The Duke University Graduate Program in Immunology proposes a continuation of its Basic Immunology Training Program. The main goal of the Training Program is to select talented predoctoral candidates and to prepare them, through formal coursework, seminars, and independent research, for outstanding and productive research careers in basic immunology. The training faculty consists of 22 immunologists who hold primary or secondary appointments in the Department of Immunology. This faculty provides trainees with opportunities for rigorous training in a range of areas of contemporary immunologic research, for example: mechanisms of lymphocyte development and function, including lymphoid lineage commitment, V(D)J recombination, lymphocyte signaling, effector cell development, homeostasis, and tolerance;mechanisms of innate immunity and inflammation, including macrophage, dendritic cell, mast cell and complement function;mechanisms of host defense against bacterial and viral pathogens;the development of autoimmune and immunodeficiency diseases;and anti-tumor immunity. Funds are sought to support the training of four students per year. A selections committee will choose for support the most outstanding predoctoral trainees from among students accepted into the Graduate Program in Immunology. These students will receive support during their first and second years, until their admission to doctoral candidacy and the initiation of dissertation research. A carefully crafted core curriculum will provide trainees with superb grounding in basic immunology, cell biology, molecular biology and genetics. The Basic Immunology Training Program will teach the next generation of U.S. researchers the critical skills they will need to perform outstanding basic immunologic research. Future discoveries by these researchers will be absolutely essential for our continued progress in the fights against infectious diseases, cancer, and autoimmune and immunodeficiency diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI052077-10
Application #
8269019
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2002-07-01
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2012
Total Cost
$175,391
Indirect Cost
$8,554
Name
Duke University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
O'Brien, T F; Bao, K; Dell'Aringa, M et al. (2016) Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation. Mucosal Immunol 9:597-609
Ci, Xinxin; Kuraoka, Masayuki; Wang, Hongxia et al. (2015) TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. PLoS One 10:e0127527
Reynolds, Alexander E; Kuraoka, Masayuki; Kelsoe, Garnett (2015) Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow. J Immunol 194:231-42
Majumder, Kinjal; Koues, Olivia I; Chan, Elizabeth A W et al. (2015) Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. J Exp Med 212:107-20
Cubas, Rafael; van Grevenynghe, Julien; Wills, Saintedym et al. (2015) Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection. J Immunol 195:5625-36
Carico, Zachary; Krangel, Michael S (2015) Chromatin Dynamics and the Development of the TCRα and TCRδ Repertoires. Adv Immunol 128:307-61
Lykken, Jacquelyn M; Tedder, Thomas F (2015) The Tumor Microenvironment Regulates CD19 and CD20 Immunotherapy for Lymphoma. Cancer J 21:351-6
Mitchell, Duane A; Batich, Kristen A; Gunn, Michael D et al. (2015) Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients. Nature 519:366-9
Lykken, Jacquelyn M; Candando, Kathleen M; Tedder, Thomas F (2015) Regulatory B10 cell development and function. Int Immunol 27:471-7
Bao, Katherine; Reinhardt, R Lee (2015) The differential expression of IL-4 and IL-13 and its impact on type-2 immunity. Cytokine 75:25-37

Showing the most recent 10 out of 33 publications