A community of investigators seeks new support for a predoctoral training program in microbial pathogenesis and host responses at the University of Wisconsin. This topic area has long been important due to the prevalence and consequences of infectious diseases, and now its significance is re-emphasized by dangers of bioterrorism and the ever-widening demonstration of previously unrecognized infectious or immunological etiologies for human maladies. The Microbiology Doctoral Training Program (MDTP) is a highly ranked graduate program that enrolls -20-25 students each year as a source of trainees. """"""""Microbial pathogenesis"""""""" is the largest of the MDTP subdisciplinary areas self-identified for affiliation by the ~ 80 MDTP faculty. The separate interlab Microbial Pathogenesis and Host Responses Group (MPHRG) holds regular meetings, hosts invited outside speakers, and has a website and listserver. The Dept. of Medical Microbiology & Immunology is a central core of both MDTP and MPHRG, and offers relevant didactic, journal club, and seminar courses. Instruction is provided in prokaryotic and eukaryotic microbial pathogenesis, virology and viral pathogenesis, and immunology and infectious diseases, as well as in responsible conduct of research. There are a student research seminar series, a journal club course, and regularly scheduled guest speakers. Our 20 trainers and 2 affiliates span 10 departments in 3 colleges. All trainers are productive scientists with proven NIH R01 or equivalent funding track records and extensive graduate training experience;most are tenured (11 full, 5 associate professors). Promising junior faculty may hold affiliate status, primed for trainer status upon development of funding and training experience. These faculty are interactive scientific colleagues dedicated to recruitment of outstanding graduate students including focused efforts for minority candidates. They are committed to predoctoral mentoring and didactic and research training. Trainers cooperatively participate in course teaching and provide students with lab homes for research rotations and thesis work. Each graduate student is mentored by a thesis committee consisting of the thesis advisor and 4 other faculty members, and all program trainees are co-mentored by virtue of joint trainer service on thesis committees. The program and its trainers are held in high regard in the scientific community, and the success of the training program is demonstrated by the typical progress of its graduates into competitive postdoctoral trainincj positions and subsequently into academic, industry, or 9overnment research careers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI055397-10
Application #
8301584
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2003-08-01
Project End
2013-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
10
Fiscal Year
2012
Total Cost
$200,350
Indirect Cost
$13,709
Name
University of Wisconsin Madison
Department
Pediatrics
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Chen, Grischa Y; Pensinger, Daniel A; Sauer, John-Demian (2017) Listeria monocytogenes cytosolic metabolism promotes replication, survival, and evasion of innate immunity. Cell Microbiol 19:
Chen, Grischa Y; McDougal, Courtney E; D'Antonio, Marc A et al. (2017) A Genetic Screen Reveals that Synthesis of 1,4-Dihydroxy-2-Naphthoate (DHNA), but Not Full-Length Menaquinone, Is Required for Listeria monocytogenes Cytosolic Survival. MBio 8:
Neumann, Anthony P; McCormick, Caroline A; Suen, Garret (2017) Fibrobacter communities in the gastrointestinal tracts of diverse hindgut-fermenting herbivores are distinct from those of the rumen. Environ Microbiol 19:3768-3783
Caine, Elizabeth A; Osorio, Jorge E (2017) In Vivo Imaging with Bioluminescent Enterovirus 71 Allows for Real-Time Visualization of Tissue Tropism and Viral Spread. J Virol 91:
Wiesner, Darin L; Klein, Bruce S (2017) Lung epithelium: barrier immunity to inhaled fungi and driver of fungal-associated allergic asthma. Curr Opin Microbiol 40:8-13
Soukup, Alexandra A; Fischer, Gregory J; Luo, Jerry et al. (2017) The Aspergillus nidulans Pbp1 homolog is required for normal sexual development and secondary metabolism. Fungal Genet Biol 100:13-21
Lenz, Jonathan D; Hackett, Kathleen T; Dillard, Joseph P (2017) A Single Dual-Function Enzyme Controls the Production of Inflammatory NOD Agonist Peptidoglycan Fragments by Neisseria gonorrhoeae. MBio 8:
Kreznar, Julia H; Keller, Mark P; Traeger, Lindsay L et al. (2017) Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes. Cell Rep 18:1739-1750
Wiesner, Darin L; Klein, Bruce S (2017) The balance between immunity and inflammation. Science 357:973-974
Felley, Laura E; Sharma, Akshat; Theisen, Erin et al. (2016) Human Invariant NKT Cells Induce IL-1? Secretion by Peripheral Blood Monocytes via a P2X7-Independent Pathway. J Immunol 197:2455-64

Showing the most recent 10 out of 91 publications