Our community of investigators seeks renewed support for a pre- and post-doctoral training program that addresses the role of microbes in health and disease at the University of Wisconsin-Madison. Microbiology is fundamentally important to human health due to the prevalence and consequences of infectious diseases. Its significance has been elevated by bioterrorism and discoveries of the unforeseen roles for microbes in certain human maladies and in promoting normal human physiology and health. The proposed Microbes in Health and Disease (MHD) training program represents the natural and synergistic synthesis of the broad disciplines microbial pathogenesis, beneficial microbiology, and host responses. MHD will have its physical and intellectual home in a state-of-the-art new Microbial Sciences Building where basic and clinical scientists interact and collaborate, providing a strong sense of place, cohesion and identity to the Training Program. Our pre-doctoral trainees are drawn chiefly from the Microbiology Doctoral Training Program (MDTP), a highly ranked graduate program. Our post-doctoral fellows are drawn chiefly from a strong pool of PhD and Infectious Disease MD fellows, the latter from a program with a long history of placing fellows into academic medicine. MHD trainees and faculty trainers hold program-wide bi-weekly meetings together, host invited speakers, and have a website and list serve. Medical Microbiology and Immunology, Bacteriology, Internal Medicine, and Pediatrics are core departments of MHD and MDTP activities, and offer required didactic, journal club and seminar courses to our trainees. Instruction is provided in host-microbe interactions, microbial pathogenesis, immunology, infectious disease, translational medicine, and the responsible conduct of research. Our 31 faculty trainers span 9 departments in 4 colleges and actively collaborate with each other in both research and teaching. All faculty trainers are productive scientists with proven NIH or equivalent funding records and strong records of graduate training. Most are tenured (20 full, 7 associate professors) and 4 promising junior faculty trainers will be mentored by senior training faculty. The training program faculty are dedicated to recruiting outstanding students and fellows, including focused efforts for minority candidates, and are committed to pre- and post-doctoral mentoring and didactic and research training. To support this commitment, and the NIH- stated need to train scientists in the area of microbes in health and disease, support is requested for 8 trainees annually: 5 predoctoral trainees, and 3 postdoctoral trainees, including two MD and one PhD fellows. Each trainee is mentored by a committee consisting of a thesis advisor or mentor and 4 other faculty, and all trainees are also co-mentored by virtue of joint trainer service on these committees. The program and its trainers are highly regarded in the scientific community, and fill a unique niche on campus and a critical national need. The success of the program in the past cycle is evidenced by 86 collective publications among the 15 trainees, and their progress into competitive postdoctoral positions or academic, industry or government research careers.

Public Health Relevance

We propose the continuation of our pre-doctoral and post-doctoral training program on research in Microbiology and Infectious Diseases. The program, which is entitled Microbes in Health and Disease, focuses on training basic and clinical scientists in understanding the beneficial and harmful roles of microbes related to human health. The program has its intellectual and physical hub in an extraordinary new building devoted to microbial sciences that is located in the heart of the University of Wisconsin-Madison campus, where Microbiology training programs have been ranked among the best nationally. The training program offers a natural and synergistic synthesis of the contemporary fields microbial pathogenesis and host response together with symbiosis (beneficial microbiology). A cadre of outstanding faculty trainers across microbiology will offer trainees exposure to cutting edge topics and research in classrooms and laboratories, ensuring excellent doctoral or postdoctoral research training, and preparing them for successful and rewarding careers as leaders in Science.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI055397-11A1
Application #
8742918
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Program Officer
Robbins, Christiane M
Project Start
2003-08-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Madison
State
WI
Country
United States
Zip Code
53715
Sterkel, Alana K; Lorenzini, Jenna L; Fites, J Scott et al. (2016) Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity. Cell Host Microbe 19:361-74
Schwartzman, Julia A; Ruby, Edward G (2016) Stress as a Normal Cue in the Symbiotic Environment. Trends Microbiol 24:414-24
Soukup, Alexandra A; Keller, Nancy P; Wiemann, Philipp (2016) Enhancing Nonribosomal Peptide Biosynthesis in Filamentous Fungi. Methods Mol Biol 1401:149-60
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Aliota, Matthew T; Caine, Elizabeth A; Walker, Emma C et al. (2016) Characterization of Lethal Zika Virus Infection in AG129 Mice. PLoS Negl Trop Dis 10:e0004682
Aschtgen, Marie-Stephanie; Lynch, Jonathan B; Koch, Eric et al. (2016) Rotation of Vibrio fischeri Flagella Produces Outer Membrane Vesicles That Induce Host Development. J Bacteriol 198:2156-65
Schwartzman, Julia A; Ruby, Edward G (2016) A conserved chemical dialog of mutualism: lessons from squid and vibrio. Microbes Infect 18:1-10

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