The Duke University Graduate Program in Immunology proposes a continuation of its Basic Immunology Training Program. The main goal of the Training Program is to select talented predoctoral candidates and to prepare them, through formal coursework, seminars, and independent research, for outstanding and productive research careers in basic immunology. The training faculty consists of 22 immunologists who hold primary or secondary appointments in the Department of Immunology. This faculty provides trainees with opportunities for rigorous training in a range of areas of contemporary immunologic research, for example: mechanisms of lymphocyte development and function, including lymphoid lineage commitment, V(D)J recombination, lymphocyte signaling, effector cell development, homeostasis, and tolerance;mechanisms of innate immunity and inflammation, including macrophage, dendritic cell, mast cell and complement function;mechanisms of host defense against bacterial and viral pathogens;the development of autoimmune and immunodeficiency diseases;and anti-tumor immunity. Funds are sought to support the training of four students per year. A selections committee will choose for support the most outstanding predoctoral trainees from among students accepted into the Graduate Program in Immunology. These students will receive support during their first and second years, until their admission to doctoral candidacy and the initiation of dissertation research. A carefully crafted core curriculum will provide trainees with superb grounding in basic immunology, cell biology, molecular biology and genetics. The Basic Immunology Training Program will teach the next generation of U.S. researchers the critical skills they will need to perform outstanding basic immunologic research. Future discoveries by these researchers will be absolutely essential for our continued progress in the fights against infectious diseases, cancer, and autoimmune and immunodeficiency diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI052077-08
Application #
7784445
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2002-07-01
Project End
2013-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
8
Fiscal Year
2010
Total Cost
$173,964
Indirect Cost
Name
Duke University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Bao, Katherine; Carr, Tiffany; Wu, Jianxuan et al. (2016) BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity. J Immunol 197:4371-4381
O'Brien, T F; Bao, K; Dell'Aringa, M et al. (2016) Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation. Mucosal Immunol 9:597-609
Lykken, Jacquelyn M; Horikawa, Mayuka; Minard-Colin, Veronique et al. (2016) Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms. Blood 127:1886-95
Lykken, Erik Allen; Li, Qi-Jing (2016) The MicroRNA miR-191 Supports T Cell Survival Following Common ? Chain Signaling. J Biol Chem 291:23532-23544
Xu, Xin; Zhang, Yun; Jasper, Jeff et al. (2016) MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer. Oncotarget 7:20381-94
Long, Haixia; Xiang, Tong; Luo, Jing et al. (2016) The tumor microenvironment disarms CD8+ T lymphocyte function via a miR-26a-EZH2 axis. Oncoimmunology 5:e1245267
Zhang, Baojun; Liu, Si-Qi; Li, Chaoran et al. (2016) MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium. Immunity 44:568-581
Chen, Liang; Foreman, Daniel P; Sant'Angelo, Derek B et al. (2016) Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53. J Immunol 196:2572-82
Yu, Yen-Rei A; O'Koren, Emily G; Hotten, Danielle F et al. (2016) A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues. PLoS One 11:e0150606
Majumder, Kinjal; Koues, Olivia I; Chan, Elizabeth A W et al. (2015) Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. J Exp Med 212:107-20

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