Although medical advances prolong the lives of many patients with otherwise debilitating or uniformly fatal diseases, such as cancer, AIDS, and organ or stem cell transplants, these medical interventions often compromise host defenses and immunity. Consequently, the incidence of opportunistic fungal infections continues to increase. The development of new antifungal drugs has improved the prognosis for many patients, but they have also fostered the emergence of new and more resistant pathogenic fungi. Thus, it is essential to recruit and train young scientists to develop rigorous independent careers focused on mycological research. The same mandate applies to research on fungal plant pathogens, which continue to reduce the global food supply. Other, non-pathogenic fungi serve as models for eukaryotic systems, and they have fostered profound discoveries and progress in the biomedical sciences and biotechnology. Indeed, progress in genomics and bioinformatics have enhanced the impact of fungal biology and increased the demand for scientists who are capable of applying these methods to model fungi. This application proposes a continuation of the multidisciplinary, tri-institutional Molecular Mycology and Pathogenesis Training Program (MMPTP), which was awarded five years ago. The MMPTP recruits, supports, and trains promising postdoctoral scientists and physicians to develop productive research careers in molecular mycology and pathogenesis. These trainees will become the future experts and leaders in broad areas of fungal research in academia, industry, and government. Candidates for training include recent doctoral graduates in biomedical sciences, physicians who have completed residency training, and scientists from other disciplines who want to apply their expertise to fungi. The participating faculty constitute perhaps the greatest concentration of researchers who study fungi. They share resources, interact regularly, and collaborate frequently. The MMPTP has been highly successful. Over the past five years, we have supported 14 trainees. All nine trainees who completed the program are employed as productive scientists in the USA. One is President of a microbiological diagnostics company, one is a governmental scientist, two are continuing postdoctoral research, and the other five are tenure-tract Assistant Professors at research universities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI052080-08
Application #
8106088
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2003-09-01
Project End
2014-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
8
Fiscal Year
2011
Total Cost
$317,174
Indirect Cost
Name
Duke University
Department
Genetics
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Shwab, Elliot K; Juvvadi, Praveen R; Waitt, Greg et al. (2017) Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms. FEBS Lett 591:3730-3744
Thaden, Joshua T; Li, Yanhong; Ruffin, Felicia et al. (2017) Increased Costs Associated with Bloodstream Infections Caused by Multidrug-Resistant Gram-Negative Bacteria Are Due Primarily to Patients with Hospital-Acquired Infections. Antimicrob Agents Chemother 61:
Thaden, Joshua T; Park, Lawrence P; Maskarinec, Stacey A et al. (2017) Results from a 13-Year Prospective Cohort Study Show Increased Mortality Associated with Bloodstream Infections Caused by Pseudomonas aeruginosa Compared to Other Bacteria. Antimicrob Agents Chemother 61:
Shwab, E Keats; Juvvadi, Praveen R; Waitt, Greg et al. (2017) A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus. MBio 8:
Miao, Yi; Tenor, Jennifer L; Toffaletti, Dena L et al. (2017) Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design. MBio 8:
Okagaki, Laura H; Sailsbery, Joshua K; Eyre, Alexander W et al. (2016) Comparative genome analysis and genome evolution of members of the magnaporthaceae family of fungi. BMC Genomics 17:135
Maskarinec, Stacey A; Fowler Jr, Vance G (2016) Persistent Rash in a Patient Receiving Total Parenteral Nutrition. JAMA 315:2223-4
Maskarinec, Stacey A; Johnson, Melissa D; Perfect, John R (2016) Genetic Susceptibility to Fungal Infections: What is in the Genes? Curr Clin Microbiol Rep 3:81-91
Miao, Yi; Tenor, Jennifer L; Toffaletti, Dena L et al. (2016) Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis. Proc Natl Acad Sci U S A 113:7148-53
Chen, Li; Li, Yan; Yue, Qun et al. (2016) Engineering of New Pneumocandin Side-Chain Analogues from Glarea lozoyensis by Mutasynthesis and Evaluation of Their Antifungal Activity. ACS Chem Biol 11:2724-2733

Showing the most recent 10 out of 69 publications