheng et al. (2016) Tobacco mosaic virus-directed reprogramming of auxin/indole acetic acid protein transcriptional responses enhances virus phloem loading. Proc Natl Acad Sci U S A 113:E2740-9
Kuhlmann, Micki M; Chattopadhyay, Maitreyi; Stupina, Vera A et al. (2016) An RNA Element That Facilitates Programmed Ribosomal Readthrough in Turnip Crinkle Virus Adopts Multiple Conformations. J Virol 90:8575-91
VanBlargan, Laura A; Davis, Kaitlin A; Dowd, Kimberly A et al. (2015) Context-Dependent Cleavage of the Capsid Protein by the West Nile Virus Protease Modulates the Efficiency of Virus Assembly. J Virol 89:8632-42
Chattopadhyay, Maitreyi; Stupina, Vera A; Gao, Feng et al. (2015) Requirement for Host RNA-Silencing Components and the Virus-Silencing Suppressor when Second-Site Mutations Compensate for Structural Defects in the 3' Untranslated Region. J Virol 89:11603-18
Chattopadhyay, Maitreyi; Kuhlmann, Micki M; Kumar, Kalyani et al. (2014) Position of the kissing-loop interaction associated with PTE-type 3'CITEs can affect enhancement of cap-independent translation. Virology 458-459:43-52
Belew, Ashton Trey; Meskauskas, Arturas; Musalgaonkar, Sharmishtha et al. (2014) Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway. Nature 512:265-9
Leshin, Jonathan A; Heselpoth, Ryan; Belew, Ashton Trey et al. (2011) High throughput structural analysis of yeast ribosomes using hSHAPE. RNA Biol 8:478-87
Belew, Ashton T; Advani, Vivek M; Dinman, Jonathan D (2011) Endogenous ribosomal frameshift signals operate as mRNA destabilizing elements through at least two molecular pathways in yeast. Nucleic Acids Res 39:2799-808
Kramer, Sabrina R; Goregaoker, Sameer P; Culver, James N (2011) Association of the Tobacco mosaic virus 126kDa replication protein with a GDI protein affects host susceptibility. Virology 414:110-8
Stupina, Vera A; Yuan, Xuefeng; Meskauskas, Arturas et al. (2011) Ribosome binding to a 5' translational enhancer is altered in the presence of the 3' untranslated region in cap-independent translation of turnip crinkle virus. J Virol 85:4638-53

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