Although medical advances prolong the lives of many patients with otherwise debilitating or uniformly fatal diseases, such as cancer, AIDS, and organ or stem cell transplants, these medical interventions often compromise host defenses and immunity. Consequently, the incidence of opportunistic fungal infections continues to increase. The development of new antifungal drugs has improved the prognosis for many patients, but they have also fostered the emergence of new and more resistant pathogenic fungi. Thus, it is essential to recruit and train young scientists to develop rigorous independent careers focused on mycological research. The same mandate applies to research on fungal plant pathogens, which continue to reduce the global food supply. Other, non-pathogenic fungi serve as models for eukaryotic systems, and they have fostered profound discoveries and progress in the biomedical sciences and biotechnology. Indeed, progress in genomics and bioinformatics have enhanced the impact of fungal biology and increased the demand for scientists who are capable of applying these methods to model fungi. This application proposes a continuation of the multidisciplinary, tri-institutional Molecular Mycology and Pathogenesis Training Program (MMPTP), which was awarded five years ago. The MMPTP recruits, supports, and trains promising postdoctoral scientists and physicians to develop productive research careers in molecular mycology and pathogenesis. These trainees will become the future experts and leaders in broad areas of fungal research in academia, industry, and government. Candidates for training include recent doctoral graduates in biomedical sciences, physicians who have completed residency training, and scientists from other disciplines who want to apply their expertise to fungi. The participating faculty constitute perhaps the greatest concentration of researchers who study fungi. They share resources, interact regularly, and collaborate frequently. The MMPTP has been highly successful. Over the past five years, we have supported 14 trainees. All nine trainees who completed the program are employed as productive scientists in the USA. One is President of a microbiological diagnostics company, one is a governmental scientist, two are continuing postdoctoral research, and the other five are tenure-tract Assistant Professors at research universities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI052080-10
Application #
8473150
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
2003-09-01
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
10
Fiscal Year
2013
Total Cost
$288,654
Indirect Cost
$26,053
Name
Duke University
Department
Genetics
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Gónzalez, Dolores; Rodriguez-Carres, Marianela; Boekhout, Teun et al. (2016) Phylogenetic relationships of Rhizoctonia fungi within the Cantharellales. Fungal Biol 120:603-19
Maskarinec, Stacey A; Fowler Jr, Vance G (2016) Persistent Rash in a Patient Receiving Total Parenteral Nutrition. JAMA 315:2223-4
Okagaki, Laura H; Sailsbery, Joshua K; Eyre, Alexander W et al. (2016) Comparative genome analysis and genome evolution of members of the magnaporthaceae family of fungi. BMC Genomics 17:135
Maskarinec, Stacey A; Johnson, Melissa D; Perfect, John R (2016) Genetic Susceptibility to Fungal Infections: What is in the Genes? Curr Clin Microbiol Rep 3:81-91
Miao, Yi; Tenor, Jennifer L; Toffaletti, Dena L et al. (2016) Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis. Proc Natl Acad Sci U S A 113:7148-53
Franck, William L; Gokce, Emine; Randall, Shan M et al. (2015) Phosphoproteome Analysis Links Protein Phosphorylation to Cellular Remodeling and Metabolic Adaptation during Magnaporthe oryzae Appressorium Development. J Proteome Res 14:2408-24
Strope, Pooja K; Kozmin, Stanislav G; Skelly, Daniel A et al. (2015) 2μ plasmid in Saccharomyces species and in Saccharomyces cerevisiae. FEMS Yeast Res 15:
Oono, Ryoko; Lefèvre, Emilie; Simha, Anita et al. (2015) A comparison of the community diversity of foliar fungal endophytes between seedling and adult loblolly pines (Pinus taeda). Fungal Biol 119:917-28
Strope, Pooja K; Skelly, Daniel A; Kozmin, Stanislav G et al. (2015) The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen. Genome Res 25:762-74
Janbon, Guilhem; Ormerod, Kate L; Paulet, Damien et al. (2014) Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. PLoS Genet 10:e1004261

Showing the most recent 10 out of 61 publications