Despite advances in public health and medical therapeutics, infectious diseases continue to represent the leading cause of morbidity and mortality worldwide which extracts a considerable financial and societal toll even in developed countries due to factors such as emerging pathogens, AIDS or other immunocompromising conditions, and antimicrobial resistance. Between 1980 and 1992, the U.S. death rate from infectious diseases, excluding HIV/AIDS, rose by 22%. Infectious diseases are presently the third leading cause of death in the U.S. and the leading cause worldwide. Familiar bacterial pathogens such as Salmonella and Mycobacterium tuberculosis continue to contribute to the deaths of millions of people each year, while other pathogens such as Escherichia coli 0157:H7 and community-acquired Methicillin-Resistant Staphylococcus aureus have emerged as new threats. The recent specter of bioterrorism has only served to heighten concern that a better understanding of the pathogenesis of infection is needed. The training of new scientists who can elucidate basic mechanisms of microbial pathogenesis will be critical for the formulation of improved strategies to prevent, diagnose and treat infectious diseases. This application for renewed support of a Training Program in Bacterial Pathogenesis centers around an established and highly interactive interdisciplinary research community and the University of Washington. The goal of the program is to provide comprehensive interdisciplinary training and mentorship for pre- and post-doctoral trainees who seek to understand fundamental cellular and molecular mechanisms of the interactions between bacterial pathogens and their hosts. This training will ultimately allow them to obtain new scientific insights as independent investigators that can lead to novel approaches for the prevention and management of infectious diseases.

Public Health Relevance

This is a program to provide research training to scientists who study bacterial infections such as typhoid and tuberculosis. An increased understanding of these conditions will be essential for the development of improved strategies for the prevention and treatment of human infections.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Peters, Kent
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University of Washington
Schools of Medicine
United States
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Conrad, William H; Osman, Morwan M; Shanahan, Jonathan K et al. (2017) Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions. Proc Natl Acad Sci U S A 114:1371-1376
Gall, Alevtina; Gaudet, Ryan G; Gray-Owen, Scott D et al. (2017) TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection. MBio 8:
Huynh, TuAnh Ngoc; Choi, Philip H; Sureka, Kamakshi et al. (2016) Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC. Mol Microbiol 102:233-243
Eshraghi, Aria; Kim, Jungyun; Walls, Alexandra C et al. (2016) Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth. Cell Host Microbe 20:573-583
Huynh, TuAnh Ngoc; Woodward, Joshua J (2016) Too much of a good thing: regulated depletion of c-di-AMP in the bacterial cytoplasm. Curr Opin Microbiol 30:22-29
Kinkel, Traci L; Ramos-Montañez, Smirla; Pando, Jasmine M et al. (2016) An essential role for bacterial nitric oxide synthase in Staphylococcus aureus electron transfer and colonization. Nat Microbiol 2:16224
Gall, Alevtina; Fero, Jutta; McCoy, Connor et al. (2015) Bacterial Composition of the Human Upper Gastrointestinal Tract Microbiome Is Dynamic and Associated with Genomic Instability in a Barrett's Esophagus Cohort. PLoS One 10:e0129055
Pagán, Antonio J; Yang, Chao-Tsung; Cameron, James et al. (2015) Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment. Cell Host Microbe 18:15-26
Fang, Ferric C; Weiss, Günter (2014) Iron ERRs with Salmonella. Cell Host Microbe 15:515-6
Christensen, Quin H; Brecht, Ryan M; Dudekula, Dastagiri et al. (2014) Evolution of acyl-substrate recognition by a family of acyl-homoserine lactone synthases. PLoS One 9:e112464

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