This is a competitive renewal application for a NIH T32 institutional training grant for continuation of a new training program at Baylor College of Medicine focused on the training of physicians as investigators in the discipline of immunology. Initial funding has supported 6 trainees, of which 100% (3/3) of graduating trainees have taken tenure track academic positions, 83% are women, and 50% (3) of trainees are URM. Trainees are recruited and selected from a large pool of outstanding applicants to Baylor's ACGME/RRC approved training programs in allergy and immunology and in rheumatology. Continuation of four postdoctoral trainee positions annually is requested. Trainees are competitively selected for appointed to the T32 training program each year for two to three years of rigorous scientific training. Eighteen tenure track faculty have been carefully selected to serve as mentors, based on their excellence in research and teaching. Trainees enroll in graduate school courses and Baylor's NIH K30 supported physician scientist curriculum in clinical investigation to acquire a sound fund of knowledge in basic science and immunology, the principles of conducting clinical research, and the ethical conduct of research. Trainees will be comprehensively mentored in hypothesis driven research, preparation and publication of manuscripts, presentations at national meetings, preparation of grant proposals, skills for teaching and mentoring, and academic career development. The mentors are selected from over 40 faculty within Baylor's multidisciplinary Biology of Inflammation Center, NIH/NIAID Texas Medical Center Asthma and Allergic Diseases Cooperative Research Center, and HHMI Translational Biology and Molecular Medicine graduate program,, which provides a highly interactive critical mass of investigators with diverse trainees comprised of graduate students, medical students, PhD postdocs, MD postdocs, and MD/PhD postdocs. Mentors provide training opportunities in cytokine structure and function, chemokine biology, adhesion molecules, signal transduction and termination of signaling, gene activation, molecular genetics, tissue remodeling, cellular immunology and immunoregulation, murine models of inflammation, infection and immunity, the pathobiology of immune-mediated diseases, design of valid tools for epidemiology, and clinical trial outcome analysis. The goal of this training program is to continue to develop immunology physician-scientists who will serve as future academic leaders.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
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Baylor College of Medicine
Internal Medicine/Medicine
Schools of Medicine
United States
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Huq, Redwan; Samuel, Errol L G; Sikkema, William K A et al. (2016) Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation. Sci Rep 6:33808
Bian, Fang; Wang, Changjun; Tukler-Henriksson, Johanna et al. (2016) MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. J Cell Physiol 231:2506-16
de Paiva, Cintia S; Jones, Dan B; Stern, Michael E et al. (2016) Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome. Sci Rep 6:23561
Pethő, Zoltán; Tanner, Mark R; Tajhya, Rajeev B et al. (2016) Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes. Arthritis Res Ther 18:103
Fortune, Ryan D; Grill, Raymond J; Beeton, Christine et al. (2016) Changes in Gene Expression and Metabolism in the Testes of the Rat following Spinal Cord Injury. J Neurotrauma :
Tajhya, Rajeev B; Hu, Xueyou; Tanner, Mark R et al. (2016) Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. Cell Death Dis 7:e2426
Pedroza, Mesias; Le, Thuy T; Lewis, Katherine et al. (2016) STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation. FASEB J 30:129-40
Bian, Fang; Pelegrino, Flavia S A; Henriksson, Johanna Tukler et al. (2016) Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye. Ocul Surf 14:242-54
Bian, Fang; Shin, Crystal S; Wang, Changjun et al. (2016) Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye. Invest Ophthalmol Vis Sci 57:3222-30
Laragione, Teresina; Cheng, Kai F; Tanner, Mark R et al. (2015) The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion. Clin Immunol 158:183-92

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